Suckling, Colin - University of Strathclyde - Department of Pure & Applied Chemistry

个人简介

Colin Suckling has been Freeland Professor of Chemistry at the University of Strathclyde since 1989. During the 1990s until 2002, he served successively as Dean of the Faculty of Science, Deputy Principal, and Vice Principal of the University of Strathclyde. Much of Professor Suckling's work during that time was strategic including the development of inter-institutional and interdisciplinary research partnerships notably the research collaboration with the University of Glasgow (WestCHEM), which was recognized publicly with the award of OBE in 2006. Recent and current research interests focus on the synthesis and properties of heterocyclic compounds designed as molecular probes for biological systems or as drugs. Particular progress has been made in the field of fused pyrimidine compounds with anticancer and antiparasite activity and in the field of minor groove binders for DNA with antibacterial activity. Several discoveries are entering pre-clinical development. Professor Suckling's standing in the field of heterocyclic chemistry has been recognized by the award of the Adrien Albert Lectureship of the Royal Society of Chemistry (2009-10) and his appointment as chairman of the 2011 International Congress of Heterocyclic Chemistry to be held in Glasgow.

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Four pyrrole derivatives used as building blocks in the synthesis of minor-groove bindersKennedy Alan R., Khalaf Abedawn I., Scott Fraser J., Suckling Colin J.Acta Crystallographica Section E: Structure Reports Vol 73, pp. 254-259, (2017)http://dx.doi.org/10.1107/S2056989017001177 Selective anti-malarial minor groove bindersScott Fraser J., Khalaf Abedawn I., Duffy Sandra, Avery Vicky M., Suckling Colin J.Bioorganic and Medicinal Chemistry Letters Vol 26, pp. 3326-3329, (2016)http://dx.doi.org/10.1016/j.bmcl.2016.05.039 Testing small molecule analogues of acanthocheilonema viteae immunomodulator ES-62 against clinically relevant allergensJanicova L., Rzepecka J., Rodgers D.T., Doonan J., Bell K., Lumb F.E., Suckling C.J., Harnett M.M., Harnett W.Parasite Immunology Vol 38, pp. 340-351, (2016)http://dx.doi.org/10.1111/pim.12322 An evaluation of minor groove binders as anti-Trypanosoma brucei brucei therapeuticsScott Fraser J., Khalaf Abedawn I., Giordani Federica, Wong Pui Ee, Duffy Sandra, Barrett Michael, Avery Vicky M., Suckling Colin J.European Journal of Medicinal Chemistry Vol 116, pp. 116-125, (2016)http://dx.doi.org/10.1016/j.ejmech.2016.03.064 An evaluation of minor groove binders as anti-lung cancer therapeuticsScott Fraser, Khalaf Abedawn, Suckling Colin, Carter Katharine, Grant Mary, Henderson Catherine, Westrop Gareth, Watson DavidBioorganic and Medicinal Chemistry Letters, (2016)http://dx.doi.org/10.1016/j.bmcl.2016.06.040 Structurally diverse mitochondrial branched chain aminotransferase (BCATm) leads with varying binding modes identified by fragment screeningBorthwick Jennifer A., Ancellin Nicolas, Bertrand Sophie M., Bingham Ryan P., Carter Paul S., Chung Chun-wa, Churcher Ian, Dodic Nerina, Fournier Charlène, Francis Peter L., Hobbs Andrew, Jamieson Craig, Pickett Stephen D., Smith Sarah E., Somers Donald O'N., Spitzfaden Claus, Suckling Colin J., Young Robert J.Journal of Medicinal Chemistry Vol 59, pp. 2452-2467, (2016)http://dx.doi.org/10.1021/acs.jmedchem.5b01607