Zhao, Yanli - Nanyang Technological University - Division of Chemistry and Biological Chemistry

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W. Wang, P. H. Tham, C. Ding, P. Huang, T. Li, J. Luo, H. Xiang, X. Zeng, H. Chen, Y. L. Zhao, Transethosome-based topical administration systems with enhanced penetration and dual actions for treating EGFR-overexpressed cutaneous squamous cell carcinoma. Adv. Funct. Mater. 2024, accepted. Z. Ma, P. Zeng, T. Zhai, Y. L. Zhao, H. Liang, In situ mitochondrial biomineralization for drug-free cancer therapy. Adv. Mater. 2024, accepted. J.-R. Wang, K. Song, T.-X. Luan, K. Cheng, Q. Wang, Y. Wang, W. W. Yu, P.-Z. Li, Y. L. Zhao, Robust links in photoactive covalent organic frameworks enable effective photocatalytic reactions under harsh conditions. Nat. Commun. 2024, accepted. X. Wu, Y. Li, M. Wen, Y. Xie, K. Zeng, Y.-N. Liu, W. Chen, Y. L. Zhao, Nanocatalysts for modulating antitumor immunity: fabrications, mechanisms and applications. Chem. Soc. Rev. 2024, accepted. Y. Liu, R. Niu, H. Zhao, Y. Wang, S. Song, H. Zhang, Y. L. Zhao, Single-site nanozymes with a highly conjugated coordination structure for antitumor immunotherapy via cuproptosis and cascade-enhanced T lymphocyte activity. J. Am. Chem. Soc. 2024, accepted. Y. Liu, H. Zhao, Y. L. Zhao, Designing efficient single metal atom biocatalysts at the atomic structure level. Angew. Chem. Int. Ed. 2024, accepted. S. Meng, H. Du, X. Li, X. Zheng, P. Zhao, Z. Yuan, S. Huang, Y. L. Zhao, L. Dai, An adjuvant micelle-based multifunctional nanosystem for tumor immunotherapy by remodeling three types of immunosuppressive cells. ACS Nano 2024, 18, 3134-3150. B. Mi, Y. Xiong, Y. Zhao, Z. Lin, L. Lu, G. Liu, Y. L. Zhao, Metal–organic framework-integrated composites for bone tissue regeneration. Adv. Funct. Mater. 2024, accepted. L. Ma, Y. Cheng, X. Feng, X. Zhang, J. Lei, H. Wang, Y. Xu, B. Tong, D. Zhu, D. Wu, X. Zhou, H. Liang, K. Zhao, K. Wang, L. Tan, Y. L. Zhao, C. Yang, A Janus-ROS healing system promoting infectious bone regeneration via sono-epigenetic modulation. Adv. Mater. 2024, 36, 2307846. Z. Li, S. Cao, Y. Zheng, L. Song, H. Zhang, Y. L. Zhao, Colorful ultralong room temperature phosphorescent afterglow with excitation wavelength dependence based on boric acid matrix. Adv. Funct. Mater. 2024, 34, 2306956. Y. Xiong, Q. Feng, L. Lu, X. Qiu, S. Knoedler, A. C. Panayi, D. Jiang, Y. Rinkevich, Z. Lin, B. Mi, G. Liu, Y. L. Zhao, Metal–organic frameworks and their composites for chronic wound healing: from bench to bedside. Adv. Mater. 2024, 36, 2302587. D. Jana, B. He, Y. Chen, J. Liu, Y. L. Zhao, A Defect-engineered nanozyme for targeted NIR-II photothermal immunotherapy of cancer. Adv. Mater. 2024, accepted. B. Mi, Y. Xiong, L. Lu, J. Liao, G. Liu, Y. L. Zhao, Macrophage-mediated fracture healing: Unraveling molecular mechanisms and therapeutic implications using hydrogel-based interventions. Biomaterials 2024, 305, 122461. W. Yuan, L. Chen, C. Yuan, Z. Zhang, X. Chen, X. Zhang, J. Guo, C. Qian, Z. Zhao, Y. L. Zhao, Cooperative supramolecular polymerization of styrylpyrenes for color-dependent circularly polarized luminescence and photocycloaddition. Nat. Commun. 2023, 14, 8022. C. Qian, W. L. Teo, Q. Gao, H. Wu, Y. Liao, Y. L. Zhao, Polycrystalline covalent organic frameworks. Mater. Today 2023, 71, 91-107. L. Gao, J. Huang, L. Qu, X. Chen, Y. Zhu, C. Li, Q. Tian, Y. L. Zhao, C. Yang, Stepwise taming of triplet excitons via multiple confinements in intrinsic polymers for long-lived room-temperature phosphorescence. Nat. Commun. 2023, 14, 7252. L. Yang, D. Zhang, W. Li, H. Lin, C. Ding, Q. Liu, L. Wang, Z. Li, L. Mei, H. Chen, Y. L. Zhao, X. Zeng, Biofilm microenvironment triggered self-enhancing photodynamic immunomodulatory microneedle for diabetic wound therapy. Nat. Commun. 2023, 14, 7658. G. Zhou, W. Zhong, Y. Chen, Y. Wang, T. Li, J. Hua, Y. Zhou, M. Li, N. Gu, Y. L. Zhao, Mixed-valence gold-porphyrin two-dimensional coordination networks for repurposing of chrysotherapy. Biomaterials 2023, 302, 122361. Z. Shi, M. Luo, Q. Huang, C. Ding, W. Wang, Y. Wu, J. Luo, C. Lin, T. Chen, X. Zeng, L. Mei, Y. L. Zhao, H. Chen, NIR-dye bridged human serum albumin reassemblies for effective photothermal therapy of tumor. Nat. Commun. 2023, 14, 6567. Y. Dong, S. Dong, C. Yu, J. Liu, S. Gai, Y. Xie, Z. Zhao, X. Qin, L. Feng, P. Yang, Y. L. Zhao, Mitochondria-targeting Cu3VS4 nanostructure with high copper ionic mobility for photothermoelectric therapy. Sci. Adv. 2023, 9, adi9980. S. Wang, T. Wu, S. Wu, J. Guo, T. He, Y. Wu, W. Yuan, Z. Zhang, Y. Hua, Y. L. Zhao, Cobaloxime-integrated covalent organic frameworks for photocatalytic hydrogen evolution coupled with alcohol oxidation. Angew. Chem. Int. Ed. 2023, 62, e202311082. K. Zha, Y. Xiong, W. Zhang, M. Tan, W. Hu, Z. Lin, P. Cheng, L. Lu, K. Cai, B. Mi, Q. Feng, Y. L. Zhao, G. Liu, Waste to wealth: near-infrared/pH dual-responsive copper-humic acid hydrogel films for bacteria-infected cutaneous wound healing. ACS Nano 2023, 17, 17199-17216. Y. Zhao, D. Wang, T. Qian, J. Zhang, Z. Li, Q. Gong, X. Ren, Y. L. Zhao, Biomimetic nanozyme-decorated hydrogels with H2O2-activated oxygenation for modulating immune microenvironment in diabetic wound. ACS Nano 2023, 17, 16854-16869. Y. Chen, M. Zuo, Y. Chen, P. Yu, X. Chen, X. Zhang, W. Yuan, Y. Wu, W. Zhu, Y. L. Zhao, Nanocompartment-confined polymerization in living systems. Nat. Commun. 2023, 14, 5229. C. Qin, X. Wu, L. Tang, X. Chen, M. Li, Y. Mou, B. Su, S. Wang, C. Feng, J. Liu, X. Yuan, Y. L. Zhao, H. Wang, Dual donor-acceptor covalent organic frameworks for hydrogen peroxide photosynthesis. Nat. Commun. 2023, 14, 5238. B. Luo, W. Wang, Y. Zhao, Y. L. Zhao, Hot-electron dynamics mediated medical diagnosis and therapy. Chem. Rev. 2023, 123, 10808-10833. T. He, R. Liu, S. Wang, I. K. W. On, Y. Wu, Y. Xing, W. Yuan, J. Guo, Y. L. Zhao, Bottom-up design of photoactive chiral covalent organic frameworks for visible light-driven asymmetric catalysis. J. Am. Chem. Soc. 2023, 145, 18015-18021. Y. Wu, L. Sun, X. Chen, J. Liu, J. Ouyang, X. Zhang, Y. Guo, Y. Chen, W. Yuan, D. Wang, T. He, F. Zeng, H. Chen, S. Wu, Y. L. Zhao, Cucurbit[8]uril-based water-dispersible assemblies with enhanced optoacoustic performance for multispectral optoacoustic imaging. Nat. Commun. 2023, 14, 3918. K. Zhang, Y. Long, Z. Ma, S. Li, Y. L. Zhao, H. Han, Artificial nanoplatelet regulation of tumor immune microenvironment to inhibit post-surgical tumor recurrence and lung metastasis. Mater. Today 2023, 67, 68-83. D. Wang, J. Liu, C. Wang, W. Zhang, G. Yang, Y. Chen, X. Zhang, Y. Wu, L. Gu, H. Chen, W. Yuan, X. Chen, G. Liu, B. Gao, Q. Chen, Y. L. Zhao, Microbial synthesis of Prussian blue for potentiating checkpoint blockade immunotherapy. Nat. Commun. 2023, 14, 2943. G. Liu, M. G. Humphrey, C. Zhang, Y. L. Zhao, Self-assembled stereomutation with supramolecular chirality inversion. Chem. Soc. Rev. 2023, 52, 4443-4487. Q. Zhou, C. Yang, Y. L. Zhao, Dynamic organic room-temperature phosphorescent systems. Chem 2023, 9, 2446-2480. T. He, Y. L. Zhao, Covalent organic frameworks for energy conversion in photocatalysis. Angew. Chem. Int. Ed. 2023, 62, e202303086. D. Wang, L. Zhang, C. Wang, Z. Cheng, W. Zheng, P. Xu, Q. Chen, Y. L. Zhao, Missing-linker-confined single-atomic Pt nanozymes for enzymatic theranostics of tumor. Angew. Chem. Int. Ed. 2023, 62, e202217995. J. Guo, J. Li, T. Wu, X. Peng, S. Wang, Z. Zhao, Y. Hua, B. Z. Tang, Y. L. Zhao, Free radical-mediated intramolecular photocyclization of AIEgens based on 2,3-diphenylbenzo[b]thiophene S,S-dioxide. J. Am. Chem. Soc. 2023, 145, 7837–7844. T. He, Z. Zhao, R. Liu, X. Liu, B. Ni, Y. Wei, Y. Wu, W. Yuan, H. Peng, Z. Jiang, Y. L. Zhao, Porphyrin-based covalent organic frameworks anchoring Au single atoms for photocatalytic nitrogen fixation. J. Am. Chem. Soc. 2023, accepted. X. Xiong, Y. Chen, Z. Wang, H. Liu, M. Le, C. Lin, G. Wu, L. Wang, X. Shi, Y.-G. Jia, Y. L. Zhao, Polymerizable rotaxane hydrogels for three-dimensional printing fabrication of wearable sensors. Nat. Commun. 2023, accepted. Z. Zhang, Z. Wang, X. Liu, Y.-e Shi, Z. Li, Y. L. Zhao, Modulating emission of boric acid into highly efficient and color-tunable afterglow via dehydration-induced through-space conjugation. Adv. Sci. 2023, accepted. A. K. Bindra, D. Wang, Y. L. Zhao, Metal-organic frameworks meet polymers: from synthesis strategies to healthcare applications. Adv. Mater. 2023, accepted. L. Feng, R. Zhao, L. Yang, B. Liu, S. Dong, C. Qian, J. Liu, Y. L. Zhao, Tumor-specific NIR-activatable nanoreactor for self-enhanced multimodal imaging and cancer phototherapy. ACS Nano 2023, 17, 1622-1637. D. Jana, B. He, Y. Chen, J. Liu, Y. L. Zhao, Defect-engineered nanozyme for targeted NIR-II photothermal immunotherapy of cancer. Adv. Mater. 2023, accepted. X. Shan, W. Chi, H. Jiang, Z. Luo, C. Qian, H. Wu, Y. L. Zhao, Monomer and excimer emission in a conformational and stacking-adaptable molecular system. Angew. Chem. Int. Ed. 2023, 62, e202215652. Z. Ma, H. Han, Y. L. Zhao, Mitochondrial dysfunction-targeted nanosystems for precise tumor therapeutics. Biomaterials 2023, 293, 121947. T.-X. Luan, L. Du, J.-R. Wang, K. Li, Q. Zhang, P.-Z. Li, Y. L. Zhao, Highly effective generation of singlet oxygen by an imidazole-linked robust photosensitizing covalent organic framework. ACS Nano 2022, 16, 21565-21575. M. Guo, J. T. Brewster II, H. Zhang, Y. Zhao, Y. L. Zhao, Challenges and opportunities of chemiresistors based on micro-electro-mechanical systems for chemical olfaction. ACS Nano 2022, 16, 17778-17801. K. Zhang, Z. Ma, S. Li, W. Zhang, M. F. Foda, Y. L. Zhao, H. Han, Platelet-covered nanocarriers for targeted delivery of hirudin to eliminate thrombotic complication in tumor therapy. ACS Nano 2022, 16, 18483-18496. Y. Zhao, S. Song, D. Wang, H. Liu, J. Zhang, Z. Li, J. Wang, X. Ren, Y. L. Zhao, Nanozyme-reinforced hydrogel as a H2O2-driven oxygenerator for enhancing prosthetic interface osseointegration in rheumatoid arthritis therapy. Nat. Commun. 2022, 13, 6758. Y. Yu, Q. Cheng, X. Ji, H. Chen, W. Zeng, X. Zeng, Y. L. Zhao, L. Mei, Engineered drug-loaded cellular membrane nanovesicles for efficient treatment of post-surgical cancer recurrence and metastasis. Sci. Adv. 2022, 8, add3599. M. Chang, Z. Hou, M. Wang, D. Wen, C. Li, Y. Liu, Y. L. Zhao, J. Lin, Cu single atom nanozyme based high-efficiency mild photothermal therapy through cellular metabolic regulation. Angew. Chem. Int. Ed. 2022, 61, e202209245. C. Qian, L. Feng, W. L. Teo, J. Liu, W. Zhou, D. Wang, Y. L. Zhao, Imine and imine-derived linkages in two-dimensional covalent organic frameworks. Nat. Rev. Chem. 2022, 6, 881-898. X. Chen, X. Zhang, Y. Wu, Y. Chen, Y. Guo, D. Jana, D. Wang, W. Yuan, Y. L. Zhao, Tumor extracellular matrix-targeted nanoscavengers reverse suppressive microenvironment for cocktail therapy. Mater. Today 2022, 61, 78-90. Z. Ma, M. Yang, M. F. Foda, K. Zhang, S. Li, H. Liang, Y. L. Zhao, H. Han, Polarization of tumor-associated macrophages promoted by vitamin C-loaded liposomes for cancer immunotherapy. ACS Nano 2022, 16, 17389-17401. C. Ding, C. Chen, X. Zeng, H. Chen, Y. L. Zhao, Emerging strategies in stimuli-responsive prodrug nanosystems for cancer therapy. ACS Nano 2022, 16, 13513-13553. C. You, X. Li, D. Wang, H. Chen, L. Liang, Y. Chen, Y. L. Zhao, H. Xiang, Self-assembled aza-boron-dipyrromethene for ferroptosis-boosted sonodynamic therapy. Angew. Chem. Int. Ed. 2022, 61, e202210174. J. Liu, F. You, B. He, Y. Wu, D. Wang, W. Zhou, C. Qian, G. Yang, G. Liu, H. Wang, Y. Guo, L. Gu, L. Feng, S. Li, Y. L. Zhao, Directing the architecture of surface-clean Cu2O for CO electroreduction. J. Am. Chem. Soc. 2022, 144, 12410-12420. Y. Zhao, H. Zhang, S. Zhang, Y. L. Zhao, Toward highly trustable miniaturized semiconductor gas sensors. Matter 2022, 5, 1985-1989. S. Liu, W. Li, H. Chen, J. Zhou, S. Dong, P. Zang, B. Tian, H. Ding, S. Gai, P. Yang, Y. L. Zhao, On-demand generation of peroxynitrite from an integrated two-dimensional system for enhanced tumor therapy. ACS Nano 2022, 16, 8939-8953. L. Dai, M. Yao, Z. Fu, X. Li, X. Zheng, S. Meng, Z. Yuan, K. Cai, H. Yang, Y. L. Zhao, Multifunctional metal-organic framework-based nanoreactor for starvation/oxidation improved indoleamine 2,3-dioxygenase-blockade tumor immunotherapy. Nat. Commun. 2022, 13, 2688. Z. Wang, L. Gao, Y. Zheng, Y. Zhu, Y. Zhang, X. Zheng, C. Wang, Y. Li, Y. L. Zhao, C. Yang, Four-in-one stimulus-responsive long-lived luminescent systems based on pyrene-doped amorphous polymers. Angew. Chem. Int. Ed. 2022, 61, e202203254. J. Guo, C. Yang, Y. L. Zhao, Long-lived organic room-temperature phosphorescence from amorphous polymer systems. Acc. Chem. Res. 2022, 55, 1160-1170. K. Zhang, Z. Ma, S. Li, Y. Wu, J. Zhang, W. Zhang, Y. L. Zhao, H. Han, Disruption of dual homeostasis by a metal-organic framework nanoreactor for ferroptosis-based immunotherapy of tumor. Biomaterials 2022, 284, 121502. Y. Chen, P. He, D. Jana, D. Wang, M. Wang, P. Yu, W. Zhu, Y. L. Zhao, Glutathione-depleting organic metal adjuvants for effective NIR-II photothermal immunotherapy. Adv. Mater. 2022, 34, 2201706. Y. Zhang, X. Chen, J. Xu, Q. Zhang, L. Gao, Z. Wang, L. Qu, K. Wang, Y. Li, Z. Cai, Y. L. Zhao, C. Yang, Cross-linked polyphosphazene nanospheres boosting long-lived organic room temperature phosphorescence. J. Am. Chem. Soc. 2022, 144, 6107-6117. Z. Zong, A. Hao, P. Xing, Y. L. Zhao, Chiral molecular nanosilicas. Chem. Sci. 2022, 13, 4029-4040. F. Yang, R. Li, W. Wei, X. Ding, Z. Xu, P. Wang, G. Wang, Y. Xu, H. Fu, Y. L. Zhao, Water-soluble doubly-strapped isolated perylene diimide chromophore. Angew. Chem. Int. Ed. 2022, 61, e202202491. X. Zhang, X. Chen, Y. L. Zhao, Nanozymes: versatile platforms for cancer diagnosis and therapy. Nano-Micro Lett. 2022, 14, 95. Y. Li, M. Li, L. Liu, C. Xue, Y. Fei, X. Wang, Y. Zhang, K. Cai, Y. L. Zhao, Z. Luo, Cell-specific metabolic reprogramming of tumors for bioactivatable ferroptosis therapy. ACS Nano 2022, 16, 3965-3984. G. Yang, D. Wang, S. Z. F. Phua, A. K. Bindra, C. Qian, R. Zhang, L. Cheng, G. Liu, H. Wu, Z. Liu, Y. L. Zhao, Albumin-based therapeutics capable of glutathione consumption and hydrogen peroxide generation for synergetic chemodynamic and chemotherapy of cancer. ACS Nano 2022, 16, 2319-2329. H. Wang, Y. Yang, X. Yuan, W. L. Teo, Y. Wu, L. Tang, Y. L. Zhao, Structure-performance correlation guided applications of covalent organic frameworks. Mater. Today 2022, 53, 106-133. C. Wang, Y. Zhang, Z. Wang, Y. Zheng, X. Zheng, L. Gao, Q. Zhou, J. Hao, B. Pi, Q. Li, C. Yang, Y. Li, K. Wang, Y. L. Zhao, Photo-induced dynamic room temperature phosphorescence based on triphenyl phosphonium containing polymers. Adv. Funct. Mater. 2022, 32, 2111941. Y. Zhao, S. Song, X. Ren, J. Zhang, Q. Lin, Y. L. Zhao, Supramolecular adhesive hydrogels for tissue engineering applications. Chem. Rev. 2022, 122, 5604-5640. Q. Zhang, M. He, X. Zhang, H. Yu, J. Liu, Y. Guo, J. Zhang, X. Ren, H. Wang, Y. L. Zhao, Tumor microenvironment activated chemodynamic-photodynamic therapy by multistage self-assembly engineered protein nanomedicine. Adv. Funct. Mater. 2022, 32, 2112251. S. Dong, Y. Dong, B. Liu, J. Liu, S. Liu, Z. Zhao, W. Li, B. Tian, R. Zhao, F. He, S. Gai, Y. Xie, P. Yang, Y. L. Zhao, Guiding transition metal-doped hollow cerium tandem nanozymes with elaborately regulated multi-enzymatic activities for intensive chemodynamic therapy. Adv. Mater. 2022, 34, 2107054. A. K. Bindra, S. Sreejith, R. Prasad, M. Gorain, R. Thomas, D. Jana, M. H. Nai, D. Wang, A. Tharayil, G. C. Kundu, R. Srivastava, S. Thomas, C. T. Lim, Y. L. Zhao, A plasmonic supramolecular nanohybrid as a contrast agent for site-selective computed tomography imaging of tumor. Adv. Funct. Mater. 2022, 32, 2110575. G. Dong, P. Qiu, Q. Chen, C. Huang, F. Chen, X. Liu, Z. Li, Y. Wang, Y. L. Zhao, K+-intercalated carbon nitride with electron storage property for high-efficiency visible light driven nitrogen fixation. Chem. Eng. J. 2022, 433, 133573. J. Chen, L. Chen, Y. Wu, Y. Fang, F. Zeng, S. Wu, Y. L. Zhao, A H2O2-activatable nanoprobe for diagnosing interstitial cystitis and liver ischemia-reperfusion injury via multispectral optoacoustic tomography and NIR-II fluorescent imaging. Nat. Commun. 2021, 12, 6870. L. Gu, W. Ye, X. Liang, A. Lv, H. Ma, M. Singh, W. Jia, Z. Shen, Y. Guo, Y. Gao, H. Chen, D. Wang, Y. Wu, J. Liu, H. Wang, Y.-X. Zheng, Z. An, W. Huang, Y. L. Zhao, Circularly polarized organic room temperature phosphorescence from amorphous copolymers. J. Am. Chem. Soc. 2021, 143, 18527-18535. W. Zhang, J. Liu, X. Li, Y. Zheng, L. Chen, D. Wang, M. F. Foda, Z. Ma, Y. L. Zhao, H. Han, Precise chemodynamic therapy of cancer by trifunctional bacterium-based nanozymes. ACS Nano 2021, 15, 19321-19333. A. K. Bindra, D. Wang, Z. Zheng, D. Jana, W. Zhou, S. Yan, H. Wu, Y. Zheng, Y. L. Zhao, Self-assembled semiconducting polymer based hybrid nanoagents for synergistic tumor treatment. Biomaterials 2021, 279, 121188. D. Wang, I. W. He, J. Liu, D. Jana, Y. Wu, X. Zhang, C. Qian, Y. Guo, X. Chen, A. K. Bindra, Y. L. Zhao, Missing-linker-assisted artesunate delivery by metal-organic frameworks for synergistic cancer treatment. Angew. Chem. Int. Ed. 2021, 60, 26254-26259. Y. Li, G. V. Baryshnikov, C. Xu, H. Ågren, L. Zhu, T. Yi, Y. L. Zhao, H. Wu, Photoinduced radical emission in a coassembly system. Angew. Chem. Int. Ed. 2021, 60, 23842-23848. D. Wang, Y. L. Zhao, Single-atom engineering of metal-organic frameworks toward healthcare. Chem 2021, 7, 2635-2671. Y. Zhang, Y. Su, H. Wu, Z. Wang, C. Wang, Y. Zheng, X. Zheng, L. Gao, Q. Zhou, Y. Yang, X. Chen, C. Yang, Y. L. Zhao, Large-area, flexible, transparent, and long-lived polymer-based phosphorescence films. J. Am. Chem. Soc. 2021, 143, 13675-13685. Z. Ma, Y. Zhang, X. Dai, W. Zhang, M. F. Foda, J. Zhang, Y. L. Zhao, H. Han, Selective thrombosis of tumor for enhanced hypoxia-activated prodrug therapy. Adv. Mater. 2021, 33, 2104504. Z. Ma, M. F. Foda, H. Liang, Y. L. Zhao, H. Han, In situ nanozyme-amplified NIR-II phototheranostics for tumor-specific imaging and therapy. Adv. Funct. Mater. 2021, 31, 2103765. Y. Zhang, R. Zhao, J. Liu, H. Kong, K. Zhang, Y.-N. Zhang, X. Kong, Q. Zhang, Y. L. Zhao, Hierarchical nano-to-molecular disassembly of boron dipyrromethene nanoparticles for enhanced tumor penetration and activatable photodynamic therapy. Biomaterials 2021, 275, 120945. B. Lu, Y. Bo, M. Yi, Z. Wang, J. Zhang, Z. Zhu, Y. L. Zhao, J. Zhang, Enhancing the solubility and transdermal delivery of drugs using ionic liquid-in-oil microemulsions. Adv. Funct. Mater. 2021, 31, 2102794. Y. Wu, F. Zeng, Y. L. Zhao, S. Wu, Emerging contrast agents for multispectral optoacoustic imaging and their biomedical applications. Chem. Soc. Rev. 2021, 50, 7924-7940. C. Wiraja, Y. L. Zhao, Toward miniaturizing microelectronics using covalent organic framework dielectric. Matter 2021, 4, 1760-1762. Y.-X. Ma, B. Gao, J. He, J.-F. Ma, Y. L. Zhao, Hydrogen bonded metal–organic supramolecule functionalized BiVO4 photoanode for enhanced water oxidation efficiency. Chem. Eng. J. 2021, 422, 130092. Q. Zhang, J. Zhang, J. Song, Y. Liu, X. Ren, Y. L. Zhao, Protein-based nanomedicine for therapeutic benefits of cancer. ACS Nano 2021, 15, 8001-8038. D. Jana, D. Wang, A. K. Bindra, Y. Guo, J. Liu, Y. L. Zhao, Ultrasmall alloy nanozyme for ultrasound- and near-Infrared light-promoted tumor ablation. ACS Nano 2021, 15, 7774-7782. B. Tian, S. Liu, L. Feng, S. Liu, S. Gai, Y. Dai, L. Xie, B. Liu, P. Yang, Y. L. Zhao, Renal-clearable nickel-doped carbon dots with boosted photothermal conversion efficiency for multimodal imaging-guided cancer therapy in the second near-infrared biowindow. Adv. Funct. Mater. 2021, 31, 2100549. X. Deng, W. Yang, Z. Shao, Y. L. Zhao, Genetically modified bacteria for targeted phototherapy of tumor. Biomaterials 2021, 272, 120809. X. Zhang, X. Chen, Y. Guo, G. Gao, D. Wang, Y. Wu, J. Liu, G. Liang, Y. L. Zhao, F.-G. Wu, Dual gate-controlled therapeutics for overcoming bacterium-induced drug resistance and potentiating cancer immunotherapy. Angew. Chem. Int. Ed. 2021, 60, 14013-14021. Y. Zhang, L. Gao, X. Zheng, Z. Wang, C. Yang, H. Tang, L. Qu, Y. Li, Y. L. Zhao, Ultraviolet irradiation-responsive dynamic ultralong organic phosphorescence in polymeric systems. Nat. Commun. 2021, 12, 2297. G. Zuo, Y. Wang, W. L. Teo, Q. Xian, Y. L. Zhao, Direct Z-scheme TiO2–ZnIn2S4 nanoflowers for cocatalyst-free photocatalytic water splitting. Appl. Catal. B 2021, 291, 120126. J. Liang, A. Hao, P. Xing, Y. L. Zhao, Inverse evolution of helicity from molecular to macroscopic level based on N-terminal aromatic amino acids. ACS Nano 2021, 15, 5322-5332. B. He, S. Jia, M. Zhao, Y. Wang, T. Chen, S. Zhao, Z. Li, Z. Lin, Y. L. Zhao, X. Liu, General and robust photothermal heating-enabled high-efficiency photoelectrochemical water splitting. Adv. Mater. 2021, 33, 2004406. Z. Li, X. Liu, G. Wang, B. Li, H. Chen, H. Li, Y. L. Zhao, Photoresponsive supramolecular coordination polyelectrolyte as smart anticounterfeiting inks. Nat. Commun. 2021, 12, 1363. W. L. Teo, W. Zhou, C. Qian, Y. L. Zhao, Industrializing metal-organic frameworks: scalable synthetic means and their transformation into functional materials. Mater. Today 2021, 47, 170-186. H. Xiang, L. Zhao, L. Yu, H. Chen, C. Wei, Y. Chen, Y. L. Zhao, Self-assembled organic nanomedicine enables ultrastable photo-to-heat converting theranostics in the second near infrared biowindow. Nat. Commun. 2021, 12, 218. D. Wang, H. Wu, C. Wang, L. Gu, H. Chen, D. Jana, L. Feng, J. Liu, X. Wang, P. Xu, Z. Guo, Q. Chen, Y. L. Zhao, Self-assembled single-site nanozyme for tumor-specific amplified cascade enzymatic therapy. Angew. Chem. Int. Ed. 2021, 60, 3001-3007. L. Feng, B. Liu, R. Xie, D. Wang, C. Qian, W. Zhou, J. Liu, D. Jana, P. Yang, Y. L. Zhao, An ultrasmall SnFe2O4 nanozyme with endogenous oxygen generation and glutathione depletion for synergistic cancer therapy. Adv. Funct. Mater. 2021, 31, 2006216. X. Deng, Z. Shao, Y. L. Zhao, Solutions to the drawbacks of photothermal and photodynamic cancer therapy. Adv. Sci. 2021, 8, 2002504. G. Zuo, Y. Wang, W. L. Teo, A. Xie, Y. Guo, Y. Dai, W. Zhou, D. Jana, Q. Xian, W. Dong, Y. L. Zhao, Enhanced photocatalytic water oxidation by hierarchical 2D-Bi2MoO6@2D-MXene Schottky junction nanohybrid. Chem. Eng. J. 2021, 403, 126328. C. Qian, W. Zhou, J. Qiao, D. Wang, X. Li, W. L. Teo, X. Shi, H. Wu, J. Di, H. Wang, G. Liu, L. Gu, J. Liu, L. Feng, Y. Liu, S. Y. Quek, K. P. Loh, Y. L. Zhao, Linkage engineering by harnessing supramolecular interactions to fabricate 2D hydrazone-linked covalent organic framework platforms toward advanced catalysis. J. Am. Chem. Soc. 2020, 142, 18138-18149. X. Liu, L. Xiao, J. Weng, Q. Xu, W. Li, C. Zhao, J. Xu, Y. L. Zhao, Regulating the reactivity of black phosphorus via protective chemistry. Sci. Adv. 2020, 6, eabb4359. D. Wang, H. Wu, G. Yang, C. Qian, L. Gu, H. Wang, W. Zhou, J. Liu, Y. Wu, X. Zhang, Z. Guo, H. Chen, D. Jana, Y. L. Zhao, Metal-organic framework derived multicomponent nanoagent as a reactive oxygen species amplifier for enhanced photodynamic therapy. ACS Nano 2020, 14, 13500-13511. Y. Liu, W. Zhou, W. L. Teo, K. Wang, L. Zhang, Y. Zeng, Y. L. Zhao, Covalent-organic-framework-based composite materials. Chem 2020, 6, 3172-3202. X. Zhang, X. Chen, J. Song, J. Zhang, X. Ren, Y. L. Zhao, Size-transformable nanostructures: from design to biomedical applications. Adv. Mater. 2020, 32, 2003752. X. Wang, M. Li, Y. Hou, Y. Li, X. Yao, C. Xue, Y. Fei, Y. Xiang, K. Cai, Y. L. Zhao, Z. Luo, Tumor-microenvironment-activated in situ self-assembly of sequentially responsive biopolymer for targeted photodynamic therapy. Adv. Funct. Mater. 2020, 30, 2000229. D. Wang, D. Jana, Y. L. Zhao, Metal-organic framework derived nanozymes in biomedicine. Acc. Chem. Res. 2020, 53, 1389-1400. X. Wei, D. Zheng, M. Zhao, H. Chen, X. Fan, B. Gao, L. Gu, Y. Guo, J. Qin, J. Wei, Y. L. Zhao, G. Zhang, Cross-linked polyphosphazene hollow nanosphere derived N/P doped porous carbon with single nonprecious metal atoms for oxygen reduction reaction. Angew. Chem. Int. Ed. 2020, 59, 14639-14646. H. Zhang, Z. Liu, F. Xin, Y. L. Zhao, Metal-ligated pillararene materials: from chemosensors to multidimensional self-assembled architectures. Coord. Chem. Rev. 2020, 420, 213425. L. Feng, S. Gai, F. He, P. Yang, Y. L. Zhao, Multifunctional bismuth ferrite nanocatalysts with optical and magnetic functions for ultrasound enhanced tumor theranostics. ACS Nano 2020, 14, 7245-7258. L. Sun, X. He, Y. Yuan, J. Chen, W. Zhan, X.-J. Wang, Y. L. Zhao, X. Han, Tuning interfacial sequence between nitrogen-doped carbon layer and Au nanoparticles on metal-organic framework-derived TiO2 to enhance photocatalytic hydrogen production. Chem. Eng. J. 2020, 397, 125468. L. Sun, Y. Yuan, F. Wang, Y. L. Zhao, W. Zhan, X. Han, Selective wet-chemical etching to create TiO2@MOF frame heterostructure for efficient photocatalytic hydrogen evolution. Nano Energy 2020, 74, 104909. Y. Liu, S. Wang, X. Meng, Y. Ye, X. Song, Z. Liang, Y. L. Zhao, Molecular expansion for constructing porous organic polymers with high surface areas and well-defined nanopores. Angew. Chem. Int. Ed. 2020, 59, 19487-19493. G. Zuo, Y. Wang, W. L. Teo, A. Xie, Y. Guo, Y. Dai, W. Zhou, D. Jana, Q. Xian, W. Dong, Y. L. Zhao, Ultrathin ZnIn2S4 nanosheets anchored on Ti3C2Tx MXene for photocatalytic H2 evolution. Angew. Chem. Int. Ed. 2020, 59, 11287-11292. B. Han, Z. Duan, J. Xu, Y. Zhu, Q. Xu, H. Wang, H. Tai, J. Weng, Y. L. Zhao, The art of integrated functionalization: super stable black phosphorus achieved through metal-organic framework coating. Adv. Funct. Mater. 2020, 30, 2002232. C. C. Xue, M. H. Li, Y. Zhao, J. Zhou, Y. Hu, K. Y. Cai, Y. L. Zhao, S. H. Yu, Z. Luo, Tumor microenvironment-activatable Fe-doxorubicin preloaded amorphous CaCO3 nanoformulation triggers ferroptosis in target tumor cells. Sci. Adv. 2020, 6, eaax1346. H. Wang, C. Qian, J. Liu, Y. Zeng, D. Wang, W. Zhou, L. Gu, H. Wu, G. Liu, Y. L. Zhao, Integrating suitable linkage of covalent organic frameworks into covalently bridged inorganic/organic hybrids toward efficient photocatalysis. J. Am. Chem. Soc. 2020, 142, 4862-4871. L. Gu, H. Wu, H. Ma, W. Ye, W. Jia, H. Wang, H. Chen, N. Zhang, D. Wang, C. Qian, Z. An, W. Huang, Y. L. Zhao, Color-tunable ultralong organic room temperature phosphorescence from a multicomponent copolymer. Nat. Commun. 2020, 11, 944. T. Zhang, X. Ma, H. Wu, L. Zhu, Y. L. Zhao, H. Tian, Molecular engineering for metal-free amorphous room-temperature phosphorescent materials. Angew. Chem. Int. Ed. 2020, 59, 11206-11216. Z. Wang, Y. Zhang, C. Wang, X. Zheng, Y. Zheng, L. Gao, C. Yang, Y. Li, L. Qu, Y. L. Zhao, Color-tunable polymeric long-persistent luminescence based on polyphosphazenes. Adv. Mater. 2020, 32, 1907355. D. Wang, H. Wu, S. Z. F. Phua, G. Yang, W. Q. Lim, L. Gu, C. Qian, H. Wang, Z. Guo, H. Chen, Y. L. Zhao, Self-assembled single-atom nanozyme form enhanced photodynamic therapy treatment of tumor. Nat. Commun. 2020, 11, 357. L. Zhao, J. Li, Y. Su, L. Yang, L. Chen, L. Qiang, Y. Wang, H. Xiang, H. P. Tham, J. Peng, Y. L. Zhao, MTH1 inhibitor amplifies the lethality of reactive oxygen species to tumor in photodynamic therapy. Sci. Adv. 2020, 6, eaaz0575. Y. Su, Y. Zhang, Z. Wang, W. Gao, P. Jia, D. Zhang, C. Yang, Y. Li, Y. L. Zhao, Excitation-dependent long-life luminescent polymeric systems under ambient conditions. Angew. Chem. Int. Ed. 2020, 59, 9967-9971. L. Sun, Y. Zhuang, Y. Yuan, W. Zhan, X. J. Wang, X. Han, Y. L. Zhao, Nitrogen-doped carbon-coated CuO-In2O3 p-n heterojunction for remarkable photocatalytic hydrogen evolution. Adv. Energy Mater. 2019, 9, 1902839. H. Wang, H. Shi, W. Ye, X. Yao, Q. Wang, C. Dong, W. Jia, H. Ma, S. Cai, K. Huang, L. Fu, Y. Zhang, J. Zhi, L. Gu, Y. L. Zhao, Z. An, W. Huang, Amorphous ionic polymers with color-tunable ultralong organic phosphorescence. Angew. Chem. Int. Ed. 2019, 58, 18776-18782. Y. Zhai, G. Liu, F. Jin, Y. Zhang, X. Gong, Z. Miao, J. Li, M. Zhang, Y. Cui, L. Zhang, Y. Liu, H. Zhang, Y. L. Zhao, Y. Zeng, Construction of covalent-organic frameworks (COFs) from amorphous covalent organic polymers via linkage replacement. Angew. Chem. Int. Ed. 2019, 58, 17679-17683. X. Liu, Y. Bai, J. Xu, Q. Xu, L. Xiao, L. Sun, J. Weng, Y. L. Zhao, Robust amphiphobic few-layer black phosphorus nanosheet with improved stability. Adv. Sci. 2019, 6, 1901991. W. Cheng, X. Zeng, H. Chen, Z. Li, W. Zeng, L. Mei, Y. L. Zhao, Versatile polydopamine platforms: synthesis and promising applications for surface modification and advanced nanomedicine. ACS Nano 2019, 13, 8537-8565. Z. Li, H. Chen, B. Li, Y. Xie, X. Gong, X. Liu, H. Li, Y. L. Zhao, Photoresponsive luminescent polymeric hydrogels for reversible information encryption and decryption. Adv. Sci. 2019, 6, 1901529. Y. Wang, S. Z. F. Phua, G. Dong, X. Liu, B. He, Q. Zhai, Y. Li, C. Zheng, H. Quan, Z. Li, Y. L. Zhao, Structure tuning of polymeric carbon nitride for solar energy conversion: from nano to molecular scale. Chem 2019, 5, 2775-2813. H. Wu, Z. Chen, W. Chi, B. A. Kaur, L. Gu, C. Qian, B. Wu, B. Yue, G. Liu, G. Yang, L. Zhu, Y. L. Zhao, Structural engineering of luminogens with high emission efficiency both in solution and the solid state. Angew. Chem. Int. Ed. 2019, 58, 11419-11423. P. Xing, Y. Li, S. Xue, S. Z. F. Phua, C. Ding, H. Chen, Y. L. Zhao, Occurrence of chiral nanostructures induced by multiple hydrogen bonds. J. Am. Chem. Soc. 2019, 141, 9946-9954. G. Liu, C. Zhou, W. L. Teo, C. Qian, Y. L. Zhao, Self-sorting double-network hydrogels with tunable supramolecular handedness and mechanical property. Angew. Chem. Int. Ed. 2019, 58, 9366-9372. H. Wu, Y. L. Zhao, Colour-tunable ultralong emission. Nat. Photonics 2019, 13, 373-375. D. Wang, H. Wu, W. Q. Lim, S. Z. F. Phua, P. Xu, Q. Chen, Z. Guo, Y. L. Zhao, A mesoporous nanoenzyme derived from metal-organic frameworks with endogenous oxygen generation to alleviate tumor hypoxia for significantly enhanced photodynamic therapy. Adv. Mater. 2019, 31, 1901893. L. Sun, R. Li, W. Zhan, Y. Yuan, X. Wang, X. Han, Y. L. Zhao, Double-shelled hollow rods assembled from nitrogen/sulfur-codoped carbon coated indium oxide nanoparticles as excellent photocatalysts. Nat. Commun. 2019, 10, 2270. Y. Liu, Q. Chen, C. Mou, L. Pan, X. Duan, X. Chen, H. Chen, Y. L. Zhao, Y. Lu, Z. Jin, Y. R. Chi, Catalytic asymmetric acetalization of carboxylic acids for access to chiral phthalidyl ester prodrugs. Nat. Commun. 2019, 10, 1675. G. Yang, S. Z. F. Phua, W. Q. Lim, R. Zhang, L. Feng, G. Liu, H. Wu, A. K. Bindra, D. Jana, Z. Liu, Y. L. Zhao, A hypoxia-responsive albumin-based nanosystem for deep tumor penetration and excellent therapeutic efficacy. Adv. Mater. 2019, 31, 1901513. H. Chen, X. Zeng, H. P. Tham, S. Z. F. Phua, W. Cheng, W. Zeng, H. Shi, L. Mei, Y. L. Zhao, NIR-light-activated combination therapy with a precise ratio of photosensitizer and prodrug using a host-guest strategy. Angew. Chem. Int. Ed. 2019, 58, 7641-7646. S. Z. F. Phua, G. Yang, W. Q. Lim, A. Verma, H. Chen, T. Thanabalu, Y. L. Zhao, Catalase integrated hyaluronic acid as nanocarriers for enhanced photodynamic therapy in solid tumor. ACS Nano 2019, 13, 4742-4751. Z. Miao, G. Liu, Y. Cui, Z. Liu, J. Li, F. Han, Y. Liu, X. Sun, X. Gong, Y. Zhai, Y. L. Zhao, Y. Zeng, A novel strategy for construction of covalent organic frameworks from nonporous covalent organic polymers. Angew. Chem. Int. Ed. 2019, 58, 4906-4910. J. Huang, Y. Wang, X. Liu, Y. Li, X. Hu, B. He, Z. Shu, Z. Li, Y. L. Zhao, Synergistically enhanced charge separation in BiFeO3/Sn:TiO2 nanorod photoanode via bulk and surface dual modifications. Nano Energy 2019, 59, 33-40. G. Yang, S. Z. F. Phua, A. K. Bindra, Y. L. Zhao, Degradability and clearance of inorganic nanoparticles for biomedical applications. Adv. Mater. 2019, 31, 1805730. H. Wu, W. Chi, Z. Chen, G. Liu, L. Gu, A. K. Bindra, G. Yang, X. Liu, Y. L. Zhao, Achieving amorphous ultralong room temperature phosphorescence by coassembling planar small organic molecules with polyvinyl alcohol. Adv. Funct. Mater. 2019, 29, 1807243. P. Z. Li, X. J. Wang, Y. L. Zhao, Click chemistry as a versatile reaction for construction and modification of metal-organic frameworks. Coord. Chem. Rev. 2019, 380, 484-518.

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