Dufton, Mark - University of Strathclyde - Department of Pure & Applied Chemistry

研究领域

Bioinformatics. Software for topological analysis and interpretation, leading to prediction of topomorphic sites in biological macromolecules. Application to discovery of new generation of topomorphic drugs and understanding the process of natural evolution for application to protein engineering. Collaborative partners: Dept of Computer & Information Sciences (Dr John Wilson); Dept of Pharmacy (Prof Simon Mackay). Snake venom chemistry, especially the supportive role of venom enzymes in enhancing the efficacy of the key toxins. Collaborative partner: Dr John Parkinson (Pure & Applied Chemistry). Venom action, as a guide for the development of protein-based drugs and strategies for enhancing the speed and efficacy of drug delivery. Biomolecular structures and mechanisms, and their evolutionary history. Role of biomolecule chain fold topology in determining directionality of structural and functional evolution. Drug action through site specific perturbation of chain fold topologies in proteins and nucleic acids.

近期论文

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Metabolomic profiling of the effects of melittin on cisplatin resistant and cisplatin sensitive ovarian cancer cells using mass spectrometry and biolog microarray technologyAlonezi Sanad, Tusiimire Jonans, Wallace Jennifer, Dufton Mark J., Parkinson John A., Young Louise C., Clements Carol J., Park Jin Kyu, Jeon Jong Woon, Ferro Valerie A., Watson David G.Metabolites Vol 6, (2016)http://dx.doi.org/10.3390/metabo6040035 Effect of bee venom and its fractions on the release of pro-inflammatory cytokines in PMA-differentiated U937 cells co-stimulated with LPSTusiimire Jonans, Wallace Jennifer, Woods Nicola, Dufton Mark J., Parkinson John A., Abbott Grainne, Clements Carol J., Young Louise, Park Jin Kyu, Jeon Jong Woon, Ferro Valerie A., Watson David G.Vaccines Vol 4, (2016)http://dx.doi.org/10.3390/vaccines4020011 Local pre-processing for node classification in networks : application in protein-protein interactionFoley Christopher Eric, Al Azwari Sana Mohammad M, Dufton Mark, Ross Isla, Wilson JohnInformation Technology in Bio- and Medical InformaticsLecture Notes in Computer Science Vol 8060, pp. 32-46, (2013)http://dx.doi.org/10.1007/978-3-642-40093-3_3 Using microenvironments to identify allosteric binding sitesFoley Christopher Eric, Al Azwari Sana Mohammad M, Dufton Mark, Wilson John2012 IEEE International Conference on Bioinformatics and Biomedicine (BIBM 2012), pp. 411-415, (2012)http://dx.doi.org/10.1109/BIBM.2012.6392711 The drug discovery portal : a computational platform for identifying drug leads from academiaClark Rachel, Johnston Blair, Mackay Simon, Breslin Catherine, Robertson Murray, Sutcliffe Oliver Brook, Dufton Mark, Harvey AlanCurrent Pharmaceutical Design Vol 16, pp. 1697-1702, (2010)http://dx.doi.org/10.2174/138161210791164018 The drug discovery portal : a computational platform for identifying drug leads from academiaClark R.L., Johnston B.F., Mackay S.P., Breslin C.J., Robertson Murray, Sutcliffe O.B., Dufton M.J., Harvey A.L.Current Pharmaceutical Design Vol 16, pp. 1697-1702, (2010)http://dx.doi.org/10.2174/138161210791164018