Wark, Alastair - University of Strathclyde - Department of Pure & Applied Chemistry

个人简介

Alastair Wark started his career with a BSc in Applied Chemistry in 1996 at the University of Strathclyde. He completed his PhD research in 2000 under the joint supervision of Dr Len Berlouis and Dr Frank Cruikshank at Strathclyde and also working with Prof. Pierre-Francois Brevet at the EPFL, Lausanne, Switzerland. Following post-doctoral research at EPFL he was awarded a Lindemann Trust Fellowship in 2001and joined the laboratories of Prof. Rob Corn at the University of Wisconsin-Madison. After moving across to the University of California-Irvine with Rob’s group and a Project Scientist position, Alastair returned to the Chemistry Department in late 2007 as a Lecturer in Nanometrology.

研究领域

My research focus is based around the synthesis, functionalization and analytical applications of novel nanomaterials alongside the development of techniques capable of optically imaging and tracking single nanoparticles and molecules. The advantages of these materials for nanometrology and bioanalytical science is that optical measurements can be performed to monitor biomolecular interactions in real-time. As well as developing robust methodologies for ultrasensitive bioaffinity detection at target concentrations approaching just a few molecules, we are also exploring the use of multimodal imaging techniques for monitoring nanoparticle-cellular interactions. This involves developing hybrid nanostructures which can be used for tackling research challenges requiring dynamic measurements in complex biological environments. Consequently, my research is highly multidisciplinary and I have enjoyed successfully collaborating with researchers from across the biology, physics, engineering and medicine research fields.

近期论文

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Gold suprashells : enhanced photothermal nanoheaters with multiple LSPR for broadband SERSPaterson Sureyya, Thompson Sebastian A., Wark Alastair W., de la Rica RobertoJournal of Physical Chemistry C, (2017)http://dx.doi.org/10.1021/acs.jpcc.6b12792 Light-triggered inactivation of enzymes with photothermal nanoheatersThompson Sebastian A., Paterson Sureyya, Azab Marwa M. M., Wark Alastair W., de la Rica RobertoSmall, (2017)http://dx.doi.org/10.1002/smll.201603195 Gel electrophoretic analysis of differently shaped interacting and non-interacting bioconjugated nanoparticlesKim Suhee, Wark Alastair W., Lee Hye JinRSC Advances Vol 6, pp. 109613-109619, (2016)http://dx.doi.org/10.1039/c6ra23948j Time-lapse measurement of single-cell response to nanomaterial : a microfluidic approachCunha Matos Carlota, Millington Owain, Wark Alastair, Zagnoni Michele20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016), pp. 377-378, (2016) Real-time assessment of nanoparticle-mediated antigen delivery and cell responseCunha-Matos Carlota A., Millington Owain R., Wark Alastair W., Zagnoni MicheleLab on a Chip Vol 16, pp. 3374-3381, (2016)http://dx.doi.org/10.1039/C6LC00599C Self-assembly of gold supraparticles with crystallographically aligned and strongly coupled nanoparticle building blocks for SERS and photothermal therapyPaterson S., Thompson S. A., Gracie J., Wark A. W., de la Rica R.Chemical Science Vol 7, pp. 6232-6237, (2016)http://dx.doi.org/10.1039/C6SC02465C