Cox-Singh, Janet - University of St Andrews

个人简介

In 1999 JCS moved to University Malaysia Sarawak (UNIMAS), Malaysian Borneo where the entry of P. knowlesi was discovered. Naturally acquired P. knowlesi malaria was new. The UNIMAS team produced the first clinical descriptions of knowlesi malaria and soon discovered severe and fatal infections. In 2008 JCS returned to the UK as a Senior Research Fellow, St George’s, University of London, to address the question: Why do only some people infected with P. knowlesi develop severe disease? In 2012 Janet Cox-Singh accepted a Senior Lectureship in infection, University of St Andrews, Scotland where she continues her research on P. knowlesi and the pathobiology of severe malaria

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Millar, SB & Cox Singh, J 2015, 'Human infections with Plasmodium knowlesi - zoonotic malaria' Clinical Microbiology and Infection, vol 21, no. 7, pp. 640-648. DOI: 10.1016/j.cmi.2015.03.017 Cox Singh, J & Culleton, R 2015, 'Plasmodium knowlesi: from severe zoonosis to animal model' Trends in Parasitology, vol 31, no. 6. DOI: 10.1016/j.pt.2015.03.003 Monsanto Pinheiro, M, Ahmed, MA, Millar, SB, Sanderson, T, Otto, TD, Lu, WC, Krishna, S, Rayner, JC & Cox Singh, J 2015, 'Plasmodium knowlesi genome sequences from clinical isolates reveal extensive genomic dimorphism' PLoS One, vol 10, no. 4, e0121303. DOI: 10.1371/journal.pone.0121303 Ahmed, MA & Cox Singh, J 2015, 'Plasmodium knowlesi – an emerging pathogen' ISBT Science Series, vol 10, no. S1, pp. 134-140. DOI: 10.1111/voxs.12115 Ahmed, AM, Monsanto Pinheiro, M, Divis, PC, Siner, A, Zainudin, R, Wong, IT, Lu, CW, Singh-Khaira, SK, Millar, SB, Lynch, S, Willmann, M, Singh, B, Krishna, S & Cox Singh, J 2014, 'Disease progression in Plasmodium knowlesi malaria is linked to variation in invasion gene family members' PLoS Neglected Tropical Diseases, vol 8, no. 8, e3086. DOI: 10.1371/journal.pntd.0003086 Foster, D, Cox Singh, J, Mohamad, DSA, Krishna, S, Chin, PP & Singh, B 2014, 'Evaluation of three rapid diagnostic tests for the detection of human infections with Plasmodium knowlesi' Malaria Journal, vol 13, 60. DOI: 10.1186/1475-2875-13-60 Fatih, FA, Staines, HM, Siner, A, Ahmed, MA, Woon, LC, Pasini, EM, Kocken, CHM, Singh, B, Cox Singh, J & Krishna, S 2013, 'Susceptibility of human plasmodium knowlesi infections to anti-malarials' Malaria Journal, vol 12, 425. DOI: 10.1186/1475-2875-12-425 Willmann, M, Ahmed, A, Siner, A, Wong, IT, Woon, LC, Singh, B, Krishna, S & Cox Singh, J 2012, 'Laboratory markers of disease severity in Plasmodium knowlesi infection: a case control study' Malaria Journal, vol 11, no. 363, 363. DOI: 10.1186/1475-2875-11-363 Fatih, FA, Siner, A, Ahmed, A, Woon, LC, Craig, AG, Singh, B, Krishna, S & Cox Singh, J 2012, 'Cytoadherence and virulence - the case of Plasmodium knowlesi malaria' Malaria Journal, vol 11, 33. DOI: 10.1186/1475-2875-11-33 Cox-Singh, J, Singh, B, Daneshvar, C, Planche, T, Parker-Williams, J, Krishna, S & Cox Singh, J 2011, 'Anti-inflammatory cytokines predominate in acute human Plasmodium knowlesi infections' PLoS One, vol 6, no. 6, e20541. DOI: 10.1371/journal.pone.0020541 Lee, K-S, Divis, PCS, Zakaria, SK, Matusop, A, Julin, RA, Conway, DJ, Cox Singh, J & Singh, B 2011, 'Plasmodium knowlesi: reservoir hosts and tracking the emergence in humans and macaques' PLoS Pathogens, vol 7, no. 4, e1002015. DOI: 10.1371/journal.ppat.1002015 Daneshvar, C, Davis, TME, Cox Singh, J, Rafa'ee, MZ, Zakaria, SK, Divis, PCS & Singh, B 2010, 'Clinical and parasitological response to oral chloroquine and primaquine in uncomplicated human Plasmodium knowlesi infections' Malaria Journal, vol 9, 238. DOI: 10.1186/1475-2875-9-238 Cox-Singh, J & Cox Singh, J 2010, 'Malaria: what can apes teach humans?' Future Microbiology, vol 5, no. 8, pp. 1157-1160. DOI: 10.2217/FMB.10.86 Ahouidi, AD, Bei, AK, Neafsey, DE, Sarr, O, Volkman, S, Milner, D, Cox-Singh, J, Ferreira, MU, Ndir, O, Premji, Z, Mboup, S, Duraisingh, MT & Cox Singh, J 2010, 'Population genetic analysis of large sequence polymorphisms in Plasmodium falciparum blood-stage antigens' Infection Genetics and Evolution, vol 10, no. 2, pp. 200-206. DOI: 10.1016/j.meegid.2009.11.008 Cox Singh, J, Hiu, J, Lucas, SB, Divis, PC, Zulkarnaen, M, Chandran, P, Wong, KT, Adem, P, Zaki, SR, Singh, B & Krishna, S 2010, 'Severe malaria - a case of fatal Plasmodium knowlesi infection with post-mortem findings: a case report' Malaria Journal, vol 9, 10. DOI: 10.1186/1475-2875-9-10 Cox Singh, J 2009, 'Knowlesi malaria in Vietnam' Malaria Journal, vol 8, 269. DOI: 10.1186/1475-2875-8-269 Daneshvar, C, Davis, TME, Cox Singh, J, Rafa'ee, MZ, Zakaria, SK, Divis, PCS & Singh, B 2009, 'Clinical and Laboratory Features of Human Plasmodium knowlesi Infection' Clinical Infectious Diseases, vol 49, no. 6, pp. 852-860. DOI: 10.1086/605439 Lee, K-S, Cox Singh, J, Brooke, G, Matusop, A & Singh, B 2009, 'Plasmodium knowlesi from archival blood films: Further evidence that human infections are widely distributed and not newly emergent in Malaysian Borneo' International Journal for Parasitology, vol 39, no. 10, pp. 1125-1128. DOI: 10.1016/j.ijpara.2009.03.003 Lee, K-S, Cox Singh, J & Singh, B 2009, 'Morphological features and differential counts of Plasmodium knowlesi parasites in naturally acquired human infections' Malaria Journal, vol 8, 73. DOI: 10.1186/1475-2875-8-73 Myers, WP, Myers, AP, Cox Singh, J, Lau, HC, Mokuai, B & Malley, R 2009, 'Micro-geographic risk factors for malarial infection' Malaria Journal, vol 8, 27. DOI: 10.1186/1475-2875-8-27 Siner, A, Ahmad, FB, Davis, TM, Singh, B, Cox-Singh, J & Cox Singh, J 2008, 'IN VITRO ACTIVITY OF A DICHLOROMETHANE FRACTION OF LANSIUM DOMESTICUM LEAVES AGAINST PLASMODIUM FALCIPARUM CLONE 3D7' American Journal of Tropical Medicine and Hygiene, vol 79, no. 6, pp. 278-278. Cox-Singh, J, Singh, B & Cox Singh, J 2008, 'Knowlesi malaria: newly emergent and of public health importance?' Trends in Parasitology, vol 24, no. 9, pp. 406-410. DOI: 10.1016/j.pt.2008.06.001 Cox Singh, J, Davis, TME, Lee, K-S, Shamsul, SSG, Matusop, A, Ratnam, S, Rahman, HA, Conway, DJ & Singh, B 2008, 'Plasmodium knowlesi malaria in humans is widely distributed and potentially life threatening' Clinical Infectious Diseases, vol 46, no. 2, pp. 165-171. DOI: 10.1086/524888 Thapa, S, Hollander, J, Linehan, M, Cox-Singh, J, Bista, MB, Thakur, GD, Davis, WA, Davis, TME & Cox Singh, J 2007, 'Comparison of artemether-lumefantrine with sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in eastern Nepal' American Journal of Tropical Medicine and Hygiene, vol 77, no. 3, pp. 423-430. Anthony, TG, Conway, DJ, Cox-Singh, J, Matusop, A, Ratnam, S, Shamsul, S, Singh, B & Cox Singh, J 2005, 'Fragmented population structure of Plasmodium falciparum in a region of declining endemicity' Journal of Infectious Diseases, vol 191, no. 9, pp. 1558-1564.