Pyne, Nigel - University of Strathclyde - Strathclyde Institute of Pharmacy & Biomedical Sciences

个人简介

1995 Sandoz Prize in Pharmacology (awarded by the British Pharmacological Society) 2010 Elected Member of Academy of Sciences of the Institute of Bologna (affilated with the University of Bologna, founded in 1690)

研究领域

Lysolipid (sphingosine 1-phosphate, lysophoshatidic acid) receptor signalling in health and disease with specific focus on cancer and cardiovascular/inflammatory disease Cross talk regulation between lysolipid receptors and growth factor receptors/oncogenes (e.g. PDGFR, HER2, EGFR and TRK A) Translational biology of lysolipids (e.g. drug discovery and biomarker identification) Cyclic AMP/cyclic GMP signalling

近期论文

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Sphingosine 1-phosphate receptor 1 signaling in mammalian cellsPyne Nigel J., Pyne SusanMolecules Vol 22, pp. 1-18, (2017)http://dx.doi.org/10.3390/molecules22030344 Effect of sphingosine kinase modulators on interleukin-1β release, sphingosine 1-phosphate receptor 1 expression and experimental autoimmune encephalomyelitis : FTY720 analogues and inflammationBarbour Mark, McNaughton Melissa, Boomkamp Stephanie D., MacRitchie Neil, Jiang Hui-Rong, Pyne Nigel J, Pyne SusanBritish Journal of Pharmacology Vol 174, pp. 210-222, (2017)http://dx.doi.org/10.1111/bph.13670 Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignanciesEvangelisti C, Evangelisti C, Buontempo F, Lonetti A, Orsini E, Chiarini F, Barata J T, Pyne S, Pyne N J, Martelli A MLeukemia Vol 30, pp. 2142–2151, (2016)http://dx.doi.org/10.1038/leu.2016.208 Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodeling in a hypoxic model of pulmonary arterial hypertensionMacRitchie Neil, Volpert Giora, Al Washih Mohammed, Watson David G., Futerman Anthony H., Kennedy Simon, Pyne Susan, Pyne NigelCellular Signalling Vol 28, pp. 946-955, (2016)http://dx.doi.org/10.1016/j.cellsig.2016.03.014 Sphingosine kinases : emerging structure function insightsAdams David R., Pyne Susan, Pyne Nigel J.Trends in Biochemical Sciences Vol 41, pp. 395-409, (2016)http://dx.doi.org/10.1016/j.tibs.2016.02.007 Sphingosine 1-phosphate and sphingosine kinases in health and disease : recent advancesPyne Susan, Adams David R, Pyne Nigel J.Progress in Lipid Research Vol 62, pp. 93-106, (2016)http://dx.doi.org/10.1016/j.plipres.2016.03.001