个人简介

B.S., Boston College, 1967; Ph.D., Yale University, 1972; D.Sc.h.c., Boston College. Assistant Professor, Caltech, 1973-79; Associate Professor, 1979-82; Professor, 1982-88; Bren Professor, 1988-. Chair, Division of Chemistry and Chemical Engineering, 1994-99; Vice President for Development and Institute Relations, 2011-12.

研究领域

Organic, Physical Organic, Bioorganic, and Materials Chemistry Assistant: Victoria Brennan Professor Dervan's research program addresses a wide range of fundamental problems at the interface of organic chemistry and biology. Elucidating the chemical principles for the molecular recognition of DNA by small molecules and their use in biology, in particular gene modulation and DNA detection, are unifying themes.

Biochemistry and Molecular Biophysics; Chemistry

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Tumor Xenograft Uptake of a Pyrrole-Imidazole (Py-Im) Polyamide Varies as a Function of Cell Line Grafted, Jevgenij A. Raskatov, Jerzy O. Szablowski, Peter B. Dervan. J. Med. Chem., 57, 8471-8476, (2014). Replication stress by Py-Im polyamides induces a non-canonical ATR-dependent checkpoint response, Thomas F. Martinez, John W. Phillips, Kenneth K. Karanja, Piotr Polaczek, Chieh-Mei Wang, Benjamin C. Li, Judith L. Campbell, Peter B. Dervan. Nucleic Acids Res., 42, 11546-11559, (2014). A C-14 Labeled Py-Im Polyamide Localizes to a Subcutaneous Prostate Cancer Tumor., Jevgenij A. Raskatov, James W. Puckett, Peter B. Dervan. Bioorg. Med. Chem., 22, 4371-4375, (2014). Design of a Hairpin Py-Im Polyamide for DNA Methyltransferase Inhibition, JeenJoo S. Kang, Jordan L. Meier, Peter B. Dervan. J. Am. Chem. Soc., 136, 3687-3694, (2014). Animal Toxicity of Hairpin Pyrrole-Imidazole Polyamides Varies with the Turn Unit, Fei Yang, Nicholas G. Nickols, Benjamin C. Li, Jerzy O. Szablowski, Shari R. Hamilton, Jordan L. Meier, Chieh-Mei Wang, Peter B. Dervan. J. Med. Chem., 56, 7449-7457, (2013). Activity of a Py-Im Polyamide Targeted to the Estrogen response Element, Nicholas G. Nickols, Jerzy O. Szablowski, Amanda E. Hargrove, Benjamin C. Li, Jevgenij A. Raskatov, Peter B. Dervan. Mol. Cancer Ther., 12, 675-684, (2013). Molecular basis of anitibiotic multiresistance transfer in Staphylococcus aureus, Jonathan S. Edwards, Laurie Betts, Monica L. Frazier, Rebecca M. Pollet, Stephen M. Kwong, William G. Walton, W. Keith Ballentine III, Juianne J. Huang, Sohrab Habibi, Mark Del Campo, Jordan L. Meier, Peter B. Dervan, Neville Firth, Matthew R. Redinbo. Proc. Natl. Acad. Sci. USA, 110, 2804-2809, (2013). Antitumor Activity of a Pyrrole-imidazole Polyamide, Fei Yang, Nicholas G. Nickols, Benjamin C. Li, Georgi K. Marinov, Jonathan W. Said, Peter B. Dervan. Proc. Natl. Acad. Sci. USA, 110, 1863-1868, (2013). Synthesis of Cyclic Py-Im Polyamide Libraries, Benjamin C. Li, David C. Montgomery, James W. Puckett, Peter B. Dervan. J. Org. Chem, 78, 124-133, (2013). Pyrrole-Imidazole Polyamides Distinguish Between Double-Helical DNA and RNA, David M. Chenoweth, Jordan L. Meier, Peter B. Dervan. Angew. Chem. Int. Ed, 52, 415-418, (2013). Guiding the Design of Synthetic DNA-Binding Molecules with Massively Parallel Sequencing, Jordan L. Meier, Abigail S. Yu, Ian Korf, David J. Segal, Peter B. Dervan. J. Am. Chem. Soc., 134, 17814-17822, (2012). Gene expression changes in a tumor xenograft by a pyrrole-imidazole polyamide, Jevgenij A. Raskatov, Nicholas G. Nickols, Amanda E. Hargrove, Georgi K. Marinov, Barbara Wold, Peter B. Dervan. Proc. Natl. Acad. Sci. USA, 109, 16041-16045, (2012). Single-dose pharmacokinetic and toxicity analysis of pyrrole–imidazole polyamides in mice, Timothy W. Synold, Bixin Xi, Jun Wu, Yun Yen, Benjamin C. Li, Fei Yang, John W. Phillips, Nicholas G. Nickols, Peter B. Dervan. Cancer Chemoth. Pharm., 70, 617-625, (2012). Role of mismatch repair enzymes in GAA•TTC triplet-repeat expansion in Friedreich’s ataxia induced pluripotent stem cells, Jintang Du, Erica Campau, Elisabetta Soragni, Sherman Ku, James W. Puckett, Peter B. Dervan, Joel M. Gottesfeld. J. Biol. Chem., 287, 29861–29872, (2012). Characterization and solubilization of pyrrole-imidazole polyamide aggregates, Amanda E. Hargrove, Jevgenij A. Raskatov, Jordan L. Meier, David C. Montgomery, Peter B Dervan. J. Med. Chem., 55, 5425–5432, (2012). Microwave Assisted Synthesis of Py-Im Polyamides, James W. Puckett, Joshua T. Green, Peter B. Dervan. Org. Lett, 14, 2774-2777, (2012). Pharmacokinetics of Py-Im Polyamides Depend on Architecture: Cyclic versus Linear, Jevgenij A. Raskatov, Amanda E. Hargrove, Alex Y. So, Peter B. Dervan. J. Am. Chem. Soc., 134, 7995–7999, (2012). Chromatin structure determines accessibility of a hairpin polyamide-chlorambucil conjugate at histone H4 genes in pancreatic cancer cells, Christine Jespersen, Elisabetta Soragni, C. James Chou, Paramjit S. Arora, Peter B. Dervan, Joel M. Gottesfeld. Bioorg. Med. Chem. Lett., 22, 4068–4071, (2012). Modulation of NF-kappaB-dependent gene transcription using programmable DNA minor groove binders, Jevgenij A. Raskatov, Jordan L. Meier, James W. Puckett, Fei Yang, Parameswaran Ramakrishnan, Peter B. Dervan. Proc. Natl. Acad. Sci. USA, 109, 1023–1028, (2012). Enhancing the Cellular Uptake of Py-Im Polyamides through Next-Generation Aryl Turns, Jordan L. Meier, David C. Montgomery, Peter B. Dervan. Nucleic Acids Res, 40, 2345-2356, (2012).