Wiese, Martin - University of Strathclyde - Strathclyde Institute of Pharmacy & Biomedical Sciences

个人简介

I joined the University in 2007 and I’m currently a John Anderson Research Senior Lecturer in Molecular Parasitology and Biochemistry.

研究领域

My research focuses on Leishmania protein kinases as potential drug targets and as important regulators for flagellum maintenance. Leishmania is a protozoan parasite that can cause death in infected humans and animals. Protein kinases have been shown to be essential for survival of this parasite in the infected host. Hence, specific inhibitors for parasite protein kinases have the potential to be ideal drugs to treat leishmaniasis. On the other hand Leishmania has a single flagellum containing structures conserved in all organisms forming cilia or flagella including humans. Understanding how flagellum formation and maintenance is regulated in Leishmania will help to understand and cure human disorders affecting the function of cilia and flagella. I am using phosphoproteomics, molecular parasitology and protein biochemistry to identify relevant protein kinases, their activators and substrates. This will allow me to develop enzyme assays to screen for inhibitors of the target protein kinases, which can be developed into useful medicines.

近期论文

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An arginine deprivation response pathway is induced in Leishmania during macrophage invasionGoldman-Pinkovich Adele, Balno Caitlin, Strasser Rona, Zeituni-Molad Michal, Bendelak Keren, Rentsch Doris, Ephros Moshe, Wiese Martin, Jardim Armando, Myler Peter J, Zilberstein DanPLOS Pathogens Vol 12, (2016)http://dx.doi.org/10.1371/journal.ppat.1005494 Transgenic analysis of the Leishmania MAP kinase MPK10 reveals an auto-inhibitory mechanism crucial for stage-regulated activity and parasite viabilityCayla Mathieu, Rachidi Najma, Leclercq Olivier, Schmidt-Arras Dirk, Rosenqvist Heidi, Wiese Martin, Sp?th Gerald FPLOS Pathogens Vol 10, (2014)http://dx.doi.org/10.1371/journal.ppat.1004347 The Leishmania donovani chaperone cyclophilin 40 is essential for intracellular infection independent of its stage-specific phosphorylation statusYau Wai-Lok, Pescher Pascale, MacDonald Andrea, Hem Sonia, Zander Dorothea, Retzlaff Silke, Blisnick Thierry, Rotureau Brice, Rosenqvist Heidi, Wiese Martin, Bastin Philippe, Clos Joachim, Sp?th GeraldMolecular Microbiology Vol 93, pp. 80–97, (2014)http://dx.doi.org/10.1111/mmi.12639 Modulation of Leishmania major aquaglyceroporin activity by a mitogen-activated protein kinaseMandal Goutam, Sharma Mansi, Kruse Martin, Sander-Juelch Claudia, Munro Laura A, Wang Yong, Vilg Jenny Veide, Tamás Markus J, Bhattacharjee Hiranmoy, Wiese Martin, Mukhopadhyay RitaMolecular Microbiology Vol 85, pp. 1204–1218, (2012)http://dx.doi.org/10.1111/j.1365-2958.2012.08169.x The efficacy of aerosol treatment with non-ionic surfactant vesicles containing amphotericin B in rodent models of leishmaniasis and pulmonary aspergillosis infectionAlsaadi Manal, Italia Jagdishbhai Laxmanbhai, Mullen Alexander, Kumar M.N.V Ravi, Candlish A.A., Williams Roderick, Shaw C.D., Al-Gawhari Fatima, Coombs Graham, Wiese Martin, Thomson Alison, Puig-Sellart M., Wallace J., Sharp A, Wheeler Lee, Warn Peter, Carter KatharineJournal of Controlled Release Vol 160, pp. 685-691, (2012)http://dx.doi.org/10.1016/j.jconrel.2012.04.004 LmxMPK4, an essential mitogen-activated protein kinase of Leishmania mexicana is phosphorylated and activated by the STE7-like protein kinase LmxMKK5von Freyend Simona John, Rosenqvist Heidi, Fink Annette, Melzer Inga Maria, Clos Joachim, Jensen Ole N?rregaard, Wiese MartinInternational Journal for Parasitology Vol 40, pp. 969-978, (2010)http://dx.doi.org/10.1016/j.ijpara.2010.02.004