Stewart, Alan - University of St Andrews

个人简介

Alan Stewart graduated from the University of Edinburgh with a BSc(Hons) degree in Biochemistry in 1999 and a PhD in 2003. He then took up a postdoctoral fellowship at the Roslin Institute before joining the MRC Human Reproductive Sciences Unit as a Career Development Fellow in 2006. Whilst there his work focussed upon the identification of novel neuroendocrine signalling pathways. In 2009 he moved to the University of St Andrews where he was appointed to a Lectureship, then subsequently to a Senior Lectureship in Molecular Medicine. His research is focussed on metal ions and their roles in health and disease

近期论文

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Zafirovic, S, Obradovic, M, Sudar-Milovanovic, E, Jovanovic, A, Stanimirovic, J, Stewart, AJ, Pitt, SJ & Isenovic, ER 2017, '17ß-Estradiol protects against the effects of a high fat diet on cardiac glucose, lipid and nitric oxide metabolism in rats' Molecular and Cellular Endocrinology, vol 446, pp. 12-20. DOI: 10.1016/j.mce.2017.02.001 Handing, KB, Shabalin, IG, Kassaar, O, Khazaipoul, S, Blindauer, CA, Stewart, AJ, Chruszcz, M & Minor, W 2016, 'Circulatory zinc transport is controlled by distinct interdomain sites on mammalian albumins' Chemical Science, vol 7, no. 11, pp. 6635-6648. DOI: 10.1039/C6SC02267G Jovanovic, A, Sudar-Milovanovic, E, Obradovic, M, Pitt, SJ, Stewart, AJ, Zafirovic, S, Stanimirovic, J, Radak, D & Isenovic, ER 2016, 'Influence of a high-fat diet on cardiac iNOS in female rats' Current Vascular Pharmacology, vol 14. DOI: 10.2174/1570161114666161025101303 Stanimirovic, J, Obradovic, M, Jovanovic, A, Sudar-Milovanovic, E, Zafirovic, S, Pitt, SJ, Stewart, AJ & Isenovic, ER 2016, 'A high fat diet induces sex-specific differences in hepatic lipid metabolism and nitrite/nitrate in rats' Nitric Oxide, vol 54, pp. 51-59. DOI: 10.1016/j.niox.2016.02.007 Woodier, J, Rainbow, RD, Stewart, AJ & Pitt, SJ 2016, 'Response to Qian and Colvin: zinc-mediated regulation of the cardiac ryanodine receptor occurs via multiple binding sites' Journal of Biological Chemistry, vol 291, no. 8, pp. 4267. DOI: 10.1074/jbc.L115.713214 Arastoo, M, Hacker, C, Popovics, P, Lucocq, JM & Stewart, AJ 2016, 'Phospholipase C-η2 interacts with nuclear and cytoplasmic LIMK-1 during retinoic acid-stimulated neurite growth' Histochemistry and Cell Biology, vol 145, no. 2, pp. 163-173. DOI: 10.1007/s00418-015-1390-7 Blindauer, CA, Khazaipoul, S, Yu, R & Stewart, AJ 2016, 'Fatty acid-mediated inhibition of metal binding to the multi-metal site on serum albumin: implications for cardiovascular disease' Current Topics in Medicinal Chemistry, vol 16, no. 27, pp. 3021-3032. DOI: 10.2174/1568026616666160216155927 Stewart, AJ & Blindauer, CA 2015, 'The reduced Co2+-binding ability of ischaemia-modified albumin is unlikely to be because of oxidative modification of the N-terminus' Liver International, vol 35, no. 12, pp. 2622-2623. DOI: 10.1111/liv.12873 Stewart, AJ & Pitt, SJ 2015, 'Zinc controls RyR2 activity during excitation-contraction coupling' Channels, vol 9, no. 5, pp. 223-225. DOI: 10.1080/19336950.2015.1075784 Woodier, J, Rainbow, RD, Stewart, AJ & Pitt, SJ 2015, 'Intracellular zinc modulates cardiac ryanodine receptor-mediated calcium release' Journal of Biological Chemistry, vol 290, no. 28, pp. 17599-17610. DOI: 10.1074/jbc.M115.661280 Pitt, SJ & Stewart, AJ 2015, 'Examining a new role for zinc in regulating calcium release in cardiac muscle' Biochemical Society Transactions, vol 43, no. 3, pp. 359-363. DOI: 10.1042/BST20140285 Kassaar, O, Schwarz-Linek, U, Blindauer, CA & Stewart, AJ 2015, 'Plasma free fatty acid levels influence Zn2+-dependent histidine-rich glycoprotein-heparin interactions via an allosteric switch on serum albumin' Journal of Thrombosis and Haemostasis, vol 13, no. 1, pp. 101-110. DOI: 10.1111/jth.12771 Obradovic, M, Stewart, AJ, Pitt, SJ, Labudovic-Borovic, M, Sudar, E, Petrovic, V, Zafirovic, S, Maravic-Stojkovic, V, Vasic, V & Isenovic, ER 2014, 'In vivo effects of 17β-estradiol on cardiac Na+/K+-ATPase expression and activity in rat heart' Molecular and Cellular Endocrinology, vol 388, no. 1-2, pp. 58-68. DOI: 10.1016/j.mce.2014.03.005 Kassaar, O, McMahon, SA, Thompson, R, Botting, CH, Naismith, JH & Stewart, AJ 2014, 'Crystal structure of histidine-rich glycoprotein N2 domain reveals redox activity at an interdomain disulfide bridge: implications for angiogenic regulation' Blood, vol 123, no. 12, pp. 1948-1955. DOI: 10.1182/blood-2013-11-535963 Popovics, P, Lu, J, Kamil, LN, Morgan, K, Millar, RP, Schmid, R, Blindauer, CA & Stewart, AJ 2014, 'A canonical EF-loop directs Ca2+-sensitivity in phospholipase C-η2' Journal of Cellular Biochemistry, vol 115, no. 3, pp. 557–565. DOI: 10.1002/jcb.24690 Peters Jr, T & Stewart, AJ 2013, 'Albumin research in the 21st century' Biochimica et Biophysica Acta - General Subjects, vol 1830, no. 12, pp. 5351-5353. DOI: 10.1016/j.bbagen.2013.05.012 Barnett, JP, Blindauer, CA, Kassaar, O, Khazaipoul, S, Martin, EM, Sadler, PJ & Stewart, AJ 2013, 'Allosteric modulation of zinc speciation by fatty acids' Biochimica et Biophysica Acta - General Subjects, vol 1830, no. 12, pp. 5456-5464. DOI: 10.1016/j.bbagen.2013.05.028 Obradovic, M, Bjelogrlic, P, Rizzo, M, Katsiki, N, Haidara, M, Stewart, AJ, Jovanovic, A & Isenovic, ER 2013, 'Effects of obesity and estradiol on Na+/K+-ATPase and their relevance to cardiovascular disease' Journal of Endocrinology, vol 218, pp. R13-R23. DOI: 10.1530/JOE-13-0144 Popovics, P, Gray, A, Arastoo, M, Finelli, DK, Tan, AJL & Stewart, AJ 2013, 'Phospholipase C-η2 is required for retinoic acid-stimulated neurite growth' Journal of Neurochemistry, vol 124, no. 5, pp. 632-644. DOI: 10.1111/jnc.12122 Kassaar, O, Powis, SJ & Stewart, AJ 2012, The formation and Zn2+-dependence of histidine-rich glycoprotein-containing immune complexes. in LV Berhardt (ed.), Advances in Medicine and Biology. vol. 58, Nova Science Publishers, pp. 153-166. Majorek, KA, Porebski, PJ, Dayal, A, Zimmerman, MD, Jablonska, K, Stewart, AJ, Chruszcz, M & Minor, W 2012, 'Structural and immunologic characterization of bovine, horse, and rabbit serum albumins' Molecular Immunology, vol 52, no. 3-4, pp. 174-182. DOI: 10.1016/j.molimm.2012.05.011 Popovics, P & Stewart, AJ 2012, 'Phospholipase C-η activity may contribute to Alzheimer’s disease-associated calciumopathy.' Journal of Alzheimer's Disease, vol 30, pp. 737-744. DOI: 10.3233/JAD-2012-120241 Lu, J, Stewart, AJ, Sadler, PJ, Pinheiro, TJT & Blindauer, CA 2012, 'Allosteric inhibition of cobalt binding to albumin by fatty acids: Implications for the detection of myocardial ischemia' Journal of Medicinal Chemistry, vol 55, no. 9, pp. 4425-4430. DOI: 10.1021/jm3003137 Popovics, P & Stewart, AJ 2012, 'Putative roles for phospholipase C-η enzymes in neuronal Ca2+ signal modulation.' Biochemical Society Transactions, vol 40, pp. 282-286. DOI: 10.1042/BST20110622 Lu, J, Stewart, AJ, Sleep, D, Sadler, PJ, Pinheiro, TJT & Blindauer, CA 2012, 'A molecular mechanism for modulating plasma Zn speciation by fatty acids' Journal of the American Chemical Society, vol 134, no. 3, pp. 1454-1457. DOI: 10.1021/ja210496n