个人简介

B.S., University of Kentucky, 1977; M.S., 1978; Ph.D., 1981. Professor, Caltech, 1991-93; Schlinger Professor, 1993-. Executive Officer for Chemical Engineering, 1999-2004.

研究领域

Synthesis of zeolites and molecular sieves; Synthesis of catalytic materials; Synthesis of biomaterials; Gene therapy Assistant: Martha Hepworth The central theme of the Mark E. Davis research group is the use of chemical engineering concepts (synthetic chemistry and analytical engineering problem solving) to answer important fundamental questions in the physical and life sciences. Current research entails designs for the synthesis of inorganic and hybrid, organic-inorganic materials for catalysis and biocompatible materials for the delivery of macromolecular therapeutics.

Chemical Engineering

近期论文

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R. Bermejo-Deval, R. Gounder and M. E. Davis, "Framework and Extra Framework Tin Sites in Zeolite Beta React Glucose Differently," ACS Catal. 2, 2705 (2012). M. E. Davis, "Fighting Cancer with Nanoparticle Medicines: The Nanoscale Matters," MRS Bull. 37, 828 (2012). B. Xu, Y. Bhawe and M. E. Davis, "Spinel metal oxide-alkali carbonate-based, low-temperature thermochemical cycles for water splitting and CO2 reduction," Chem. Mater. 25, 1564 (2013). R. Gounder and M. E. Davis, "Beyond Shape Selective Catalysis of Zeolites: Hydrophobic Void Spaces in Zeolites Enable Catalysis in Liquid Water," AIChE J. 59, 3349 (2013). D. T. Wiley, P. Webster, A. Gale and M. E. Davis, "Trancytosis and Brain Uptake of Transferrin-Containing Nanoparticles by Tuning Avidity to Transferring Receptor," Proc. Nat. Acad. Sci. USA, 110, 8662 (2013). H. Han and M. E. Davis, "Targeted Nanoparticles Assembled via Complexation of Boronic Acid-Containing Targeting Moieties to Diol-Containing Polymers," Bioconj. Chem., 24, 669 (2013). H. Han and M. E. Davis, "Single Antibody, Targeted Nanoparticle Delivery of Camptothecin," Molec. Pharmaceut., 10, 2558 (2013). R. Gounder and M. E. Davis, "Titanium-beta zeolites catalyze the stereospecific isomerization of D-glucose to L-sorbose via intramolecular C5-C1 hydride shift," ACS Catal. 3, 1469 (2013). G. J. Weiss, J. Chao, J. D. Neidhart, R, K. Ramanathan, D. Bassett, J. A. Neidhart, C. H. J. Choi, W. Chow, V. Chung, S. J. Forman, E. Gurney, J. Hwang, D. L. Kalinoski, M. Koczywas, J. Longmate, R. J. Melton, R. Morgan, J. Oliver, J. J. Peterkin, J. L. Ryan, T. Schluep, T. W. Synold, P. Twardowski, M. E. Davis and Y. Yen, "First in-human phase 1/2a trial of CRLX101, a cyclodextrin-containing polymer-camptothecin nanopharmaceutical in patients with advanced solid tumor malignancies," Invest. New Drugs, 31, 986 (2013). J. E. Zuckerman and M. E. Davis, "Targeted therapeutics to the glomerulus with nanoparticles," Adv. Chronic Kidney Disease, 20, 500 (2013). R. Gounder and M. E. Davis, "Monosaccharide and Disaccharide Isomerization over Lewis Acid Sites in Hydrophobic and Hydrophilic Molecular Sieves," J. Catal., 308, 176 (2013). S. Eliasof, D. Lazarus, C. G. Peters, R. I. Case, R. O. Cole, J. Hwang, T. Schluep, J. Chao, J. Lin, Y. Yen, H. Han, D. Wiley, J. E. Zuckerman and M. E. Davis, "Correlating preclinical animal studies and human clinical trials of a multifunctional, polymeric nanoparticle," Proc. Nat. Acad. Sci. USA, 110, 15127 (2013). M. E. Davis, "Zeolites from a Materials Perspective," Chem. Mater. 26, 239 (2014). R. Bermejo-Deval, M. Orazov, R. Gounder, S. J. Hwang and M. E. Davis, "Active Sites in Sn-Beta for Glucose Isomerization to Fructose and Epimerization to Mannose," ACS Catal. 4, 2288 (2014). J. J. Pacheco and M. E. Davis, "Synthesis of terephthalic acid via Diels-Alder reactions with ethylene and oxidized variants of 5-hydroxymethylfurfural," Proc. Nat. Acad. Sci. USA 111, 8363 (2014). J. E. Schmidt, M. Deem and M. E. Davis, "Synthesis of a Specified, Silica Molecular Sieve using Computationally Predicted Organic Structure Directing Agents," Angew. Chem. Int. Ed., 53, 8372 (2014). J. E. Zuckerman, I. Gritli, A. Tolcher, J. D. Heidel, D. Lim, R. Morgan, B. Chmielowski, A. Ribas, M. E. Davis and Y. Yen, "Correlating animal and human phase Ia/Ib clinical data with CALAA-01, a targeted, polymer-based nanoperticle containing siRNA," Proc. Nat. Acad. Sci. USA, 111,11449 (2014). S. Caratzoulas, M. E. Davis, R. J. Gorte, R. Gounder, R. F. Lobo, V. Nikolakis, S. I. Sander, M. A. Snyder, M. Tsapatsis and D. Vlachos, "Challenges and Insights into Acid-catalyzed Transformation of Sugars," J. Phys. Chem. C, in press. J. E. Schmidt, S. I. Zones, D. Xie and M. E. Davis, "The Synthesis of Aluminophosphate and Germanosilicate LTA using a Triquaternary Structure Directing Agent," Micropor. Mesopor. Mat., in press. S. Gaur, Y. Wang, L. Kretzner, L. Chen, T. Yen, X. Wu, Y.-C. Yuan, M. Davis and Y. Yen, "Pharmacodynamic and pharmacogenomic study of the nanoparticle conjugate of camptothecin CRLX101 for the treatment of cancer," Nanomedicine, in press.