个人简介

B.Sc., National University of Singapore; Ph.D., University of Melbourne, Post-doc: Belgium

研究领域

Single-Molecule Detection/Materials Chemistry/Polymer Physics/Photo-induced Molecular Devices

Research Interest Introduction The Single-Molecule and Applied Spectroscopy Laboratory is interested in understanding fundamental and important processes occurring in Materials Chemistry, Polymer Physics, Nanotechnology and Biological Chemistry at the single-molecule level. We use single-molecule detection and applied spectroscopy techniques in our research and are constantly developing new techniques with greater sensitivity. (a) Materials Chemistry and Polymer Physics The effects of confinement on the properties of thin polymeric films are of great importance. However, the nature of such effects remains relatively unknown. Single-(macro)-molecule tracking via wide-field fluorescence microscopy is used to study fundamental physical processes such as the crystallization of ultrathin layers of single polymeric chains. A better insight into the effects of confinement and substrate-polymer interaction is obtained by visualizing these processes in real-time. Wide-field microscopy images of a poly(ethylene oxide) sample maintained at 45oC for (a) 35 h, (b) 47 h, and (c) > 65 h. (b) Biological Chemistry In collaboration with Dr. Bengang Xing (CBC), we will tackle the problem of bacterial resistance against antibiotics. Single-molecule detection techniques such as wide-field microscopy and fluorescence correlation spectroscopy will be employed. This study will have important implications in drug design. (c) Nanotechnology and Light-Induced Molecular Devices We are interested in understanding the driving force behind light-induced molecular devices at the single-molecule level. In particular, a pertinent question that the group wishes to address is the driving force behind the charge-recombination process found in solar cells. Electron transport of the injected electron on TiO2 nanoparticle after its transfer from single Atto647N dye molecules encapsulated in cucurbit[7]uril gives rise to long-lived dark charge-separated states that are directly probed using the fluorescence intermittency of the emission intensity trajectories.

近期论文

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Wu, X.; Liu, F.; Wells, K.L.; Tan, S.L.J.; Webster, R.D.; Tan, H.-S.; Zhang, D.; Xing, B.; Yeow, E. K.L.; “Interplay of Hole Transfer and Host-Guest Interaction in Molecular Dyad and Triad: Ensemble and Single-Molecule Spectroscopy and Sensing Applications”, Chem. Eur. J. 2015, 21, 3387. [Abstract] Wu, W.-Y.; Li, M.; Wu, X.; Yeow, E.K.L.; Jhon, M.H.; Chan, Y.; “Efficient Color-Tunable Multiexcitonic Dual Wavelength Emission from Type II Semiconductor Tetrapods”, ACS Nano 2014, 8, 9349. [Abstract] Teguh, J.S.; Sum, T.C.; Yeow, E.K.L.; “Effect of Charge Accumulation on the Stability of PEDOT:PSS During Device Operation”, Chem. Phys. Lett. 2014, 607, 52. [Abstract] Solanki, A.; Wu, B.; Salim, T.; Yeow, E.K.L.; Lam, Y.M.; Sum, T.C.; “Performance Improvements in Polymer Nanofiber/Fullerene Solar Cells with External Field Treatment”, J. Phys. Chem. C 2014, 118, 11285. [Abstract] Xu, B.; Wu, X.; Yeow, E.K.L.; Shao, F.; “Single Thiazole Orange Forms Exciplex in DNA i-Motif”, Chem. Commun. 2014, 50, 6402. [Abstract] Liu, F; Mu, J.; Wu, X.; Bhattacharjya, S.; Yeow, E.K.L.; Xing, B.; “Peptide-Perylene Diimide Functionalized Magnetic Nano-Platforms for Fluorescence Turn-On Detection and Clearance of Bacterial Lipopolysaccharide”, Chem. Commun. 2014, 50, 6200. [Abstract] Li, J.; Liu, F.; Shao, Q.; Min, Y.; Costa, M.; Yeow, E.K.L.; Xing, B.; “Enzyme-Responsive Cell-Penetrating Peptides Conjugated Mesoporous Silica Quantum Dots Nanocarriers for Controlled Release of Nucleus-Targeted Drug Molecules and Real-Time Intracellular Fluorescence Imaging of Tumor Cells”, Adv. Healthcare Mater. 2014, 3, 1230. [Abstract] Sun, L.; Hu, H.; Zhan, D.; Yan, J.; Liu, L.; Teguh, J.S.; Yeow, E.K.L.; Lee, P.S.; Shen, Z.; “Plasma Modified MoS2 Nanoflakes for Surface Enhanced Raman Scattering”, Small 2014, 10, 1090. [Abstract] Min, Y.; Li, J.; Liu, F.; Padmanabhan, P.; Yeow, E.K.L.; Xing, B.; “Recent Advances of Biological Molecular Imaging Based on Lanthanide-Doped Upconversion-Luminescence Nanomaterials”, Nanomaterials 2014, 4, 129. [Abstract] Yu, G.; Liu, X.; Xing, G.; Chen, S.; Ng, F.N.; Wu, X.; Yeow, E.K.L.; Lew, W.X.; Sum, T.C.; “Spatially-Resolved Ultrafast Optical Spectroscopy of Polymer-Grafted Residues on CVD Graphene”, J. Phys. Chem. C 2014, 118, 708. [Abstract] Min, Y.; Li, J.; Liu, F.; Yeow, E.K.L.; Xing, B.; “Near-Infrared Light Mediated Photoactivation of Platinum Antitumor Prodrug and Simultaneous Cellular Apoptosis Imaging via Upconversion Nanoparticles”, Angew. Chem. Int. Ed. 2014, 53, 1016. [Abstract] Peimyoo, N.; Shang, J.; Cong, C.; Shen, X.; Wu, X.; Yeow, E.K.L.; Yu, T.; “Non-Blinking Intense Two-Dimensional Light Emitter: Monlayer WS2 Triangle”, ACS Nano 2013, 7, 10985. [Abstract] Lu, S.; Bi, W.; Liu, F.; Wu, X.; Xing, B.; Yeow, E.K.L.; “Loss of Collective Motion in Swarming Bacteria Undergoing Stress”, Phys. Rev. Lett. 2013, 111, 208101. [Abstract] Wu, B.; Wu, X.; Guan, C.; Tai, K.F.; Yeow, E.K.L.; Fan, H.J.; Mathews, N.; Sum, T.C.; “The Loss Mechanisms in Silver Nanoparticle-Blended Plasmonic Organic Solar Cells”, Nat. Commun. 2013, 4, 2004. [Abstract] Liu, J.; Yang, H.; Zhen, S.G.; Poh, C.K.; Chaurasia, A.; Luo, J.; Wu, X.; Yeow, E.K.L.; Sahoo, N.G.; Lin, J.; Shen, Z., “A Green Approach to the Synthesis of High-Quality Graphene Oxide Flakes via Electrochemical Exfoliation of Pencil Core”, RSC Adv. 2013, 3, 11745-11750. [Abstract] Teguh, J.S.; Kurniawan, M.; Wu, X.; Sum, T.C.; Yeow, E.K.L., “Other Origins for the Fluorescence Modulation of Single Dye Molecules in Open-Circuit and Short-Circuit Devices”, Phys. Chem. Chem. Phys. 2013, 50, 90-93. [Abstract] Xing, G.; Liao, Y.; Wu, X.; Chakrabortty, S.; Liu, X.; Yeow, E.K.L.; Chan, Y.; Sum, T.C., “Ultralow Threshold Two-Photon Pumped Amplified Spontaneous and Lasing from Seeded CdSe/CdS Nanorod Heterostructures”, ACS Nano 2012, 6, 10835-10844. [Abstract] Kurniawan, M.; Salim, T.; Tai, K.F.; Sun, S.; Sie, E.J.; Wu, X.; Yeow, E.K.L.; Huan, A.C.H.; Lam, Y.M.; Sum, T.C., “Carrier Dynamics in Polymer-Nanofiber: Fullerene Solar Cells”, J. Phys. Chem. C 2012, 116, 18015-18022. [Abstract] Bi, W.; Wu, X.; Yeow, E.K.L., “Unconventional Multiple Ring Structure Formation from Evaporation-Induced Self-Assembly of Polymers”, Langmuir 2012, 28, 11056-11063. [Abstract] Wu, B.; Oo, T. Z.; Li, X.; Liu, X.; Wu, X.; Yeow, E.K.L.; Fan, H.J.; Mathews, N.; Sum, T.C., “Efficiency Enhancement in Bulk-Heterojunction Solar Cells Integrated with Large Area Ag Nano-Triangle Arrays”, J. Phys. Chem. C 2012, 116, 14820-14825. [Abstract]