个人简介

Education: B.Sc. (Hon.), Polytechnic of North London; Ph.D., Australian National University, Post-doc: Toronto, Chicago

研究领域

Asymmetric synthesis/Organometallic Chemistry

The research projects pursued by my research team involve asymmetric hydroamination and hydrophosphination reactions, insertion and coupling reactions, synthesis and coordination chemistry of chiral sulfoxide complexes, development of 2-D ROESY NMR techniques in stereochemical analysis, asymmetric synthesis of phosphines and heterocycles and development of chiral metal complexes for asymmetric catalysis. We are particularly interested in the synthesis of enantiomerically pure tertiary phosphines and diphosphines containing both the stereogenic phosphorus centres and some selected functionalities. This class of functionalized P-chiral ligands has long been considered as powerful auxiliaries for homogenous asymmetric catalysis. An efficient approach to generate the desired stereoisomeric form of a particular ligand by means of an unusual exo-endo stereochemically controlled asymmetric Diels-Alder reaction, using a family of specially designed chiral organometallic complexes as the reaction promoter shave been developed. With these catalysts, it is now possible to produce one particular target molecule in a controllable and specific manner. Currently, these findings are applied to the synthesis of new anti-cancer gold drugs. Thus far, preliminary biological tests indicate that these new drugs exhibit high activity towards various human cancerous diseases with minimal side effects. The catalytic properties of gold complexes containing these newly generated chiral phosphines are also being investigated.

近期论文

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Leung PH, McLaughlin GM, Martin JWL, Wild SB, "Resolution involving metal complexation, Synthesis and resolution of (±)-2-mercaptoethyl)methylphenylarsine", Inorganic Chemistry, 1986, 25, 3392. Leung PH, McLaughlin GM, Martin JWL, Wild SB, "Diastereiosm in square-planar complexes of bidentate nickel, palladium and platinum containing asymmetric 2-mercaptoethyl-substituted tertiary arsines and phosphines", Inorganic Chemistry, 1986, 25, 3392. Kerr PG, Leung PH, Wild SB, "Optically active arsenic macrocycles. Stereospecific synthesis of enantiomers and diastereomers of 14-membered trans-As2S2 chelating macrocycles containing resolved asymmetric tertiary arsenic donors", J American Chem. Soc., 1987, 109, 4321. Bergens SH, Leung PH, Bosnich B, Rheingold AL, "Synthesis and structure of a biphenanthrol palladium complex displaying an unusual bonding mode", Organometallics, 1990, 9, 2406. Tan SF, Leung PH, Sin WC, "Catalytic autoxidation of p-anisaldehyde and styrene by a cobalt bis-schiff base complex", Transition Metal Chem., 1991, 16, 542. Chooi SYM, Leung PH Ng SC, Quek GH and Sim KY, "A Simple Route to Optically Pure 2,3-Diaminobutane", Tetrahedron Asymmetry, 1991, 2, 981. Chooi SYM, Hor TSA, Leung PH, Mok KF, "Stereochemical Investigations of Coordinated Sulfur Stereocenters. X-Ray Structure of Diastereomers of (–)-[Pd{(R)-CH3CH(1-C10H6)NMe2-C2N}{Ph2PCH2CH2SMe-P,S}]PF6", Inorganic Chemistry, 1992, 31, 1494. Leung PH, Willis AC, Wild SB, "Resolution involving metal complexation. Optical resolution and photochemical rearrangement of (±)-2-mercaptoethyl)methylphenylphosphine", Inorganic Chemistry, 1992, 31, 1406. Chooi SYM, Leung PH, Lim CC, Mok KF, Quek GH and Sim KY, Tan MK, "Versatile Chiral Palladium(II) Complexes for Enantiomeric Purities of 1,2-Diamines", Tetrahedron Asymmetry, 1992, 3, 529. Chooi SYM, Leung PH, Mok KF, "Palladium(II) and Platinum(II) Complexes with Chelating Sulfinyl Functions", Inorganica Chimica Acta, 1993, 205, 243. Chooi SYM, Siah SY, Leung PH, Mok KF, "Optical Resolution and Chelating Properties of (±)-(2-Methylsulfinyl)ethyl-diphenylarsine and Its phosphine Analogue", Inorganic Chemistry, 1993, 32, 4812. Zhou MS, Xu Y, Koh LL, Mok KF, Leung PH, Hor TSA, "[Pt2(µ-S)2(PPh3)4] as a metalloligand towards main group Lewis acids: A Mexican-hat-like structure for [Pt2Tl(µ3-S)2(PPh3)4]X (X = NO3, PF6) with a two coordinate angular Tl(I)", Inorganic Chemistry, 1993, 32, 1875. Zhou MS, Xu Y, Lam CF, Koh LL, Mok KF, Leung PH, Hor TSA, "[Pt2(µ-S)2(PPh3)4] as a metalloligand towards main group Lewis acids: Crystal structures of two complex adducts of lead nitrate, [(PPh3)4Pt2(µ3-S)2-Pb(NO3)2] and [(PPh3)4Pt2(µ3-S)2Pb(NO3)]PF6", Inorganic Chemistry, 1993, 32, 4660. Chooi SYM, Leung PH, Sim KY, Tan KS, Kon OL, "In Vitro Cytotoxic Properties of Gold(I) and Platinum(II) Compounds Containing Asymmetric (2-Methylsulfinyl)ethyl-diphenylarsine and Its phosphine Analogue", Tetrahedron Asymmetry, 1994, 5, 49. Chooi SYM, Tan MK, Leung PH, Mok KF, "Stereochemical Investigations of Bis(bidentate)-Palladium(II) Complexes. Transmission of Ring Chiralities Between Chelating Amine Ligands via Their Prochiral N-Methyl Substituents", Inorganic Chemistry, 1994, 33, 3096. Aw BH, Leung PH, "A Simple Route to An Optically Pure Diphosphine Ligand Containing a Phosphorus Stereogenic Centre", Tetrahedron Asymmetry, 1994, 5, 1167. Siah SY, Leung PH, Mok KF, "Palladium(II) and Platinum(II) Complexes with a Novel P-S(O)-P Tridentate Ligand", Polyhedron, 1994, 13, 3253. Chooi SYM, Ranford JD, Leung PH, Mok KF, "Stereoelectronic Effects on the Chelating Properties of (2-Methylsulfinyl)ethyl-diphenylarsine and Its phosphine Analogue", Tetrahedron Asymmetry, 1994, 5, 1805. Lim CC, Leung PH, Sim KY, "Resolution and Enantiomeric Purities of (2-Methylsulfinyl)ethylamine", Tetrahedron Asymmetry, 1994, 5, 1883. Zhou MS, Xu Y, Lam CF, Koh LL, Mok KF, Leung PH, Hor TSA, "[Pt2(µ-S)2(PPh3)4] as a metalloligand towards main group Lewis acids: The first square-pyramidal structure of an In(III) complex adduct in (PPh3)4Pt2(µ3-S)2InCl3 and tetrahedral Ga(III) in the ion-pair [(PPh3)4Pt2(µ3-S)2GaCl2][GaCl4]", Inorganic Chemistry, 1994, 32, 1572.