Lescar, Julien - Nanyang Technological University

个人简介

Education Ph.D Biological Crystallography (1993) from University Paris XI - Institut Pasteur Paris Professional Experience I have been trained in biochemistry and macromolecular crystallography at the Institut Pasteur in Paris, FRANCE during my Ph.D. and also during a post-doctoral stay (1995-1996). After a training period in Washington University in St Louis (MO, USA) (1994), I joined the ESRF-EMBL Joint-Structural Biology group in Grenoble, FRANCE, where I spent the last five years (1997-2001) as a staff scientist.

研究领域

My main Research Interests concern the determination of the three-dimensional structures of proteins and how these relate to their functions. To this end, I use a combination of biochemical and X-ray crystallographic methods. My research is focused on proteins with immunological interest like viral proteins, antibodies and their complexes.

近期论文

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Fan H, Ooi A, Tan YW, Wang S, Fang S, Liu DX & Lescar J (2005) Crystal Structure of the N-terminal Domain from the Nucleocapsid Protein of Coronavirus Infectious Bronchitis Virus and multimerization properties. Structure 13, 1859-1868 Ting X, Ooi A, Lee HC, Wilmouth R, Liu D.X, Lescar J. (2005) Structure of the SARS coronavirus Main proteinase as an active C2 crystallographic dimer. Acta Cryst F61, 964-966 Shi M, Sundramurthy K, Liu B, Tan SM, Law A & Lescar J (2005) The crystal structure of the PSI/Hybrid domain/I-EGF1 segment from the Human Integrin β2 subunit at 1.8 Å resolution. > J. Biol. Chem. 280, 30586-30593 Xu T., Sampath A, Chao A, Wen D, Nanao M, Chene P, Vasudevan S G & Lescar J (2005) Structure of the dengue virus helicase/NTPase catalytic domain at 2.4 Å resolution. J. Virol. 79, 10278-10288 Chu J., Rajamanonmani R., Li J, Bhuvanakantham R., Lescar J, Ng M-L (2005) Inhibition of West Nile virus entry by using a recombinant Domain III from the envelope glycoprotein. J. Gen. Virol. 86, 405-412 Bressanelli S, Stiasny K., Allison S., Stura E.A., Duquerroy S., Lescar J., Heinz F.X., Rey F.A. (2004) Structure of a flavivirus envelope glycoprotein in its low-pH-induced membrane fusion conformation. EMBO J.23, 728-738 Lescar J ., Loris R., Mitchell E., Gautier C., Chazalet V., Cox V., Wyns L., Pérez S., Breton C., Imberty A. (2002) Isolectins I-A and I-B of Griffonia (Bandeiraea) simplicifolia: crystal structure of metal-free GSI-B4 and molecular basis for metal binding and monosaccharide specificity J. Biol. Chem.277, 6608-6614 Delarue M., Boulé J-B, Lescar J., Expert-Bezançon N., Jourdan N., Sukumar N., Rougeon F., Papanicolaou C. (2002) Crystal structure of a template independent DNA polymerase: murine Terminal deoxynucleotidyl Transferase EMBO J.21, 427-439 Rezacova P., Lescar J., Brynda J., Fabry M., Horejsi M., Sedlacek J., Bentley G.A. (2001) Structural basis of HIV-1 and HIV-2 Protease Inhibition by a monoclonal antibody Structure9, 887-895 Lescar J ., Roussel A., Wien M.W., Navaza J., Fuller S.D., Wengler G., Wengler G., Rey F.A. (2001) The fusion glycoprotein shell of Semliki Forest Virus: an icosahedral assembly primed for fusogenic activation at endosomal pH. Cell 105, 137-148