Sloan, Derek - University of St Andrews

个人简介

Dr Derek Sloan is a newly appointed Senior Clinical Lecturer and Consultant Infectious Diseases Physician with a joint appointment at the University of St Andrews and NHS Fife. He has previously worked extensively in southern Africa. In 2004, he was worked as a clinician at PCEA Chogoria Hospital in Kenya and supported set-up of an HIV clinic which provided comprehensive roll-out of anti-retroviral therapy for the first time in the district. From 2005-6 he was Senior Medical Officer and Tuberculosis (TB) Lead for Hlabisa sub-district in kwaZulu Natal, South Africa where the dual burden of HIV and drug-resistant TB had become a public health crisis. Subsequently, he completed a Wellcome Trust funded PhD fellowship at the University of Liverpool Institute of Global Health and Liverpool School of Tropical Medicine. His work there was on the clinical pharmacology of TB treatment, and included 2.5 years of combined clinical and academic work in Blantyre, Malawi. During that time he was also an Honorary Lecturer at the University of Malawi College of Medicine, and edited “The Clinical Book”, a practical pocket textbook of local management protocols for common adult medical conditions that still acts as a standard guide for medical students, clinical officers and doctors across the country. In 2015, he spent 3 months in Sierra Leone working as clinical lead on the UK-Med Quality Monitoring Team, supporting the NHS contribution to the Ebola Virus Disease outbreak in West Africa. His ongoing research interests are targeted towards clinical therapeutics questions of global public health significance, particularly in the treatment of tuberculosis and other infections.

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MacPherson, P, Squire, SB, Cleary , P, Davies, S, Wake, C, Dee, K, Walker, J, Farrow, S, McMaster, P, Woodhead, M, Sloan, DJ & on behalf of the North West TB Audit Steering Committee 2016, 'Equitable tuberculosis care in the North West of England: analysis of tuberculosis cohort review data' International Journal of Tuberculosis and Lung Disease, vol 20, no. 6, pp. 778-785. DOI: 10.5588/ijtld.15.0772 Barr, DA, Kamdolozi, M, Nishihara, Y, Ndhlovu, V, Khonga, M, Davies, GR & Sloan, DJ 2016, 'Serial image analysis of Mycobacterium tuberculosis colony growth reveals a persistent subpopulation in sputum during treatment of pulmonary TB' Tuberculosis, vol 98, pp. 110-115. DOI: 10.1016/j.tube.2016.03.001 Wallis, SK, Jehan, K, Woodhead, M, Cleary, P, Dee, K, Farrow, S, McMaster, P, Wake, C, Walker, J, Sloan, DJ & Squire, SB 2016, 'Health professionals' experiences of tuberculosis cohort audit in the North West of England: a qualitative study' BMJ Open, vol 6, no. 3, e010536. DOI: 10.1136/bmjopen-2015-010536 Sloan, DJ & Lewis, JM 2016, 'Management of multidrug-resistant TB: novel treatments and their expansion to low resource settings' Transactions of the Royal Society of Tropical Medicine and Hygiene, vol 110, no. 3, trv107, pp. 163-172. DOI: 10.1093/trstmh/trv107 Lewis, JM, Hine, P, Walker, J, Khoo, SH, Taegtmeyer, M, Squire, SB & Sloan, DJ 2016, 'First experience of effectiveness and safety of bedaquiline for 18 months within an optimised regimen for XDR-TB' European Respiratory Journal. DOI: 10.1183/13993003.01980-2015 Sloan, DJ & O'Dempsey, TJ 2015, 'Tuberculosis in the time of Ebola: Obstacles and opportunities' International Journal of Tuberculosis and Lung Disease, vol 19, no. 11, pp. 1269. DOI: 10.5588/ijtld.15.0776 Sloan, DJ, Mwandumba, HC, Kamdolozi, M, Shani, D, Chisale, B, Dutton, J, Khoo, SH, Allain, TJ & Davies, GR 2015, 'Vitamin D deficiency in Malawian adults with pulmonary tuberculosis: risk factors and treatment outcomes' International Journal of Tuberculosis and Lung Disease, vol 19, no. 8, pp. 904-911. DOI: 10.5588/ijtld.15.0071 Mzinza, DT, Sloan, DJ, Jambo, KC, Shani, D, Kamdolozi, M, Wilkinson, KA, Wilkinson, RJ, Davies, GR, Heyderman, RS & Mwandumba, HC 2015, 'Kinetics of Mycobacterium tuberculosis-specific IFN-γ responses and sputum bacillary clearance in HIV-infected adults during treatment of pulmonary tuberculosis' Tuberculosis, vol 95, no. 4, 1343, pp. 463-469. DOI: 10.1016/j.tube.2015.05.009 Sloan, DJ, Mwandumba, HC, Garton, NJ, Khoo, SH, Butterworth, AE, Allain, TJ, Heyderman, RS, Corbett, EL, Barer, MR & Davies, GR 2015, 'Pharmacodynamic modeling of bacillary elimination rates and detection of bacterial lipid bodies in sputum to predict and understand outcomes in treatment of pulmonary tuberculosis' Clinical Infectious Diseases, vol 61, no. 1, pp. 1-8. DOI: 10.1093/cid/civ195 Lewis, JM & Sloan, DJ 2015, 'The role of delamanid in the treatment of drug-resistant tuberculosis' Therapeutics and Clinical Risk Management, vol 11, pp. 779-791. DOI: 10.2147/TCRM.S71076 Gaskell, KM, Rothe, C, Gnanadurai, R, Goodson, P, Jassi, C, Heyderman, RS, Allain, TJ, Harrison, TS, Lalloo, DG, Sloan, DJ & Feasey, NA 2014, 'A prospective study of mortality from cryptococcal meningitis following treatment induction with 1200mg oral fluconazole in Blantyre, Malawi' PLoS One, vol 9, no. 11, e110285. DOI: 10.1371/journal.pone.0110285 Sloan, DJ & Parris, V 2014, 'Cryptococcal meningitis: Epidemiology and therapeutic options' Journal of Clinical Epidemiology, vol 6, no. 1, pp. 169-182. DOI: 10.2147/CLEP.S38850 Rothe, C, Sloan, DJ, Goodson, P, Chikafa, J, Mukaka, M, Denis, B, Harrison, T, van Oosterhout, JJ, Heyderman, RS, Lalloo, DG, Allain, T & Feasey, NA 2013, 'A Prospective Longitudinal Study of the Clinical Outcomes from Cryptococcal Meningitis following Treatment Induction with 800 mg Oral Fluconazole in Blantyre, Malawi' PLoS One, vol 8, no. 6, e67311. DOI: 10.1371/journal.pone.0067311 Sloan, DJ, Van Oosterhout, JJ, Malisita, K, Phiri, EM, Lalloo, DG, O'Hare, B & MacPherson, P 2013, 'Evidence of improving antiretroviral therapy treatment delays: an analysis of eight years of programmatic outcomes in Blantyre, Malawi' BMC Public Health, vol 13, 490. DOI: 10.1186/1471-2458-13-490 Feasey, NA, Banada, PP, Howson, W, Sloan, DJ, Mdolo, A, Boehme, C, Chipungu, GA, Allain, TJ, Heyderman, RS, Corbett, EL & Alland, D 2013, 'Evaluation of Xpert MTB/RIF for detection of tuberculosis from blood samples of HIV-infected adults confirms Mycobacterium tuberculosis bacteremia as an indicator of poor prognosis' Journal of Clinical Microbiology, vol 51, no. 7, pp. 2311-2316. DOI: 10.1128/JCM.00330-13 Sloan, DJ, Davies, GR & Khoo, SH 2013, 'New drugs and treatment regimens' Current Respiratory Medicine Reviews, vol 9, no. 3, pp. 200-210. DOI: 10.2174/1573398X113099990017 Sloan, DJ, Corbett, EL, Butterworth, AE, Mwandumba, HC, Khoo, SH, Mdolo, A, Shani, D, Kamdolozi, M, Allen, J, Mitchison, DA, Coleman, DJ & Davies, GR 2012, 'Optimizing outpatient serial sputum colony counting for studies of tuberculosis treatment in resource-poor settings' Journal of Clinical Microbiology, vol 50, no. 7, pp. 2315-20. DOI: 10.1128/JCM.00043-12 Sloan, DJ, Dedicoat, MJ & Lalloo, DG 2009, 'Treatment of cryptococcal meningitis in resource limited settings' Current Opinion in Infectious Diseases, vol 22, no. 5, pp. 455-63. DOI: 10.1097/QCO.0b013e32832fa214 Sloan, D, Dlamini, S & Dedicoat, M 2009, 'Management of cryptoccocal meningitis in resource-limited settings: a systematic review' South African Medical Journal, vol 99, no. 5, pp. 310—312. Sloan, DJ, Taegtmeyer, M, Pearce, IA, Hart, IJ, Miller, ARO & Beeching, NJ 2008, 'Cytomegalovirus retinitis in the absence of HIV or immunosuppression' British Journal of Ophthalmology, vol 18, no. 5, pp. 813-5. Sloan, DJ, Nicolson, A, Miller, ARO, Beeching, NJ & Beadsworth, MBJ 2008, 'Human immunodeficiency virus seroconversion presenting with acute inflammatory demyelinating polyneuropathy: a case report' J Med Case Reports, vol 2, pp. 370. Sloan, D, Dlamini, S, Paul, N & Dedicoat, M 2008, 'Treatment of acute cryptococcal meningitis in HIV infected adults, with an emphasis on resource-limited settings' Cochrane Database of Systematic Reviews, no. 4, pp. CD005647. DOI: 10.1002/14651858.CD005647.pub2 Sloan, DJ, Dedicoat, MJ & Lalloo, DG 2007, 'Healthcare-seeking behaviour and use of traditional healers after snakebite in Hlabisa sub-district, KwaZulu Natal' Tropical Medicine and International Health, vol 12, no. 11, pp. 1386-90. DOI: 10.1111/j.1365-3156.2007.01924.x Flynn, JN, Cannon, CA, Sloan, D, Neil, JC & Jarrett, O 1999, 'Suppression of feline immunodeficiency virus replication in vitroby a soluble factor secreted by CD8(+) T lymphocytes' Immunology, vol 96, no. 2, pp. 220-229. DOI: 10.1046/j.1365-2567.1999.00690.x