个人简介

Education: B.Sc & M.Sc (Physics and Mathematics), M.V. Lomonosov Moscow State University; M.Sc. (Biophysics), University of Paris XI;

研究领域

Biophysics/Structure of DNA and RNA/Engineering of Nucleic Acids and Proteins

Research Interest My current research interests are to use a combination of physical, chemical and computational methods to investigate and manipulate properties of nucleic acids and proteins. My research goals include: Structures, dynamics, interactions and functions of DNA, RNA and proteins. Noncanonical structures of DNA and RNA as molecular targets against diseases. Structural design and engineering of nucleic acids and proteins. Application and development of methods, including Nuclear Magnetic Resonance (NMR) and other spectroscopic techniques, as well as single-molecule manipulations, for the study of biomolecular structures and dynamics. A research program focuses on the elucidation of non-canonical DNA structures formed by G-rich sequences in the telomeres and promoters of oncogenes. This project aims to provide a platform for structure-based anticancer drug design. Another research program involves the design of new structures of nucleic acids with desired biological properties. Structure of the complex formed between the drug TMPyP4 (magenta) and a DNA G-quadruplex in the c-MYC promoter (Phan et al., Nature Chem. Biol., 2005).

近期论文

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Chung W.J., Heddi B., Schmitt E., Lim K.W., Mechulam Y., Phan A.T. (2015). Structure of a left-handed G-quadruplex. Proc. Natl. Acad. Sci. USA, 112, 2729-2733. Lech C.J., Phan A.T., Michel-Beyerle M.E., Voityuk A.A. (2015). Influence of base stacking geometry on the nature of excited states in G-quadruplexes: A time-dependent DFT study. J. Phys. Chem. B, 119, 3697-3705. Lim K.W., Nguyen T.Q.N., Phan A.T. (2014). Joining of multiple duplex stems at a single quadruplex loop. J. Am. Chem. Soc., 136, 17969-17973. Sengar A., Heddi B., Phan A.T. (2014). Formation of G-quadruplexes in poly-G sequences: Structure of a propeller-type parallel-stranded G-quadruplex formed by a G15 stretch. Biochemistry, 53, 7718-7723. You H., Zeng X., Xu Y., Lim C.J., Efremov A.K., Phan A.T., Yan J. (2014). Dynamics and stability of polymorphic human telomeric G-quadruplex under tension. Nucleic Acids Res., 42, 8789-8795. Adrian M., Ang D.J., Lech C.J., Heddi B., Nicolas A., Phan A.T. (2014). Structure and conformational dynamics of a stacked dimeric G-quadruplex formed by the human CEB1 minisatellite. J. Am. Chem. Soc., 136, 6297-6305. Li Z., Lech C.J., Phan A.T. (2014). Sugar-modified G-quadruplexes: Effects of LNA-, 2'F-RNA- and 2'F-ANA guanosine chemistries on G-quadruplex structure and stability. Nucleic Acids Res., 42, 4068-4079. Martadinata H., Phan A.T. (2014). Formation of a stacked dimeric G-quadruplex containing bulges by the 5'-terminal region of human telomerase RNA (hTERC). Biochemistry, 53, 1595-1600. Lim K.W., Khong Z.J., Phan A.T. (2014). Thermal stability of DNA quadruplex-duplex hybrids. Biochemistry, 53, 247-257. Zhang L., Er J.C., Ghosh K.K., Chung W.J., Yoo J., Xu W., Zhao W., Phan A.T., Chang Y.T. (2014). Discovery of a structural-element specific G-quadruplex "light-up" probe. Sci. Rep., 4, 3776. Chung W.J., Heddi B., Hamon F., Teulade-Fichou M.P., Phan A.T. (2014). Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC3. Angew. Chem. Int. Ed., 53, 999-1002. Lim K.W., Ng V.C.M., Martin-Pintado N., Heddi B., Phan A.T. (2013). Structure of the human telomere in Na+ solution: an antiparallel (2+2) G-quadruplex scaffold reveals additional diversity. Nucleic Acids Res., 41, 10556-10562. Chung W.J., Heddi B., Tera M., Iida K., Nagasawa K., Phan A.T. (2013). Solution structure of an intramolecular (3+1) human telomeric G-quadruplex bound to a telomestatin derivative. J. Am. Chem. Soc., 135, 13495-13501. (Review in Faculty of 1000). Lim K.W., Phan A.T. (2013). Structural basis of DNA quadruplex-duplex junction formation. Angew. Chem. Int. Ed., 52, 8566-8569. (Review in Faculty of 1000). Cao C., Zhang J., Wen X., Dobson S.L., Dao N.T., Wong L.M., Wang S., Li S., Phan A.T., Xiong Q. (2013). Metamaterials-based label-free nanosensor for conformation and affinity biosensing. ACS Nano, 7, 7583-7591. Lech C.J., Phan A.T., Michel-Beyerle M.E., Voityuk A.A. (2013). Electron hole transfer in G-quadruplexes with different tetrad stacking geometries: A combined QM and MD study. J. Phys. Chem. B, 117, 9851-9856. Dao N.T., Haselsberger R., Michel-Beyerle M.E., Phan A.T. (2013). Excimer formation by stacking of G-quadruplex blocks. ChemPhysChem, 14, 2667-2671. Mukundan V.T, Phan A.T. (2013). Bulges in G-quadruplexes: Broadening the definition of G-quadruplex-forming sequences. J. Am. Chem. Soc., 135, 5017-5028. (Spotlight in Chem. Res. Toxicol., 2013 June 17, 26 (6), 839-840; Review in Faculty of 1000). Martadinata H., Phan A.T. (2013). Structure of human telomeric RNA (TERRA): Stacking of two G-quadruplex blocks in K+ solution. Biochemistry, 52, 2176-2183. Phan A.T., Do N.Q. (2013). Engineering of interlocked DNA G-quadruplexes as a robust scaffold. Nucleic Acids Res., 41, 2683-2688.