Haddrill, Penelope - University of Strathclyde - Department of Pure & Applied Chemistry

研究领域

My research background is in molecular and population genetics, and I am developing research in forensic biology by applying this experience to questions of a forensic nature. I am interested in the development of nucleic acid (DNA and RNA) assays to determine the source, type and time of deposition of forensic samples such as single or mixed body fluid stains, and the potential for these assays to be carried out in situ at crime scenes using chemical sensors. I am currently involved in a project to deliver a series of knowledge exchange workshops on RNA profiling to the Scottish Police Authority Forensic Services, to determine the potential for implementation of RNA analysis in Scottish casework. I am also interested in the development and use of marker panels for determining phenotypic, ancestry and age information about unknown DNA sample donors, which could provide intelligence to police investigations. It is clear that next-generation sequencing technologies are increasingly being used in forensic genetic analyses, and I am exploring the potential for these technologies to be applied to whole-genome sequencing of mixed DNA samples, in order to determine the relative representation of the different contributors to the mixture

近期论文

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The discovery, distribution, and evolution of viruses associated with Drosophila melanogasterWebster Claire L., Waldron Fergal M., Robertson Shaun, Crowson Daisy, Ferrari Giada, Quintana Juan F., Brouqui Jean-Michel, Bayne Elizabeth H., Longdon Ben, Buck Amy H., Lazzaro Brian P., Akorli Jewelna, Haddrill Penelope R., Obbard Darren J.PLOS Biology Vol 13, pp. 1-33, (2015)http://dx.doi.org/10.1371/journal.pbio.1002210 Strain-specific and pooled genome sequences for populations of Drosophila melanogaster from three continentsBergman Casey M., Haddrill Penelope RF1000Research Vol 4, (2015)http://dx.doi.org/10.12688/f1000research.6090.1 The relation between recombination rate and patterns of molecular evolution and variation in Drosophila melanogasterCampos José L, Halligan Daniel L, Haddrill Penelope R, Charlesworth BrianMolecular Biology and Evolution Vol 31, pp. 1010-1028, (2014)http://dx.doi.org/10.1093/molbev/msu056 Estimation of the spontaneous mutation rate per nucleotide site in a Drosophila melanogaster full-sib familyKeightley Peter D, Ness Rob W, Halligan Daniel L, Haddrill Penelope RGenetics Vol 196, pp. 313-320, (2014)http://dx.doi.org/10.1534/genetics.113.158758 Codon usage bias and effective population sizes on the X chromosome versus the autosomes in Drosophila melanogasterCampos Jose L, Zeng Kai, Parker Darren J, Charlesworth Brian, Haddrill Penelope RMolecular Biology and Evolution Vol 30, pp. 811-823, (2013)http://dx.doi.org/10.1093/molbev/mss222 Variation in male and female mating behaviour among different populations of the two-spot ladybird, Adalia bipunctata (Coleoptera: Coccinellidae)Haddrill Penny, Majerus Michael E N, Shuker David MEuropean Journal of Entomology Vol 110, pp. 87-93, (2013)