个人简介

Education: B. Sc., Jilin University; Ph.D., State University of New York

研究领域

Nucleic acid chemistry

The focuses of my group are mainly on the following research areas: [1] Atomic force microscopic studies of binding interactions between circular DNA and topoisomerases. Zhaoqi Yang, Dawei Li, Shuhui Hiew, Magdeline Taotao Ng, Weixing Yuan, Haibin Su, Fangwei Shao and Tianhu Li, Recognition of forcible curvature in circular DNA by human topoisomerase I, Chem. Commun., 2011, 47, 11309-1131 [2] Atomic force microscopic studies of formation of catenated DNA catalyzed by Cre recombinase. Zhaoqi Yang, Dawei Li and Tianhu Li, Design and synthesis of catenated rings based on toroidal DNA structures, Chem. Commun., 2011, 47, 11930-11932 [3] Examination of correlation between DNA backbone self-crossing and DNA intrinsic curvature on the basis of AFM. Li, D.;* Yang, Z.; Zhao G.; Long, Y.; Lv, B.; Li, C.; Hiew, S,; Ng, M. T. T.; Guo, J. J.; Tan H. K,; Zhang, H.; Li T.* Manipulating DNA writhe through varying DNA sequences. Chem. Commun., 2011, 47(26), 7479-7481 [4] Manipulation of formation of negative right handed and left handed positive DNA supercoils with desired writhe number. Dawei Li, Zhaoqi Yang, Yi Long, Guanjia Zhao, Bei Lv, Shuhui Hiew, Magdeline Tao Tao Ng, Juanjuan Guo, HongKee Tan, Hao Zhang, Weixing Yuan, Haibin Su and Tianhu Li, Precise engineering and visualization of signs and magnitudes of DNA writhe on the basis of PNA invasion. Chem. Comm., 2011, 47, 10695-10697 [5] “General Topological Conservation Law of DNA”: The original form of “Topological Conservation Law” given by F. B. Fuller in 1970s: Lk -Tw = Wr The new form of “General Topological Conservation Law of DNA” introduced by our group: Lk -Tw + Nb = Wb + Wn = Wr (see: Dawei Li, Zhaoqi Yang, Bei Lv, Tianhu Li , Observation of backbone self-crossings of organismal DNAs through atomic force microscopy, Bioorganic & Medicinal Chemistry Letters 22 (2012) 833–836)

近期论文

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Qiong Lei, Tianhu Li, Functional monoesters of jojoba oil can be produced by enzymatic interestification: Reaction analysis and structural characterization, 2014, European Journal of Lipid Science and Technology, in press Qiong Lei, Wilson Liangwei Lee, Tianhu Li, Design and synthesis of 1,3-dicapryloyl-2-acetylglycerol as molecular probe for TAG metabolism study, European Journal of Lipid Science and Technology, Volume 115, Issue 2, Pages 232–238, 2013 Sai Ba, Qiong Lei, Chee Wee Ng, Hao Zhang, Dejian Huang, Tianhu Li, Synthesis of New Types of Brominated Diesters as Potential Food Emulsifiers, 2013, GSTF International Journal of Chemical Sciences, 1(1), 40-47. Li, Cheng; Sun, Jingcan; Li, Tianhu; Liu, Shao-Quan; Huang, Dejian, Chemical and enzymatic synthesis of a library of 2-phenethyl esters and their sensory attributes, 2014, Food Chemistry, 154, 205-210 Li, Cheng; Sun, Jingcan; Fu, Caili; Yu, Bin; Liu, Shao Quan; Li, Tianhu; Huang, Dejian, Synthesis and evaluation of odour-active methionyl esters of fatty acids via esterification and transesterification of butter oil, 2014, Food Chemistry, 145, 796-801 Dawei Li, Bei Lv, Hao Zhang, Jasmine Yiqin Lee and Tianhu Li, Positive supercoiling affiliated with nucleosome formation repairs non-B DNA structures, 2014, Chemical Commun., 50, 10641-10644 Bei Lv, Dawei Li, Hao Zhang, Jasmine Yiqin Lee and Tianhu Li, DNA gyrase-driven generation of a G-quadruplex from plasmid DNA, 2013, Chem. Commun.,49, 8317-8319 Hao Zhang, Juanjuan Guo, Dawei Li, Magdeline Tao Tao Ng, Jasmine Yiqin Lee, Bei Lv, Chee Wee Ng, Selvi Lee, Fangwei Shao, Tianhu Li, Confirmation of quinolone-induced formation of gyrase–DNA conjugates using AFM, 2013, Bioorganic & Medicinal Chemistry Letters, 23, 4622-4626 Tan, H. K., Li, D., Gray, R. K., Yang, Z., Ng, M. T. T., Zhang, H., Tan, J. M. R., Hiew, S., Lee, J. Y., Li, T., Interference of intrinsic curvature of DNA by DNA-intercalating agents. Org. Biomol. Chem., Org. Biomol. Chem., 2012, 10, 2227-2230. Yang, Z.Q., Li, D.W., Guo, J.J., Shao, F.W, Li, T.H, Intrinsic curvature in duplex DNA inhibits Human Topoisomerase I., Bioorganic & Medicinal Chemistry Letters 22 (2012), 1322-1325. Li, D., Yang, Z., Lv, B., Li, T., Observation of backbone self-crossings of organismal DNAs through atomic force microscopy. Bioorg. Med. Chem. Lett., 2012, 22, 833-836 Wang, Y., Wang, Y., Zhan, R., Li, T., Pu, K.Y Tan, Y. C., Liu, B., Fluorescence and visual Detection of Single Nucleotide Polymorphism using Cationic Conjugated Polyelectrolyte, Langmuir., 2011, 28, 889-895 Yang, Z, Li, D., Li, D., Design and synthesis of catenated rings based on toroidal DNA structures. ChemComm., 2011, 47, 11930-11932 Li, D., Yang, Z., Yi, L., Zhao, G., Lv, B., Hiew, S., Ng, M. T. T., Guo, J., Tan, H., Zhang, H., Yuan, W., Su, H., Li, T., Precise engineering and visualization of signs and magnitudes of DNA writhe on the basis of PNA invasion. ChemComm., 2011, 47, 10695-10697 Yang, Z., Li, D., Hiew, S., Ng, M. T. T., Yuan, W., Su, H., Shao, F., Li, T., Recognition of forcible curvature in circular DNA by human topoisomerase I, ChemComm., 2011, 47, 11309-11311 Li, D.;* Yang, Z.; Zhao G.; Long, Y.; Lv, B.; Li, C.; Hiew, S,; Ng, M. T. T.; Guo, J. J.; Tan H. K,; Zhang, H.; Li T.* Manipulating DNA writhe through varying DNA sequences. ChemComm., 2011, 47(26), 7479-7481 Wang, H.; Xu, W.; Zhang, H.; Li, D.; Yang, Z.; Xie, X.; Li, T.; Liu, X., EcoRI-Modified Gold Nanoparticles for Dual-Mode Colorimetric Detection of Magnesium and Pyrophosphate Ions. SMALL., 2011, 7(14), 1987-1992. Xie, X.; Xu, W.; Li, T.; Liu, X., Colorimetric detection of HIV-1 ribonuclease H activity by gold nanoparticles. SMALL., 2011 7(10), 1393-1396 Wong, W. C.; Zhuang, J. Y.; Ng, S. L. L.; New, L. L. L.; Hiew, S.; Guo, J. J.; Yang, Z. Q.; Li, T. H., Conformational organizations of G-quadruplexes composed of d(G(4)T(n))(3)G(4). Bioorg. Med. Chem. Lett., 2010, 20(15), 4689-4692. Xu, W.; Xue, X. J.; Li, T. H.; Zeng, H. Q.; Liu, X. G., Ultrasensitive and selective colorimetric DNA detection by nicking endonuclease assisted nanoparticle amplification. Angew. Chem. Int. E., 2009, 48(37), 6849-6852. Ng, M. T. T.; Li, X. M.; Wang, Y. F.; Zhou, T. Y.; Yang, Z. Q.; Foo, H. Y.; Li, T. H., Site-Specific Cleavage of G-quadruplexes formed by oxytricha telometric repeats. Aust. J. Chem., 2009, 62(9), 1189-1193. Zhou, T. Y.; Li, X. M.; Ng, M. T. T.; Wang, Y. F.; Quek, N. M.; Luo, J.; Yuan, W. X.; Tan, C. H.; Zeng, H. Q.; Li, T. H., Synthesis and characterization of circular structures of i-motif tagged with fluoresceins. Bioconjugate Chem., 2009, 20(4), 644-647. Chua, S. T.; Quek, N. M.; Li, M.; Ng, M. T. T.; Yuan, W. X.; Chua, M. L.; Guo, J. J.; Koh, L. E.; Ye, R. J.; Li, T. H., Nick-containing oligonucleotides as human topoisomerase I inhibitors. Bioorg. Med. Chem. Lett., 2008, 19(3), 618-623. Li, X. M.; Ng, M. T. T.; Wang, Y. F.; Zhou, T. Y.; Chua, S. T.; Yuan, W. X.; Li, T. H., Site-specific self-cleavage of G-quadruplexes formed by human telemetric repeats. Bioorg. Med. Chem. Lett., 2008, 18(20), 5576-5580. Wang, Y. F.; Ng, M. T. T.; Zhou, T. Y.; Li, X. M.; Tan, C. H.; Li, T. H., C3-Spacer-containing circular oligonucleotides as inhibitors of human topoisomerase I. Bioorg. Med. Chem. Lett., 2008, 18(12), 3597-3602.