Rotondo, D - University of Strathclyde - Strathclyde Institute of Pharmacy & Biomedical Sciences

研究领域

research interests have centred on the pivotal role that monocytes play in coordinating immune responses by releasing cytokines, prostaglandins and fatty acids. The cytokines released from monocytes, particularly interleukin-1 and tumour necrosis factor-alpha, can also amplify the antigen-induced activation of T-cells whereas prostaglandins such as PGE2 and fatty acids are potent inhibitors of activation. Recent data indicates that IL-1-stimulated fatty acid release can result in the biosynthesis of fatty acid ethanolamides including arachidonyl ethanolamide (anandamide) in addition to eicosanoids. Arachidonyl ethanolamide, regarded as an endogenous ligand for cannabinoid receptors, has been shown in our studies to modulate the activity of many monocyte and lymphocyte functions. Several major areas are being studied, including modulation of human monocyte and T-lymphocyte activities by PGE2, fatty acids and fatty acid ethanolamides. Current work has been directed toward an attempt to understand the mechanisms by which PGE2 and fatty acids regulate: cytokine production, phagocytosis of E. coli O157 in human monocytes and the downregulation of human CD4+ lymphocyte function, especially via the generation of intracellular cyclic AMP and cyclic GMP. The role of novel steroids, acting via PGs, on the modulation of immune cell activities is also being investigated as these provide another important potential therapeutic target

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Regulation of lipid metabolism by microRNAsTate Rothwelle, Rotondo Dino, Davidson JillianCurrent Opinion in Lipidology Vol 26, pp. 243-244, (2015)http://dx.doi.org/10.1097/MOL.0000000000000186 Blood immunoglobulins, complement and TNF receptor following minimally invasive surgery in patients undergoing pulmonary lobectomyLeaver H. Anne, Craig Stewart R., Rotondo Dino, Walker William S.Current Metabolomics Vol 2, pp. 196-203, (2015)http://dx.doi.org/10.2174/2213235X03666150106232345 Genetics and molecular biology : the role of retinoic acid receptor genes in acute promyelocytic leukemiaDavidson Jillian, Tate Rothwelle, Rotondo DinoCurrent Opinion in Lipidology Vol 24, pp. 364-365, (2013)http://dx.doi.org/10.1097/MOL.0b013e328363b199 Eicosapentaenoic acid suppression of systemic inflammatory responses and inverse up-regulation of 15-deoxy Δ12,14 Prostaglandin J2 productionDavidson Jillian, Higgs Warren, Rotondo DBritish Journal of Pharmacology Vol 169, pp. 1130-1139, (2013)http://dx.doi.org/10.1111/bph.12209 Characterisation of the prostaglandin E2-ethanolamide suppression of tumour necrosis factor-α production in human monocytic cellsBrown Kirsten L., Davidson Jillian, Rotondo DBiochimica et Biophysica Acta Molecular and Cell Biology of Lipids Vol 1831, pp. 1098–1107, (2013)http://dx.doi.org/10.1016/j.bbalip.2013.03.006 Cannabinoids and omega-3/6 endocannabinoids as cell death and anticancer modulatorsBrown Iain, Cascio Maria G., Rotondo D, Pertwee Roger G., Heys Steven D., Wahle Klaus W.J.Progress in Lipid Research Vol 52, pp. 80-109, (2013)http://dx.doi.org/10.1016/j.plipres.2012.10.001