Pyne, Susan - University of Strathclyde - Strathclyde Institute of Pharmacy & Biomedical Sciences

个人简介

1993-2001 Wellcome Trust Senior Research Fellow 2014 Laurens van Deenen Lecture (awarded by ICBL for out-standing and long-term contributions to lipid research)

研究领域

Sphingosine 1-phosphate signalling in health and disease - at a cellular level (cell division, migration, survival) in model cell lines; in vascular function (e.g. regulation of vascular tone, cardioprotection); in disease (e.g. cancer of the breast, prostate, colon etc.). Isoform diversity, regulation and spatial signalling involving sphingosine kinases Isoform diversity and regulation of lipid phosphate phosphatases

近期论文

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Sphingosine 1-phosphate receptor 1 signaling in mammalian cellsPyne Nigel J., Pyne SusanMolecules Vol 22, pp. 1-18, (2017)http://dx.doi.org/10.3390/molecules22030344 Effect of sphingosine kinase modulators on interleukin-1β release, sphingosine 1-phosphate receptor 1 expression and experimental autoimmune encephalomyelitis : FTY720 analogues and inflammationBarbour Mark, McNaughton Melissa, Boomkamp Stephanie D., MacRitchie Neil, Jiang Hui-Rong, Pyne Nigel J, Pyne SusanBritish Journal of Pharmacology Vol 174, pp. 210-222, (2017)http://dx.doi.org/10.1111/bph.13670 Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignanciesEvangelisti C, Evangelisti C, Buontempo F, Lonetti A, Orsini E, Chiarini F, Barata J T, Pyne S, Pyne N J, Martelli A MLeukemia Vol 30, pp. 2142–2151, (2016)http://dx.doi.org/10.1038/leu.2016.208 Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodeling in a hypoxic model of pulmonary arterial hypertensionMacRitchie Neil, Volpert Giora, Al Washih Mohammed, Watson David G., Futerman Anthony H., Kennedy Simon, Pyne Susan, Pyne NigelCellular Signalling Vol 28, pp. 946-955, (2016)http://dx.doi.org/10.1016/j.cellsig.2016.03.014 Sphingosine kinases : emerging structure function insightsAdams David R., Pyne Susan, Pyne Nigel J.Trends in Biochemical Sciences Vol 41, pp. 395-409, (2016)http://dx.doi.org/10.1016/j.tibs.2016.02.007 Sphingosine 1-phosphate and sphingosine kinases in health and disease : recent advancesPyne Susan, Adams David R, Pyne Nigel J.Progress in Lipid Research Vol 62, pp. 93-106, (2016)http://dx.doi.org/10.1016/j.plipres.2016.03.001