Steendam, Rene - University of Strathclyde - Strathclyde Institute of Pharmacy & Biomedical Sciences

个人简介

René studied organic chemistry at the Radboud University in Nijmegen (the Netherlands). His PhD research took place at the same university and his topic involved merging organic synthesis with solid-state deracemization of chiral molecules. He joined the group of Prof. ter Horst at CMAC in 2015 to develop a platform which allows the continuous synthesis and deracemization of chiral crystals. With this new approach, he also aims to find out more about the driving mechanism behind solid-state deracemization.

近期论文

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One-pot synthesis, crystallization and deracemization of isoindolinones from achiral reactantsSteendam René R E, Kulka Micha?l W., Meekes Hugo, Van Enckevort Willem J P, Raap Jan, Vlieg Elias, Rutjes Floris P J TEuropean Journal of Organic Chemistry Vol 2015, pp. 7249-7252, (2015)http://dx.doi.org/10.1002/ejoc.201501191 Viedma ripening : a reliable crystallisation method to reach single chiralityS?gütoglu Leyla-Cann, Steendam René R. E., Meekes Hugo, Vlieg Elias, Rutjes Floris P. J. T.Chemical Society Reviews Vol 44, pp. 6723-6732, (2015)http://dx.doi.org/10.1039/c5cs00196j Deracemization controlled by reaction-induced nucleation : viedma ripening as a safety catch for total spontaneous resolutionSteendam René R. E., van Benthem Tim J. B., Huijs Evelien M. E., Meekes Hugo, van Enckevort Willem J. P., Raap Jan, Rutjes Floris P. J. T., Vlieg EliasCrystal Growth and Design Vol 15, pp. 3917-3921, (2015)http://dx.doi.org/10.1021/acs.cgd.5b00531 Linear deracemization kinetics during Viedma ripening : autocatalysis overruled by chiral additivesSteendam René R E, Dickhout Janneke, Van Enckevort Willem J P, Meekes Hugo, Raap Jan, Rutjes Floris P J T, Vlieg EliasCrystal Growth and Design Vol 15, pp. 1975-1982, (2015)http://dx.doi.org/10.1021/acs.cgd.5b00127 Emergence of single-molecular chirality from achiral reactantsSteendam René R E, Verkade Jorge M M, van Benthem Tim J B, Meekes Hugo, van Enckevort Willem J P, Raap Jan, Rutjes Floris P J T, Vlieg EliasNature Communications Vol 5, pp. 5543, (2014)http://dx.doi.org/10.1038/ncomms6543 Enantiopure isoindolinones through Viedma ripeningSteendam René R. E., Brouwer Maxime C. T., Huijs Evelien M. E., Kulka Micha?l W., Meekes Hugo, van Enckevort Willem J. P., Raap Jan, Rutjes Floris P. J. T., Vlieg EliasChemistry - A European Journal Vol 20, pp. 13527-13530, (2014)http://dx.doi.org/10.1002/chem.201404320