Pitt, Samantha - University of St Andrews

个人简介

Samantha Pitt graduated from the University of York in 2002 with a BSc (Hons) degree in Biology. She then went on to complete a PhD in Cellular Physiology at the University of Cambridge graduating in 2006. Following two postdoctoral positions studying mechanisms of ion-channel regulation, one at University College London (Department of Pharmacology) and one at the University of Bristol (Department of Pharmacology) she moved to her current position as a Royal Society of Edinburgh Biomedical Fellow in the School of Medicine, University of St Andrews.

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Zafirovic, S, Obradovic, M, Sudar-Milovanovic, E, Jovanovic, A, Stanimirovic, J, Stewart, AJ, Pitt, SJ & Isenovic, ER 2017, '17ß-Estradiol protects against the effects of a high fat diet on cardiac glucose, lipid and nitric oxide metabolism in rats' Molecular and Cellular Endocrinology, vol 446, pp. 12-20. DOI: 10.1016/j.mce.2017.02.001 Jovanovic, A, Sudar-Milovanovic, E, Obradovic, M, Pitt, SJ, Stewart, AJ, Zafirovic, S, Stanimirovic, J, Radak, D & Isenovic, ER 2016, 'Influence of a high-fat diet on cardiac iNOS in female rats' Current Vascular Pharmacology, vol 14. DOI: 10.2174/1570161114666161025101303 Pitt, SJ, Reilly O'Donnell, B & Sitsapesan, R 2016, 'Exploring the biophysical evidence that mammalian two pore channels are NAADP-activated calcium-permeable channels' The Journal of Physiology, vol 594, no. 15, pp. 4171-4179. DOI: 10.1113/JP270936 Stanimirovic, J, Obradovic, M, Jovanovic, A, Sudar-Milovanovic, E, Zafirovic, S, Pitt, SJ, Stewart, AJ & Isenovic, ER 2016, 'A high fat diet induces sex-specific differences in hepatic lipid metabolism and nitrite/nitrate in rats' Nitric Oxide, vol 54, pp. 51-59. DOI: 10.1016/j.niox.2016.02.007 Woodier, J, Rainbow, RD, Stewart, AJ & Pitt, SJ 2016, 'Response to Qian and Colvin: zinc-mediated regulation of the cardiac ryanodine receptor occurs via multiple binding sites' Journal of Biological Chemistry, vol 291, no. 8, pp. 4267. DOI: 10.1074/jbc.L115.713214 Stewart, AJ & Pitt, SJ 2015, 'Zinc controls RyR2 activity during excitation-contraction coupling' Channels, vol 9, no. 5, pp. 223-225. DOI: 10.1080/19336950.2015.1075784 Woodier, J, Rainbow, RD, Stewart, AJ & Pitt, SJ 2015, 'Intracellular zinc modulates cardiac ryanodine receptor-mediated calcium release' Journal of Biological Chemistry, vol 290, no. 28, pp. 17599-17610. DOI: 10.1074/jbc.M115.661280 Pitt, SJ & Stewart, AJ 2015, 'Examining a new role for zinc in regulating calcium release in cardiac muscle' Biochemical Society Transactions, vol 43, no. 3, pp. 359-363. DOI: 10.1042/BST20140285 Robertson, G, Reilly O'Donnell, B & Pitt, SJ 2015, 'Exploring a novel role for zinc in modulation of sarcoplasmic reticulum calcium release in skeletal muscle' Physiology 2015, Cardiff, United Kingdom, 6/07/15 - 8/07/15, . Pitt, SJ, Lam, AKM, Rietdorf, K, Galione, A & Sitsapesan, R 2014, 'Reconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+' Science signaling, vol 7, no. 326, ra46. DOI: 10.1126/scisignal.2004854 Obradovic, M, Stewart, AJ, Pitt, SJ, Labudovic-Borovic, M, Sudar, E, Petrovic, V, Zafirovic, S, Maravic-Stojkovic, V, Vasic, V & Isenovic, ER 2014, 'In vivo effects of 17β-estradiol on cardiac Na+/K+-ATPase expression and activity in rat heart' Molecular and Cellular Endocrinology, vol 388, no. 1-2, pp. 58-68. DOI: 10.1016/j.mce.2014.03.005 Venturi, E, Galfre, E, O'Brien, F, Pitt, SJ, Bellamy, S, Sessions, RB & Sitsapesan, R 2014, 'FKBP12.6 activates RyR1: investigating the amino acid residues critical for channel modulation' Biophysical Journal, vol 106, no. 4, pp. 824-833. DOI: 10.1016/j.bpj.2013.12.041 Pitt, SJ, Lam, A, Galione, A & Sitsapesan, R 2014, 'TPC1 is a proton permeable channel that can be independently activated by cytosolic calcium or NAADP' Biophysical Journal, vol 106, no. 2, pp. 642A-642A. DOI: 10.1016/j.bpj.2013.11.3555 Venturi, E, Matyjaszkiewicz, A, Pitt, SJ, Tsaneva-Atanasova, K, Nishi, M, Yamazaki, D, Takeshima, H & Sitsapesan, R 2013, 'TRIC-B channels display labile gating: evidence from the TRIC-A knockout mouse model' Pflügers Archiv: European Journal of Physiology, vol 465, no. 8, pp. 1135-1148. DOI: 10.1007/s00424-013-1251-y Galfre, E, Pitt, SJ, Venturi, E, Sitsapesan, M, Zaccai, NR, Tsaneva-Atanasova, K, O'Neill, S & Sitsapesan, R 2012, 'FKBP12 activates the cardiac ryanodine receptor Ca2+-release channel and is antagonised by FKBP12.6' PLoS One, vol 7, no. 2, e31956. DOI: 10.1371/journal.pone.0031956 Venturi, E, Pitt, SJ, Galfre, E & Sitsapesan, R 2012, 'From eggs to hearts: what is the link between cyclic ADP-ribose and ryanodine receptors?' Cardiovascular Therapeutics, vol 30, no. 2, pp. 109-16. DOI: 10.1111/j.1755-5922.2010.00236.x Carter, S, Pitt, SJ, Colyer, J & Sitsapesan, R 2011, 'Ca2+-dependent phosphorylation of RyR2 can uncouple channel gating from direct cytosolic Ca2+ regulation' Journal of Membrane Biology, vol 240, no. 1, pp. 21-33. DOI: 10.1007/s00232-011-9339-9 Venturi, E, Mio, K, Nishi, M, Ogura, T, Moriya, T, Pitt, SJ, Okuda, K, Kakizawa, S, Sitsapesan, R, Sato, C & Takeshima, H 2011, 'Mitsugumin 23 forms a massive bowl-shaped assembly and cation-conducting channel.' Biochemistry, vol 50, no. 13, pp. 2623-32. DOI: 10.1021/bi1019447 Pitt, SJ, Funnell, TM, Sitsapesan, M, Venturi, E, Rietdorf, K, Ruas, M, Ganesan, A, Gosain, R, Churchill, GC, Zhu, MX, Parrington, J, Galione, A & Sitsapesan, R 2010, 'TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+' Journal of Biological Chemistry, vol 285, no. 45, pp. 35039-35046. DOI: 10.1074/jbc.M110.156927 Pitt, SJ, Park, K-H, Nishi, M, Urashima, T, Aoki, S, Yamazaki, D, Ma, J, Takeshima, H & Sitsapesan, R 2010, 'Charade of the SR K+-channel: two ion-channels, TRIC-A and TRIC-B, masquerade as a single K+-channel' Biophysical Journal, vol 99, no. 2, pp. 417-426. DOI: 10.1016/j.bpj.2010.04.051 Pitt, SJ, Sivilotti, LG & Beato, MB 2008, 'High intracellular chloride slows the decay of glycinergic currents' The Journal of Neuroscience, vol 28, no. 45, pp. 11454-11467. DOI: 10.1523/JNEUROSCI.3890-08.2008 Pitt, SJ, Martinez-Pinna, J, Barnard, EA & Mahaut-Smith, MP 2005, 'Potentiation of P2Y receptors by physiological elevations of extracellular K+ via a mechanism independent of Ca2+ influx.' Molecular Pharmacology, vol 67, no. 5, pp. 1705-13. DOI: 10.1124/mol.104.009902 Vial, C, Pitt, SJ, Roberts, JA, Rolf, MG, Mahaut-Smith, MP & Evans, RJ 2003, 'Lack of evidence for functional ADP-activated human P2X1 receptors supports a role for ATP during hemostasis and thrombosis.' Blood, vol 102, no. 10, pp. 3646-51. DOI: 10.1182/blood-2003-06-1963