Connolly, John - University of Strathclyde - Strathclyde Institute of Pharmacy & Biomedical Sciences

研究领域

Current research interests include the characterisation of antibodies which may be useful for the development of diagnostic tests for CJD, the amino acid determinants of the kinetics of antagonist interactions with nicotinic acetylcholine receptors, the interaction of alcohol with nicotinic acetylcholine receptors and the characterisation of novel pharmacological activities of plant extracts.

近期论文

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The tonic and toxic effects of alcohol and its metabolitesConnolly J.G.Pharmaceutical ChemistryPharmaceutical Chemistry, (2011) An antibody to the aggregated synthetic prion protein peptide (PrP106-126) selectively recognizes disease-associated prion protein (PrPSc) from human brain specimensJones Michael, Wight Darren, McLoughlin Victoria, Norrby Katherine, Ironside James W., Connolly John G., Farquhar Christine F., MacGregor Ian R., Head Mark W.Brain Pathology Vol 19, pp. 293-302, (2009)http://dx.doi.org/10.1111/j.1750-3639.2008.00181.x Production and characterisation of a panel of monoclonal antibodies against native human cellular prion proteinJones Michael, McLoughlin Victoria, Connolly J.G., Farquhar Christine F., MacGregor Ian R., Head Mark W.Hybridoma Vol 28, pp. 13-20, (2009)http://dx.doi.org/10.1089/hyb.2008.0067 The role of the amino acid residue at α1:189 in the binding of neuromuscular blocking agents to mouse and human muscle nicotinic acetylcholine receptorsGopal P., Tate R., Pow E., Hill D., Connolly J.G.British Journal of Pharmacology Vol 150, pp. 920-931, (2007)http://dx.doi.org/10.1038/sj.bjp.0707156 Purification of normal cellular prion protein from human platelets and the formation of a high molecular weight prion protein complex following platelet activationJones Michael, Head Mark W., Connolly John, Farquhar Christine F., Hornsey Valerie S., Pepper Duncan S., MacGregor Ian R.Biochemical and Biophysical Research Communications Vol 335, pp. 48-56, (2005)http://dx.doi.org/10.1016/j.bbrc.2005.07.045 Properties of the cellular prion protein expressed in Xenopus oocytesConnolly John G., Tate Roth J., McLennan Neil F., Brown Debbie, Telling Glenn C., Fraser Jan, Head Mark W.NeuroReport Vol 13, pp. 1229-1233, (2002)