Pettigrew, Kerry - University of St Andrews

个人简介

I graduated in Biomedical Sciences from University of Ulster in 2003, and obtained my PhD from Queens University Belfast in 2007; my project entailed case-control candidate gene studies to identify genetic variants influencing susceptibility to nephropathy in type 1 diabetes. Since 2007, I have conducted research on alveolar cell damage and growth (University of Birmingham), DNA methylation in acute myeloid leukaemia (Queens University Belfast) and identification of genetic variants predisposing to prostate cancer (National Cancer Institute, US), hypertension (University of Glasgow) and cognitive traits in childhood (University of St Andrews). I also spent some time as Senior Scientific Officer at the Cancer Research UK Genome Variation Laboratory Service (Leeds). In April 2015 I joined the Holden group to perform next-generation sequencing of bacterial isolates from hospital-acquired infections as part of the Molecular Epidemiology workstream of the Scottish Healthcare Associated Infection Prevention Institute (SHAIPI) consortium.

近期论文

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Pettigrew, KA, Frinton, E, Nudel, R, Chan, MTM, Thompson, P, Hayiou-Thomas, ME, Talcott, JB, Stein, J, Monaco, AP, Hulme, C, Snowling, MJ, Newbury, DF & Paracchini, S 2016, 'Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes' Journal of Neurodevelopmental Disorders, vol 8, 24. DOI: 10.1186/s11689-016-9157-6 Shore, RJ, Covill, L, Pettigrew, KA, Brandler, WA, Diaz Vazquez, R, Xu, Y, Tello, J, Talcott, JB, Newbury, DF, Stein, J, Monaco, AP & Paracchini, S 2016, 'The handedness-associated PCSK6 locus spans an intronic promoter regulating novel transcripts' Human Molecular Genetics, vol 25, no. 9, pp. 1771-1779. DOI: 10.1093/hmg/ddw047 Pettigrew, KA, Reeves, E, Leavett, R, Hayiou-Thomas, ME, Sharma, A, Simpson, NH, Martinelli, A, Thompson, P, Hulme, C, Snowling, MJ, Newbury, DF & Paracchini, S 2015, 'Copy number variation screen identifies a rare de novo deletion at chromosome 15q13.1-13.3 in a child with language impairment' PLoS One, vol 10, no. 8, e0134997. DOI: 10.1371%2Fjournal.pone.0134997 Pettigrew, KA, Fajutrao Valles, SF, Moll, K, Northstone, K, Ring, S, Pennell, C, Wang, C, Leavett, R, Hayiou-Thomas, ME, Thompson, P, Simpson, NH, Fisher, SE, Whitehouse, AJO, Snowling, MJ, Newbury, DF, Paracchini, S & SLI Consortium 2015, 'Lack of replication for the myosin-18B association with mathematical ability in independent cohorts' Genes, Brain and Behavior, vol 14, no. 4, pp. 369-376. DOI: 10.1111/gbb.12213 Dellett, M, Colyer, HAA, Pettigrew, KA, McMullin, M-F, Rea, IM & Mills, K 2013, 'Altered methylation levels in elderly acute myeloid leukaemia patients compared to elderly well individuals' British Journal of Haematology. Pettigrew, KA, Armstrong, R, Colyer, H, Zhang, S-D, Rea, IM, Jones, R, Baird, D & Mills, K 2012, 'Differential TERT promoter methylation and response to 5-aza-2'-deoxycytidine in acute myeloid leukemia cell lines: TERT expression, telomerase activity, telomere length, and cell death.' Genes, Chromosomes and Cancer, vol 51, no. 8, 51(8), pp. 768-780. DOI: 10.1002/gcc.21962 Jeemon, P, Pettigrew, K, Sainsbury, C, Prabhakaran, D & Padmanabhan, S 2011, 'Implications of discoveries from genome-wide association studies in current cardiovascular practice' World Journal of Cardiology, vol 3, no. 7, pp. 230-47. DOI: 10.4330/wjc.v3.i7.230 Parikh, H, Wang, Z, Pettigrew, KA, Jia, J, Daugherty, S, Yeager, M, Jacobs, KB, Hutchinson, A, Burdett, L, Cullen, M, Qi, L, Boland, J, Collins, I, Albert, TJ, Vatten, LJ, Hveem, K, Njolstad, I, Cancel-Tassin, G, Cussenot, O, Valeri, A, Virtamo, J, Thun, MJ, Feigelson, HS, Diver, WR, Chatterjee, N, Thomas, G, Albanes, D, Chanock, SJ, Hunter, DJ, Hoover, R, Hayes, RB, Berndt, SI, Sampson, J & Amundadottir, L 2011, 'Fine mapping the KLK3 locus on chromosome 19q13.33 associated with prostate cancer susceptibility and PSA levels' Human Genetics, vol 129, no. 6, pp. 675-685. DOI: 10.1007/s00439-011-0953-5 McKnight, AJ, Pettigrew, KA, Patterson, CC, Kilner, J, Sadlier, DM, Maxwell, AP & Warren 3 UK GoKinD Study Grp 2010, 'Investigation of the association of BMP gene variants with nephropathy in Type 1 diabetes mellitus' Diabetic Medicine, vol 27, no. 6, pp. 624-630. DOI: 10.1111/j.1464-5491.2010.02976.x McKnight, AJ, Patterson, CC, Pettigrew, KA, Savage, DA, Kilner, J, Murphy, M, Sadlier, D, Maxwell, AP & Warren 3 UK Genetics Kidneys Diab 2010, 'A GREM1 Gene Variant Associates with Diabetic Nephropathy' Journal of the American Society of Nephrology, vol 21, no. 5, pp. 773-781. DOI: 10.1681/ASN.2009070773 Pettigrew, KA, McKnight, AJ, Patterson, CC, Kilner, J, Sadlier, DM & Maxwell, AP 2010, 'Resequencing of the CCL5 and CCR5 genes and investigation of variants for association with diabetic nephropathy' Journal of Human Genetics, vol 55, no. 4, pp. 248-251. DOI: 10.1038/jhg.2010.15 McKnight, AJ, Woodman, AM, Parkkonen, M, Patterson, CC, Savage, DA, Forsblom, C, Pettigrew, KA, Sadlier, D, Groop, PH, Maxwell, AP & Warren 3 UK GoKinD Study Grp 2009, 'Investigation of DNA polymorphisms in SMAD genes for genetic predisposition to diabetic nephropathy in patients with type 1 diabetes mellitus' Diabetologia, vol 52, no. 5, pp. 844-849. DOI: 10.1007/s00125-009-1281-3 Pettigrew, KA, McKnight, AJ, Martin, RJ, Patterson, CC, Kilner, J, Sadlier, D, Maxwell, AP, Savage, DA & Warren 3 K GoKinD Study Grp 2008, 'No support for association of protein kinase C, beta 1 (PRKCB1) gene promoter polymorphisms c.-1504C > T and c.-546C > G with diabetic nephropathy in Type 1 diabetes' Diabetic Medicine, vol 25, no. 9, pp. 1127-1129. DOI: 10.1111/j.1464-5491.2008.02540.x Pettigrew, K, Rathinam, S, Rajesh, P, Gao, F, Tetley, T & Thickett, DR 2007, 'Vascular endothelial growth factor receptor ligation differentially regulates primary human alveolar type II cell repair responses and is anti-apoptotic for sFasL but not 0.03% H2O2 induced cell death' Thorax, vol 62, pp. A2-A2. Mckeown, ST, O'Kane, CM, Perkins, GD, Pettigrew, K, Gao, F, Thickett, DR & Mcauley, DF 2007, 'Salbutamol drives upregulated MMP-9 activity in the alveolar space in acute respiratory distress syndrome' Thorax, vol 62, pp. A63-A63. Perkins, G, Pettigrew, K, Rathinam, S, Rajesh, P, Gao, F, Hughes, S, Bassford, C, Stewart, PM & Thickett, D 2007, 'Aberrant local steroid metabolism and its modulation by intravenous salbutamol in patients with acute respiratory distress syndrome' Thorax, vol 62, pp. A113-A114. Roberts, JR, Perkins, GD, Fujisawa, T, Pettigrew, KA, Gao, F, Ahmed, A & Thickett, DR 2007, 'Vascular endothelial growth factor promotes physical wound repair and is anti-apoptotic in primary distal lung epithelial and A549 cells' Critical Care Medicine, vol 35, no. 9, pp. 2164-2170. DOI: 10.1097/01.CCM.0000281451.73202.F6