Scott, Pamela - University of Glasgow - School of Life Sciences

研究领域

My lab is investigating the mechanisms responsible for controlling the rise in RNA polymerase III transcription that occurs following growth factor stimulation of mammalian cells

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Goodfellow, S.J., Innes, F., Derblay, L.E., MacLellan, W.R., Scott, P., and White, R.J. (2006) Regulation of RNA polymerase III transcription during hypertrophic growth. EMBO Journal, 25(7), pp. 1522-1533. (doi:10.1038/sj.emboj.7601040) Ernens, I., Goodfellow, S., Innes, F., Kenneth, N., Derblay, L., White, R., and Scott, P. (2006) Hypoxic stress suppresses RNA polymerase III recruitment and tRNA gene transcription in cardiomyocytes. Nucleic Acids Research, 34, pp. 286-294. (doi:10.1093/nar/gkj402) Welsh, D., Scott, P., and Peacock, A. (2006) p38 MAP kinase isoform activity and cell cycle regulators in the proliferative response of pulmonary and systemic artery fibroblasts to acute hypoxia. Pulmonary Pharmacology and Therapeutics, 19, pp. 128-138. (doi:10.1016/j.pupt.2005.04.008) Mauger, E., and Scott, P. (2004) Mitogenic stimulation of transcription by RNA polymerase III. Biochemical Society Transactions, 32, pp. 976-977. Buxbaum, L., Denise, H., Coombs, G., Alexander, J., Mottram, J., and Scott, P. (2003) Cysteine protease B of Leishmania mexicana inhibits host Th1 responses and protective immunity. Journal of Immunology, 171, pp. 3711-3717. Fairley, J.A., Scott, P.H., and White, R.J. (2003) TFIIIB is phosphorylated, disrupted and selectively released from tRNA promoters during mitosis in vivo. EMBO Journal, 22, pp. 5841-5850. Felton-Edkins, Z.A., Fairley, J.A., Graham, E.L., Johnston, I.M., White, R.J., and Scott, P.H. (2003) The mitogen-activated protein (MAP) kinase ERK induces tRNA synthesis by phosphorylating TFIIIB. EMBO Journal, 22, pp. 2422-2432. Pollock, K., Mcneil, K., Mottram, J., Lyons, R., Brewer, J., Scott, P., Coombs, G., and Alexander, J. (2003) The Leishmania mexicana cysteine protease, CPB2.8, induces potent Th2 responses. Journal of Immunology, 170, pp. 1746-1753. Johnston, I., Allison, S., Morton, J., Schramm, L., Scott, P., and White, R. (2002) CK2 forms a stable complex with TFIII3 and activates RNA polymerase III transcription in human cells. Molecular and Cellular Biology, 22, pp. 3757-3768. (doi:10.1128/MCB.22.11.3757-3768.2002) Woods, C., Mutrie, N., Scott, P., and Simpson, C. (2002) An examination of the relationship between physical activity stage of change and body weight in young men and women. Journal of Sports Sciences, 20, pp. 44-45. Ciarmatori, S., Scott, P., Sutcliffe, J., McLees, A., Alzuherri, H., Dannenberg, J., te Riele, H., Grummt, I., Voit, R., and White, R. (2001) Overlapping functions of the pRb family in the regulation of rRNA synthesis. Molecular and Cellular Biology, 21, pp. 5806-5814. Scott, P.H., Cairns, C.A., Sutcliffe, J.E., Alzuherri, H.M., McLees, A., Winter, A.G., and White, R.J. (2001) Regulation of RNA polymerase III transcription during cell cycle entry. Journal of Biological Chemistry, 276(2), pp. 1005-1014. (doi:10.1074/jbc.M005417200 )