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Professor John Zajicek trained in Medicine at Cambridge and St Mary’s Hospital in London. He completed a PhD in cell biology in Cambridge, moved to Plymouth in 1995 as a Consultant Neurologist, and took up the Chair of Clinical Neuroscience at Plymouth University. In Plymouth he was Director of the Peninsula Clinical Trials Unit, and Chair of the UK NIHR Nervous System Disorders Specialty Group. He has recently moved to the University of St Andrews, where he is Professor of Medicine.

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Cruz, PMR, Matthews, L, Boggild, M, Cavey, A, Constantinescu, CS, Evangelou, N, Giovannoni, G, Gray, O, Hawkins, S, Nicholas, R, Oppenheimer, M, Robertson, N, Zajicek, J, Rothwell, PM & Palace, J 2016, 'Time-and region-specific season of birth effects in multiple sclerosis in the United Kingdom' JAMA Neurology, vol 73, no. 8, pp. 954-960. DOI: 10.1001/jamaneurol.2016.1463 Zeissler, M-L, Eastwood, J, McCorry, K, Hanemann, CO, Zajicek, JP & Carroll, CB 2016, 'Delta-9-tetrahydrocannabinol protects against MPP+ toxicity in SH-SY5Y cells by restoring proteins involved in mitochondrial biogenesis' Oncotarget, vol 7, no. 29, pp. 46603-46614. DOI: 10.18632/oncotarget.10314 McGhee, DJM, Ritchie, CW, Zajicek, JP & Counsell, CE 2016, 'A review of clinical trial designs used to detect a disease-modifying effect of drug therapy in Alzheimer’s disease and Parkinson’s disease' BMC Neurology, vol 16, 92, pp. 1-13. DOI: 10.1186/s12883-016-0606-3 Freeman, JA, Hendrie, W, Creanor, S, Jarrett, L, Barton, A, Green, C, Marsden, J, Rogers, E & Zajicek, J 2016, 'Standing up in multiple sclerosis (SUMS): protocol for a multi-centre randomised controlled trial evaluating the clinical and cost effectiveness of a home-based self-management standing frame programme in people with progressive multiple sclerosis' BMC Neurology, vol 16, 62, pp. 1-10. DOI: 10.1186/s12883-016-0581-8 O'Connor, P, Comi, G, Freedman, MS, Miller, AE, Kappos, L, Bouchard, J-P, Lebrun-Frenay, C, Mares, J, Benamor, M, Thangavelu, K, Liang, J, Truffinet, P, Lawson, VJ, Wolinsky, JS, Teriflunomide Multiple Sclerosis Oral (TEMSO) Trial Group and the MRI-AC in Houston, Texas & Zajicek, JP 2016, 'Long-term safety and efficacy of teriflunomide: nine-year follow-up of the randomized TEMSO study' Neurology, vol 86, no. 10, pp. 920-930. DOI: 10.1212/WNL.0000000000002441 Scolding, N, Barnes, D, Cader, S, Chataway, J, Chaudhuri, A, Coles, A, Giovannoni, G, Miller, D, Rashid, W, Schmierer, K, Shehu, A, Silber, E, Young, C & Zajicek, J 2015, 'Association of British Neurologists: revised (2015) guidelines for prescribing disease-modifying treatments in multiple sclerosis' Practical Neurology, vol 15, no. 4, pp. 273-279. DOI: 10.1136/practneurol-2015-001139 Barrett, L, Cano, S, Zajicek, J & Hobart, J 2015, 'Lending a hand: can DASH items help ABILHAND improve manual ability measurement in multiple sclerosis?' Multiple Sclerosis Journal, vol 21, no. 5, pp. 612-621. DOI: 10.1177/1352458514549396 Ball, S, Vickery, J, Hobart, J, Wright, D, Green, C, Shearer, J, Nunn, A, Cano, MG, MacManus, D, Miller, D, Mallik, S & Zajicek, J 2015, 'The Cannabinoid Use in Progressive Inflammatory brain Disease (CUPID) trial: a randomised double-blind placebo-controlled parallel-group multicentre trial and economic evaluation of cannabinoids to slow progression in multiple sclerosis' Health Technology Assessment, vol 19, no. 12, pp. vii-viii, xxv-xxxi, 1-187. DOI: 10.3310/hta19120 McGhee, D, Parker, A, Fielding, S, Zajicek, J & Counsell, C 2015, 'Using 'dead or dependent' as an outcome measure in clinical trials in Parkinson's disease' Journal of Neurology, Neurosurgery, and Psychiatry, vol 86, no. 2, pp. 180-185. DOI: 10.1136/jnnp-2014-307703 Hosking, R & Zajicek, J 2014, 'Pharmacology: Cannabis in neurology--a potted review' Practical Neurology, vol 10, no. 8, pp. 429-30. DOI: 10.1038/nrneurol.2014.122 McGhee, DJM, Ritchie, CW, Thompson, PA, Wright, DE, Zajicek, JP & Counsell, CE 2014, 'A systematic review of biomarkers for disease progression in Alzheimer's disease' PLoS One, vol 9, no. 2, e88854. DOI: 10.1371/journal.pone.0088854 Hilton, D, Stephens, M, Kirk, L, Edwards, P, Potter, R, Zajicek, J, Broughton, E, Hagan, H & Carroll, C 2014, 'Accumulation of α-synuclein in the bowel of patients in the pre-clinical phase of Parkinson's disease' Acta neuropathologica, vol 127, no. 2, pp. 235-41. DOI: 10.1007/s00401-013-1214-6 Zajicek, J 2014, 'Future placebo-controlled trials of disease modifying therapy in relapsing multiple sclerosis would be unethical: No' Multiple Sclerosis Journal, vol 20, no. 9, pp. 1165-1166. DOI: 10.1177/1352458514536087 Beecham, AH, Patsopoulos, NA, Xifara, DK, Davis, MF, Kemppinen, A, Cotsapas, C, Shah, TS, Spencer, C, Booth, D, Goris, A, Oturai, A, Saarela, J, Fontaine, B, Hemmer, B, Martin, C, Zipp, F, D'Alfonso, S, Martinelli-Boneschi, F, Taylor, B, Harbo, HF, Kockum, I, Hillert, J, Olsson, T, Ban, M, Oksenberg, JR, Hintzen, R, Barcellos, LF, Agliardi, C, Alfredsson, L, Alizadeh, M, Anderson, C, Andrews, R, S?ndergaard, HB, Baker, A, Band, G, Baranzini, SE, Barizzone, N, Barrett, J, Bellenguez, C, Bergamaschi, L, Bernardinelli, L, Berthele, A, Biberacher, V, Binder, TMC, Blackburn, H, Bomfim, IL, Brambilla, P, Broadley, S, Brochet, B, Brundin, L, Buck, D, Butzkueven, H, Caillier, SJ, Camu, W, Carpentier, W, Cavalla, P, Celius, EG, Coman, I, Comi, G, Corrado, L, Cosemans, L, Cournu-Rebeix, I, Cree, BAC, Cusi, D, Damotte, V, Defer, G, Delgado, SR, Deloukas, P, di Sapio, A, Dilthey, AT, Donnelly, P, Dubois, B, Duddy, M, Edkins, S, Elovaara, I, Esposito, F, Evangelou, N, Fiddes, B, Field, J, Franke, A, Freeman, C, Frohlich, IY, Galimberti, D, Gieger, C, Gourraud, P-A, Graetz, C, Graham, A, Grummel, V, Guaschino, C, Hadjixenofontos, A, Hakonarson, H, Halfpenny, C, Hall, G, Hall, P, Hamsten, A, Harley, J, Harrower, T, Hawkins, C, Hellenthal, G, Hillier, C, Hobart, J, Hoshi, M, Hunt, SE, Jagodic, M, Jel?i?, I, Jochim, A, Kendall, B, Kermode, A, Kilpatrick, T, Koivisto, K, Konidari, I, Korn, T, Kronsbein, H, Langford, C, Larsson, M, Lathrop, M, Lebrun-Frenay, C, Lechner-Scott, J, Lee, MH, Leone, MA, Lepp?, V, Liberatore, G, Lie, BA, Lill, CM, Lindén, M, Link, J, Luessi, F, Lycke, J, Macciardi, F, M?nnist?, S, Manrique, CP, Martin, R, Martinelli, V, Mason, D, Mazibrada, G, McCabe, C, Mero, I-L, Mescheriakova, J, Moutsianas, L, Myhr, K-M, Nagels, G, Nicholas, R, Nilsson, P, Piehl, F, Pirinen, M, Price, SE, Quach, H, Reunanen, M, Robberecht, W, Robertson, NP, Rodegher, M, Rog, D, Salvetti, M, Schnetz-Boutaud, NC, Sellebjerg, F, Selter, RC, Schaefer, C, Shaunak, S, Shen, L, Shields, S, Siffrin, V, Slee, M, Sorensen, PS, Sorosina, M, Sospedra, M, Spurkland, A, Strange, A, Sundqvist, E, Thijs, V, Thorpe, J, Ticca, A, Tienari, P, van Duijn, C, Visser, EM, Vucic, S, Westerlind, H, Wiley, JS, Wilkins, A, Wilson, JF, Winkelmann, J, Zajicek, J, Zindler, E, Haines, JL, Pericak-Vance, MA, Ivinson, AJ, Stewart, G, Hafler, D, Hauser, SL, Compston, A, McVean, G, De Jager, P, Sawcer, SJ, McCauley, JL & International Multiple Sclerosis Genetics Consortium (IMSGC) 2013, 'Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis' Nature Genetics, vol 45, no. 11, pp. 1353-60. DOI: 10.1038/ng.2770 Hobart, J, Cano, S, Baron, R, Thompson, A, Schwid, S, Zajicek, J & Andrich, D 2013, 'Achieving valid patient-reported outcomes measurement: a lesson from fatigue in multiple sclerosis' Multiple Sclerosis Journal, vol 19, no. 13, pp. 1773-83. DOI: 10.1177/1352458513483378 Freeman, J, Walters, R, Ingram, W, Slade, A, Hobart, J & Zajicek, J 2013, 'Evaluating change in mobility in people with multiple sclerosis: relative responsiveness of four clinical measures' Multiple Sclerosis Journal, vol 19, no. 12, pp. 1632-9. DOI: 10.1177/1352458513482373 Zajicek, J, Ball, S, Wright, D, Vickery, J, Nunn, A, Miller, D, Gomez Cano, M, McManus, D, Mallik, S, Hobart, J & CUPID investigator group 2013, 'Effect of dronabinol on progression in progressive multiple sclerosis (CUPID): a randomised, placebo-controlled trial' Lancet Neurology, vol 12, no. 9, pp. 857-65. DOI: 10.1016/S1474-4422(13)70159-5 Mechelli, R, Umeton, R, Policano, C, Annibali, V, Coarelli, G, Ricigliano, VAG, Vittori, D, Fornasiero, A, Buscarinu, MC, International Multiple Sclerosis Genetics Consortium (IMSGC), Wellcome Trust Case Control Consortium, 2 (WTCCC2), Romano, S, Salvetti, M & Ristori, G 2013, 'A "candidate-interactome" aggregate analysis of genome-wide association data in multiple sclerosis' PLoS One, vol 8, no. 5, e63300. DOI: 10.1371/journal.pone.0063300 McGhee, DJM, Royle, PL, Thompson, PA, Wright, DE, Zajicek, JP & Counsell, CE 2013, 'A systematic review of biomarkers for disease progression in Parkinson's disease' BMC Neurology, vol 13, 35. DOI: 10.1186/1471-2377-13-35 Posner, HB, Cano, S, Carrillo, MC, Selnes, O, Stern, Y, Thomas, RG, Zajicek, J, Hobart, J & Alzheimer's Disease Neuroimaging Initiative 2013, 'Establishing the psychometric underpinning of cognition measures for clinical trials of Alzheimer's disease and its precursors: a new approach' Alzheimer's and Dementia, vol 9, no. 1 Suppl, pp. S56-60. DOI: 10.1016/j.jalz.2012.10.008 Hobart, J, Cano, S, Posner, H, Selnes, O, Stern, Y, Thomas, R, Zajicek, J & Alzheimer's Disease Neuroimaging Initiative 2013, 'Putting the Alzheimer's cognitive test to the test II: Rasch Measurement Theory' Alzheimer's and Dementia, vol 9, no. 1 Suppl, pp. S10-20. DOI: 10.1016/j.jalz.2012.08.006 Hobart, J, Cano, S, Posner, H, Selnes, O, Stern, Y, Thomas, R, Zajicek, J & Alzheimer's Disease Neuroimaging Initiative 2013, 'Putting the Alzheimer's cognitive test to the test I: traditional psychometric methods' Alzheimer's and Dementia, vol 9, no. 1 Suppl, pp. S4-9. DOI: 10.1016/j.jalz.2012.08.005 Escudero, J, Ifeachor, E, Zajicek, JP, Green, C, Shearer, J, Pearson, S & Alzheimer's Disease Neuroimaging Initiative 2013, 'Machine learning-based method for personalized and cost-effective detection of Alzheimer's disease' IEEE Transactions on Biomedical Engineering, vol 60, no. 1, pp. 164-8. DOI: 10.1109/TBME.2012.2212278 Zajicek, J 2013, 'Multiple sclerosis' Handbook of Clinical Neurology, vol 110, pp. 461-70. DOI: 10.1016/B978-0-444-52901-5.00039-3 Zeissler, ML, Eastwood, J, Oliver Hanemann, C, Zajicek, J & Carroll, C 2013, 'Δ9–TETRAHYDROCANNABINOL IS PROTECTIVE THROUGH PPARγ DEPENDENT MITOCHONDRIAL BIOGENESIS IN A CELL CULTURE MODEL OF PARKINSON'S DISEASE' Journal of Neurology, Neurosurgery & Psychiatry, vol 84, no. 11, pp. e2. DOI: 10.1136/jnnp-2013-306573.150

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