Jamieson, Craig - University of Strathclyde - Department of Pure & Applied Chemistry

个人简介

Craig Jamieson earned his BSc (Hons) in Chemistry at the University of Glasgow in 1996. His PhD studies were carried out under the direction of Professor R Ramage at the University of Edinburgh (1999). Following postdoctoral research under the supervision of Professor S V Ley at the University of Cambridge, in 2001 he was appointed as a Principal Scientist in GlaxoSmithKline's Discovery Medicinal Chemistry group working on a range of exploratory medicinal chemistry programmes. In 2004, Dr Jamieson joined Organon Laboratories (later Merck Research Labs) as a Group Leader in the Medicinal Chemistry Department, with responsibility for hit to clincal candidate optimisation. In August 2010 he was appointed as a John Anderson Research Lecturer in Chemical Biology, based in the Department of Pure and Applied Chemistry at the University of Strathclyde.

研究领域

A major area of focus for our research continues to be in the Chemistry-Biology-Medicine continuum. In this regard, we have a number of active programmes centred around hit and lead identification on disease targets and mechanisms in areas of significant societal need, particularly in diseases of ageing. Allied to our work in the medicinal chemistry sphere, we also have a keen interest in the development of novel, enabling synthetic methodologies to enhance the armamentarium of molecule makers working in our arena. We collaborate with groups and industrial partners locally, nationally and globally in order to effectively meet our research goals.

近期论文

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Amidation of unactivated ester derivatives mediated by trifluoroethanolMcPherson Christopher G., Caldwell Nicola, Jamieson Craig, Simpson Iain, Watson Allan J. B.Organic and biomolecular chemistry, (2017)http://dx.doi.org/10.1039/C7OB00593H Rational design of autotaxin inhibitors by structural evolution of endogenous modulatorsKeune Willem-Jan, Potjewyd Frances, Heidebrecht Tatjana, Salgado-Polo Fernando, Macdonald Simon J. F., Chelvarajan Lakshman, Abdel Latif Ahmed, Soman Sony, Morris Andrew J., Watson Allan J. B., Jamieson Craig, Perrakis AnastassisJournal of Medicinal Chemistry Vol 60, pp. 2006-2017, (2017)http://dx.doi.org/10.1021/acs.jmedchem.6b01743 Emergence of small molecule non-RGD-mimetic inhibitors for RGD integrinsMiller Lisa M., Pritchard John M., Macdonald Simon J. F., Jamieson Craig, Watson Allan J. B.Journal of Medicinal Chemistry, (2017)http://dx.doi.org/10.1021/acs.jmedchem.6b01711 Structure-activity relationships of small molecule autotaxin inhibitors with a discrete binding modeMiller Lisa M., Keune Willem-Jan, Castagna Diana, Young Louise C., Duffy Emma L., Potjewyd Frances, Salgado-Polo Fernando, Garcia Paloma Engel, Semaan Dima, Pritchard John M., Perrakis Anastassis, Macdonald Simon J. F., Jamieson Craig, Watson Allan J. B.Journal of Medicinal Chemistry Vol 60, pp. 722-748, (2017)http://dx.doi.org/10.1021/acs.jmedchem.6b01597 Investigation of a bicyclo[1.1.1]pentane as a phenyl replacement within an LpPLA2 inhibitorMeasom Nicholas, Down Kenneth D., Hirst David J., Jamieson Craig, Manas Eric S., Patel Vipulkumar K., Somers Donald O.Medicinal Chemistry Letters Vol 7, (2016)http://dx.doi.org/10.1021/acsmedchemlett.6b00281 Scope and limitations of a DMF bio-alternative within Sonogashira cross-coupling and Cacchi-type annulationWilson Kirsty, Kennedy Alan, Murray Jane, Greatex Ben, Jamieson Craig, Watson AllanBeilstein Journal of Organic Chemistry Vol 12, pp. 2005-2011, (2016)http://dx.doi.org/10.3762/bjoc.12.187