Harnett, William - University of Strathclyde - Strathclyde Institute of Pharmacy & Biomedical Sciences

个人简介

I joined the Department of Immunology at Strathclyde University as a lecturer in 1991 and was appointed Professor of Molecular Immunology in 2002. Immunology was one of five University departments, which merged to form Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS) in 2006. I acted as Director of Research in SIPBS from August 2009 until the end of 2013 and was previously Head of The immunology Department during the academic year, 2005-6.

研究领域

My research interests lie in elucidating the molecular mechanisms by which parasitic worms modulate the host immune system. A particular focus is on ES-62, an anti-inflammatory molecule secreted by the filarial nematode Acanthocheilonema viteae, which we are currently exploiting with a view to developing novel drugs for allergic and autoimmune diseases. This interest in immunology and parasitology also extends to my areas of teaching.

近期论文

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Parasite excretory-secretory products and their effects on metabolic syndromeCrowe Jenny, Lumb Felicity E., Harnett Margaret M., Harnett WilliamParasite Immunology, (2017)http://dx.doi.org/10.1111/pim.12410 The helminth product, ES-62 modulates dendritic cell responses by inducing the selective autophagolysosomal degradation of TLR-transducers, as exemplified by PKCδEason Russell J., Bell Kara S., Marshall Fraser A. , Rodgers David T., Pineda Miguel A., Steiger Christina N., Al-Riyami Lamyaa, Harnett William, Harnett Margaret M.Scientific Reports Vol 6, (2016)http://dx.doi.org/10.1038/srep37276 Testing small molecule analogues of acanthocheilonema viteae immunomodulator ES-62 against clinically relevant allergensJanicova L., Rzepecka J., Rodgers D.T., Doonan J., Bell K., Lumb F.E., Suckling C.J., Harnett M.M., Harnett W.Parasite Immunology Vol 38, pp. 340-351, (2016)http://dx.doi.org/10.1111/pim.12322 The carbohydrate-linked phosphorylcholine of the parasitic nematode product ES-62 modulates complement activationAhmed Umul Kulthum, Maller N. Claire, Iqbal Asif J., Al-Riyami Lamyaa, Harnett William, Raynes John G.Journal of Biological Chemistry Vol 291, pp. 11939-11953, (2016)http://dx.doi.org/10.1074/jbc.M115.702746 Brugia malayi Antigen (BmA) inhibits HIV-1 trans-infection but neither BmA nor ES-62 alter HIV-1 infectivity of DC induced CD4+ Th-cellsMouser Emily E. I. M., Pollakis Georgios, Yazdanbakhsh Maria, Harnett William, de Jong Esther C., Paxton William A.PLOS1 Vol 11, (2016)http://dx.doi.org/10.1371/journal.pone.014652 The parasitic worm-derived immunomodulator, ES-62 and its drug-like small molecule analogues exhibit therapeutic potential in a model of chronic asthmaColtherd J. C., Rodgers D. T., Lawrie R. E., Al-Riyami L., Suckling C. J., Harnett W., Harnett M. M.Scientific Reports Vol 6, (2016)http://dx.doi.org/10.1038/srep19224