Herron, Paul - University of Strathclyde - Strathclyde Institute of Pharmacy & Biomedical Sciences

个人简介

Paul Herron is a Senior Lecturer in Microbiology. He graduated from Liverpool Polytechnic before carrying put a PhD in Microbiology at the University of Warwick. After two years at the Agricultural University Wageningen he moved to the University of Wales Swansea where he developed transposon tools for mutagenesis of streptomycetes.

研究领域

Chromosome segregation in Streptomyces. cell division in streptomycetes is fundamentally different from other bacteria as it is inessential for growth. Despite progress on elucidating the regulatory mechanisms governing the onset of differentiation in streptomycetes, little is known about the mechanism of chromosome segregation. We are using molecular and microscopic tools to investigate this in Streptomyces. Using time lapse microscopy we have visualised trafficking of key cell division proteins and DNA replisomesduring growth and development.The role of Phospholipids in streptomycete development. The involvement of phospholipids in bacterial cell division has recently received increasing attention. Although different phospholipids are abundant in the membranes of Streptomyces, their involvement in development is not known. We are investigating changes in phospholipid profile and gene expression during differentiation. Oxytetracycline productivity in Streptomyces rimosus. In the commercial production of antibiotics, extensive strain improvement programs have been carried out, where the original isolate of an antibiotic-producing organism has been improved sequentially to deliver a titre of product that is commercially-viable. This "black box" methodology was carried out for Streptomyces rimosus, which makes the antibiotic oxytetracycline. To identify the basis of strain improvement we have sequenced the genomes of four S. rimosus strains and are attempting to understand the genetic changes and biochemical bottlenecks by which carbon flux is directed away from primary metabolism towards natural product biosynthesis. Exploitaion of Bacteriophages. In collaboration Fixed Phage Ltd. we are exploiting bacterial viruses for the treatment of plant and animal diseases

近期论文

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Unique function of the bacterial chromosome segregation machinery in apically growing streptomyces - targeting the chromosome to new hyphal tubes and its anchorage at the tipsKois-Ostrowska Agnieszka, Strza?ka Agnieszka, Lipietta Natalia, Tilley Emma, Zakrzewska-Czerwińska Jolanta, Herron Paul, Jakimowicz DagmaraPLOS Genetics Vol 12, (2016)http://dx.doi.org/10.1371/journal.pgen.1006488 Plasticity of streptomyces coelicolor membrane composition under different growth conditions and during developmentSandoval-Calderón Mario, Nguyen Don D., Kapono Clifford A., Herron Paul, Dorrestein Pieter C., Sohlenkamp ChristianFrontiers in Microbiology Vol 6, (2015)http://dx.doi.org/10.3389/fmicb.2015.01465 In vivo antimalarial activity of the endophytic actinobacteria, Streptomyces SUK 10Baba Mohd Shukri, Zin Noraziah Mohamad, Hassan Zainal Abidin Abu, Latip Jalifah, Pethick Florence, Hunter Iain S., Edrada-Ebel RuAngelie, Herron Paul R.Journal of Microbiology Vol 53, pp. 847-855, (2015)http://dx.doi.org/10.1007/s12275-015-5076-6 Construction of a new class of tetracycline lead structures with potent antibacterial activity through biosynthetic engineeringLe?nik Ur?ka, Luke?i? Tadeja, Podgor?ek Ajda, Horvat Jaka, Polak Toma?, ?ala Martin, Jenko Branko, Harmrolfs Kirsten, Ocampo-Sosa Alain, Martínez-Martínez Luis, Herron Paul R., Fujs ?tefan, Kosec Gregor, Hunter Iain S., Müller Rolf, Petkovi? HrvojeAngewandte Chemie Vol 54, pp. 3937-3940, (2015)http://dx.doi.org/10.1002/anie.201411028 Inactivation of Streptomyces phage ?C31 by 405 nm light : requirement for exogenous photosensitizers?Tomb Rachael M, MacLean Michelle, Herron Paul R, Hoskisson Paul A, MacGregor Scott J, Anderson John GBacteriophage Vol 4, (2014)http://dx.doi.org/10.4161/bact.32129 Identification of the chelocardin biosynthetic gene cluster from Amycolatopsis sulphurea : a platform for producing novel tetracycline antibioticsLuke?i? Tadeja, Le?nik Ur?ka, Podgor?ek Ajda, Horvat Jaka, Polak Toma?, ?ala Martin, Jenko Branko, Raspor Peter, Herron Paul R, Hunter Iain S, Petkovi? HrvojeMicrobiology Vol 159, pp. 2524-2532, (2013)http://dx.doi.org/10.1099/mic.0.070995-0