Plevin, Robin - University of Strathclyde - Strathclyde Institute of Pharmacy & Biomedical Sciences

个人简介

Robin Plevin, Professor in Pharmacology (2002). BSc (Hons), University of Edinburgh (1983), PhD, University of Southampton (1987). The Plevin laboratory is hard working but friendly, housing researchers from many countries around the world. The laboratory studies aspects of signalling in relation to inflammation, vascular disease and cancer. The lab has strong collaborations both internally, nationally and internationally. A strong emphasis on career development is one of the features of this laboratory.

研究领域

MAP kinase phosphatase-2 in cellular function. We have recently generated a novel MKP-2 (DUSP-4) KO mouse and are currently assessing outcomes in cancer, inflammatory disease and immunity. We have recently identified a novel role for this gene during leishmania infection and in controlling the cell cycle. Protease-activated receptors- signalling and inflammation. We are investigating the role of this novel class of GPCR within the immune system and correlating this with effects upon intracellular signalling and trafficking. Cell signalling responses to Leishmania. We are currently studying the intracellular signalling effects of Leishmania mexicana in relation to infection. Natural products as inhibitors of NFκB signalling - implications for inflammatory disease and cancer. We are sudying the effects of defined natural products as inhibitors of intracellular signalling pathways, in particular the NFκB cascade, for use in vascular disease, arthritis and cancer

近期论文

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MAP kinase phosphatase 2 deficient mice develop attenuated experimental autoimmune encephalomyelitis through regulating dendritic cells and T cellsBarbour Mark, Plevin Robin, Jiang Hui-RongScientific Reports Vol 6, pp. 1-13, (2016)http://dx.doi.org/10.1038/srep38999 Proteinase-activated receptors (PARs) as targets for antiplatelet therapyCunningham Margaret, McIntosh Kathryn, Bushell Trevor, Sloan Graeme, Plevin RobinBiochemical Society Transactions Vol 44, pp. 606-612, (2016)http://dx.doi.org/10.1042/BST20150282 Mitogen-activated protein kinase phosphatase-2 deletion impairs synaptic plasticity and hippocampal-dependent memoryAbdul Rahman Nor Zaihana Binti, Greenwood Sam M., Brett Ros R., Tossell Kyoko, Ungless Mark A., Plevin Robin, Bushell Trevor J.Journal of Neuroscience Vol 36, pp. 2348-2354, (2016)http://dx.doi.org/10.1523/JNEUROSCI.3825-15.2016 Protease-activated receptor 2 : are common functions in glial and immune cells linked to inflammation-related CNS disorders?Bushell Trevor J., Cunningham Margaret R., McIntosh Kathryn A., Moudio Serge, Plevin RobinCurrent Drug Targets Vol 17, pp. 1861-1870, (2016)http://dx.doi.org/10.2174/1389450117666151209115232 Proteinase-activated receptor 2 modulates OA-related pain, cartilage and bone pathologyHuesa Carmen, Ortiz Ana C, Dunning Lynette, McGavin Laura, Bennett Louise, McIntosh Kathryn, Crilly Anne, Kurowska-Stolarska Mariola, Plevin Robin, van ,t Hof Rob J, Rowan Andrew D, McInnes Iain B, Goodyear Carl S, Lockhart John C, Ferrell William RAnnals of the Rheumatic Diseases, (2015)http://dx.doi.org/10.1136/annrheumdis-2015-208268 MAP kinase phosphatase-2 plays a key role in the control of infection with Toxoplasma gondii by modulating iNOS and arginase-1 activities in miceWoods Stuart, Schroeder Juliane, McGachy Helen A, Plevin Robin, Roberts Craig W, Alexander JamesPLOS Pathogens Vol 9, (2013)http://dx.doi.org/10.1371/journal.ppat.1003535