Tomkinson, Nick - University of Strathclyde - Department of Pure & Applied Chemistry

个人简介

Nick Tomkinson studied Chemistry at The University of Sheffield and received his BSc in 1992 and his Ph.D. in 1995 under the supervision of Dr. D. Neville Jones and Professor Jim Anderson. Postdoctoral studies with Dr. Tim Willson at GlaxoSmithKline, Research Triangle Park, North Carolina (1996–1998) followed. Nick was appointed to the staff at Cardiff University in 1999 and was an EPSRC Advanced Research Fellowship (2004–2009). He moved to his current position at the University of Strathclyde in June 2011.

近期论文

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Molecular basis of fatty acid selectivity in the zDHHC family of S-acyltransferases revealed by click chemistryGreaves Jennifer, Munro Kevin R., Davidson Stuart C., Riviere Matthieu, Wojno Justyna, Smith Terry K., Tomkinson Nicholas C.O., Chamberlain Luke H.Proceedings of the National Academy of Sciences Vol 114, (2017) A cluster of palmitoylated cysteines are essential for aggregation of cysteine-string protein mutants that cause neuronal ceroid lipofuscinosisDiez Ardanuy Cinta, Greaves Jennifer, Munro Kevin R., Tomkinson Nicholas C.O., Chamberlain Luke H.Scientific Reports, (2017)http://dx.doi.org/10.1038/s41598-017-00036-8 Clinical progress and pharmacology of small molecule bromodomain inhibitorsTheodoulou Natalie H, Tomkinson Nicholas CO, Prinjha Rab K , Humphreys Philip GCurrent Opinion in Chemical Biology Vol 33, pp. 58-66, (2016)http://dx.doi.org/10.1016/j.cbpa.2016.05.028 Stereoselective synthesis of alkylidene phthalidesDragan Andrei, Jones D. Heulyn, Kennedy Alan R., Tomkinson Nicholas C. O.Organic Letters Vol 18, pp. 3086-3089, (2016)http://dx.doi.org/10.1021/acs.orglett.6b01203 Alkene dioxygenation with malonoyl peroxides : synthesis of ?-lactones, isobenzofuranones and tetrahydrofuransAlamillo-Ferrer Carla, Karabourniotis-Sotti Marianna, Kennedy Alan R., Campbell Matthew, Tomkinson Nicholas C. O.Organic Letters, (2016)http://dx.doi.org/10.1021/acs.orglett.6b01253 C–H arylation of heterocyclic N oxides through in-situ diazotisation of anilines without added promoters : a green and selective coupling processColleville Aymeric Pierre, Horan Richard A.J., Olazabal Sandrine, Tomkinson Nicholas C. O.Organic Process Research and Development, (2016)http://dx.doi.org/10.1021/acs.oprd.6b00117