Reynolds, Paul - University of St Andrews

个人简介

I gained my PhD in 1997 from the Department of Pathology, University of Bristol, in Keith Brown’s lab. In 1998, I became a postdoctoral fellow in Dr Daniel Haber’s lab at Harvard Medical School/Massachusetts General Hospital Cancer Center, USA and then in 2003 I moved to the University of California, San Francisco in order to work with Dr Thea Tlsty investigating the epigenetic modulation of primary human mammary epithelial cells. I was appointed to a Lectureship at the University of St. Andrews in June 2007.

近期论文

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Tilston-Lunel, AM, Haley, K, Schlecht, N, Wang, Y, Chatterton, ALD, Moleirinho, SL, Watson, A, Hundal, H, Prystowsky, M, Gunn-Moore, FJ & Reynolds, PA 2016, 'Crumbs 3b promotes tight junctions in an ezrin-dependent manner in mammalian cells' Journal of Molecular Cell Biology, vol 8, no. 5, pp. 439-455. DOI: 10.1093/jmcb/MJW020 Gunn-Moore, FJ, Tilston-Lunel, AM & Reynolds, PA 2016, 'Willing to be involved in cancer' Genes, vol 7, no. 7, 37. DOI: 10.3390/genes7070037 Wang, Y, Gersten, A, Moleirinho, S, Gunn-Moore, F, Reynolds, PA & Prystowsky, M 2015, 'Fibroblasts in head neck squamous cell carcinoma associated with perineural invasion have high level nuclear Yes-Associated Protein (YAP) expression' Academic Pathology, vol 2, no. 4. DOI: 10.1177/2374289515616972 Caie, PD, Schuur, K, Oniscu, A, Mullen, P, Reynolds, PA & Harrison, DJ 2013, 'Human tissue in systems medicine' FEBS Journal, vol 280, no. 23, pp. 5949–5956. DOI: 10.1111/febs.12550 Moleirinho, S, Patrick, C, Tilston-Lunel, AM, Higginson, JR, Angus, L, Antkowiak, M, Barnett, S, Prystowsky, M, Reynolds, PA & Gunn-Moore, FJ 2013, 'Willin, an upstream component of the Hippo signaling pathway, orchestrates mammalian peripheral nerve fibroblasts' PLoS One, vol 8, no. 4, e60028. DOI: 10.1371/journal.pone.0060028 Moleirinho, S, Chang, N, Sims, A, Tilston-Lunel, AM, Angus, L, Steele, A, Boswell, V, Barnett, S, Ormandy, C, Faratian, D, Gunn-Moore, FJ & Reynolds, PA 2013, 'KIBRA Exhibits MST-independent Functional Regulation of the Hippo Signaling Pathway in Mammals' Oncogene, vol 32, no. 14, pp. 1821-1830. DOI: 10.1038/onc.2012.196 Moleirinho, S, Tilston-Lunel, AM, Angus, L, Gunn-Moore, FJ & Reynolds, PA 2013, 'The Expanding Family of FERM Proteins.' Biochemical Journal, vol 452 , no. 2, pp. 183-193 . DOI: 10.1042/BJ20121642 Giricz, O, Reynolds, PA, Ramnauth, A, Liu, C, Wang, T, Stead, L, Childs, G, Rohan, T, Shapiro, N, Fineberg, S, Kenny, P & Loudig, O 2012, 'Hsa-miR-375 Is Differentially Expressed During Breast Lobular Neoplasia And Promotes Loss Of Mammary Acinar Polarity' Journal of Pathology, vol 226, no. 1, pp. 108-119. DOI: 10.1002/path.2978 Angus, L, Moleirinho, S, Herron, LR, Sinha, A, Zhang, X, Niestrata, M, Dholakia, K, Prystowsky, M, Harvey, K, Reynolds, PA & Gunn-Moore, FJ 2012, 'Willin/FRMD6 Expression Activates the Hippo Signaling Pathway Kinases in Mammals and Antagonizes Oncogenic YAP' Oncogene, vol 31, no. 2, pp. 238-250. DOI: 10.1038/onc.2011.224 Schlecht, NF, Brandwein-Gensler , M, Smith , RV, Kawachi, N, Broughel, D, Lin, J, Keller , CE, Reynolds, PA, Gunn-Moore, FJ, Harris, T, Childs, G, Belbin, TY & Prystowsky, MB 2012, 'Cytoplasmic Ezrin and Moesin Correlate with Poor Survival in Head and Neck Squamous Cell Carcinoma' Head and Neck Pathology, vol 6, no. 2, pp. 232-43. DOI: 10.1007/s12105-011-0328-1 Dumont, N, Wilson, MB, Crawford, YG, Reynolds, PA, Sigaroudinia, M & Tlsty, TD 2008, 'Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers' Proceedings of the National Academy of Sciences of the United States of America, vol 105, no. 39, pp. 14867-14872. DOI: 10.1073/pnas.0807146105 Bean, GR, Bryson, AD, Pilie, PD, Goldenberg, V, Baker, JC, Ibarra, C, Brander, DMU, Paisie, C, Case, NR, Gauthier, M, Reynolds, PA, Dietz, E, Ostrander, J, Scott, V, Wilke, LG, Yee, L, Kimler, BF, Fabian, CJ, Zalles, CM, Broadwater, G, Tlsty, TD & Seewaldt, VL 2007, 'Morphologically Normal-Appearing Mammary Epithelial Cells Obtained from High-Risk Women Exhibit Methylation Silencing of INK4a/ARF.' Clinical Cancer Research, vol 13, pp. 6834-6841. DOI: 10.1158/1078-0432.CCR-07-0407 Reynolds, PA, Sigaroudinia, M, Zardo, G, Wilson, MB, Benton, G, Miller, C, Hong, C, Fridlyand, J, Costello, JF & Tlsty, TD 2006, 'Tumour Suppressor p16INK4A Regulates Polycomb-mediated DNA Hypermethylation in Human Mammary Epithelial Cells' Journal of Biological Chemistry, vol 281, no. 34, pp. 24790-24802. DOI: 10.1074/jbc.M604175200 Reynolds, PA, Smolen, GA, Palmer, RE, Sgroi, D, Yajnik, V, Gerald, WL & Haber, DA 2003, 'Identification of a DNA-binding site and transcriptional target for the EWS-WT1(+KTS) oncoprotein' Genes & Development, vol 17, no. 17, pp. 2094-2107. DOI: 10.1101/gad.1110703 Yajnik, V, Paulding, C, Sordella, R, McClatchey, AI, Saito, M, Wahrer, DCR, Reynolds, PA, Bell, DW, Lake, R, van den Heuvel, S, Settleman, J & Haber, DA 2003, 'DOCK4, a GTPase Activator, Is Disrupted during Tumourigenesis.' Cell, vol 112, no. 5, pp. 673-684. DOI: 10.1016/S0092-8674(03)00155-7 Vernon, EG, Malik, K, Reynolds, PA, Powlesland, R, Dallosso, AR, Jackson, S, Henthorn, K, Green, ED & Brown, KW 2003, 'The parathyroid hormone-responsive B1 gene is interrupted by a t(1;7)(q42;p15) breakpoint associated with Wilms' tumour' Oncogene, vol 22, no. 9, pp. 1371-1380. DOI: 10.1038/sj.onc.1206332 Palmer, R, Lee, S, Wong, J, Reynolds, PA, Zhang, H, Truong, V, Oliner, J, Gerald, W & Haber, D 2002, 'Induction of BAIAP3 by the EWS-WT1 chimeric fusion implicates regulated exocytosis in tumorigenesis' Cancer Cell, vol 2, no. 6, pp. 497-505. DOI: 10.1016/S1535-6108(02)00205-2 Wong, JC, Lee, SB, Bell, MD, Reynolds, PA, Fiore, E, Stamenkovic, I, Truong, V, Oliner, JD, Gerald, WG & Haber, DA 2002, 'Induction of the interleukin-2/15 receptor beta-chain by the EWS-WT1 translocation product' Oncogene, vol 21, no. 13, pp. 2009-2019. DOI: 10.1038/sj.onc.1205262 Powlesland, R, Charles, AK, Malik, KTA, Reynolds, PA, Pires, S, Boavida, M & Brown, KW 2000, 'Loss of heterozygosity at 7p in Wilms' tumour development' British Journal of Cancer, vol 82, no. 2, pp. 323-329. DOI: 10.1054/bjoc.1999.0922 Reynolds, PA, Powlesland, R, Keen, TJ, Inglehearn, C, Cunningham, AE, Green, ED & Brown, KW 1996, 'Localization of a novel t(1;7) translocation associated with Wilms' tumor predisposition and skeletal abnormalities' Genes, Chromosomes and Cancer, vol 17, no. 3, pp. 151-155. DOI: 10.1002/(SICI)1098-2264(199611)17:3<151::AID-GCC2>3.0.CO;2-3