Kennedy, Simon - University of Glasgow - School of Life Sciences

个人简介

Simon Kennedy is a Senior Lecturer at Glasgow University and has been involved in developing and using in vivo animal models of balloon injury and stenting for around 15years. He has published widely using these models to investigate mechanisms of cardiovascular pathophysiology. He has chaired symposia at local and international meetings and organized several specialized meetings on in vivo research. He is on the editorial board of the British Journal of Pharmacology and the review journal Pharmacology & Therapeutics and is a member of the British Pharmacological Society meetings committee. His work is supported by the British Heart Foundation, Medical Research Council and the EPSRC. His laboratory is one of the few in Europe which uses the pig model of coronary stenting

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Kennedy, S. (2017) Changes in IP3 receptor expression and function in aortic smooth muscle of atherosclerotic mice. Journal of Vascular Research, (Accepted for Publication) Houston, S. A., Ugusman, A., Gnanadesika, S., and Kennedy, S. (2016) An investigation of the antiplatelet effects of succinobucol (AGI-1067). Platelets, (doi:10.1080/09537104.2016.1218456) (PMID:27681689) (Early Online Publication) Almabrouk, T. A.M., Ugusman, A. B., Katwan, O. J., Salt, I. P., and Kennedy, S. (2016) Deletion of AMPKα1 attenuates the anticontractile effect of perivascular adipose tissue (PVAT) and reduces adiponectin release. British Journal of Pharmacology, (doi:10.1111/bph.13633) (PMID:27668984) (Early Online Publication) MacRitchie, N., Volpert, G., Al Washih, M., Watson, D. G., Futerman, A. H., Kennedy, S., Pyne, S., and Pyne, N. J. (2016) Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension. Cellular Signalling, 28(8), pp. 946-955. (doi:10.1016/j.cellsig.2016.03.014) (PMID:27063355) (PMCID:PMC4913619) McCormick, C., Jones, R. L., Wadsworth, R. M., Mullen, A. B., and Kennedy, S. (2016) A polymer coated cicaprost-eluting stent increases neointima formation and impairs vessel function in the rabbit iliac artery. Pharmacology and Pharmacy, 7(6), pp. 226-235. (doi:10.4236/pp.2016.76029) McKittrick, C.M., Kennedy, S., Oldroyd, K.G., Mcginty, S., and McCormick, C. (2016) Modelling the impact of atherosclerosis on drug release and distribution from coronary stents. Annals of Biomedical Engineering, 44(2), pp. 477-487. (doi:10.1007/s10439-015-1456-7) (PMID:26384667) (PMCID:PMC4764635) Watt, J., Kennedy, S., Ahmed, N., Hayhurst, J., McClure, J. D., Berry, C., Wadsworth, R. M., and Oldroyd, K. G. (2016) The relationship between oxidised LDL, endothelial progenitor cells and coronary endothelial function in patients with CHD. Open Heart, 3(1), e000342. (doi:10.1136/openhrt-2015-000342) (PMID:26848395) (PMCID:PMC4731840) Greig, F. H., Ewart, M.-A., McNaughton, E., Cooney, J., Spickett, C. M., and Kennedy, S. (2015) The hypotensive effect of acute and chronic AMP-activated protein kinase activation in normal and hyperlipidemic mice. Vascular Pharmacology, 74, pp. 93-102. (doi:10.1016/j.vph.2015.07.010) (PMID:26196300) (PMCID:PMC4673085) Wu, J., Grassia, G., Cambrook, H., Ialenti, A., MacRitchie, N., Carberry, J., Wadsworth, R. M., Lawrence, C., Kennedy, S., and Maffia, P. (2015) Perivascular mast cells regulate vein graft neointimal formation and remodeling. PeerJ, 3, e1192. (doi:10.7717/peerj.1192) (PMID:26312183) (PMCID:PMC4548472) Mckinney, C.A., Kennedy, S., Baillie, G.S., Milligan, G., and Nicklin, S.A. (2015) Angiotensin-(1-7) and angiotensin-(1-9) inhibit vascular smooth muscle cell growth and migration in vitro and vascular remodelling in vivo. Atherosclerosis, 241(1), e44. (doi:10.1016/j.atherosclerosis.2015.04.158) McDonald, R. A. et al. (2015) Reducing in-stent restenosis therapeutic manipulation of miRNA in vascular remodeling and inflammation. Journal of the American College of Cardiology, 65(21), pp. 2314-2327. (doi:10.1016/j.jacc.2015.03.549) (PMID:26022821) (PMCID:PMC4444526) Greig, F. H., Hutchison, L., Spickett, C. M., and Kennedy, S. (2015) Differential effects of chlorinated and oxidized phospholipids in vascular tissue: implications for neointima formation. Clinical Science, 128, pp. 579-592. (doi:10.1042/CS20140578) (PMID:25524654) Farmer, D. G.S., Ewart, M.-A., Mair, K. M., and Kennedy, S. (2014) Soluble receptor for advanced glycation end products (sRAGE) attenuates haemodynamic changes to chronic hypoxia in the mouse. Pulmonary Pharmacology and Therapeutics, 29(1), pp. 7-14. (doi:10.1016/j.pupt.2014.01.002) Ewart, M.-A., Kennedy, S., MacMillan, D., Raja, A. L.N., Watt, I. M., and Currie, S. (2014) Altered vascular smooth muscle function in the ApoE knockout mouse during the progression of atherosclerosis. Atherosclerosis, 234(1), pp. 154-161. (doi:10.1016/j.atherosclerosis.2014.02.014) Almabrouk, T.A.M., Ewart, M.-A., Salt, I.P., and Kennedy, S. (2014) Perivascular fat, AMP-activated protein kinase and vascular diseases. British Journal of Pharmacology, 171(3), pp. 595-617. (doi:10.1111/bph.12479) (PMID:24490856) (PMCID:PMC3969075) McDonald, R. A. et al. (2013) miRNA-21 is dysregulated in response to vein grafting in multiple models and genetic ablation in mice attenuates neointima formation. European Heart Journal, 34(22), pp. 1636-1643. (doi:10.1093/eurheartj/eht105) Kennedy, S., Wu, J., Wadsworth, R.M., Lawrence, C.E., and Maffia, P. (2013) Mast cells and vascular diseases. Pharmacology and Therapeutics, 138(1), pp. 53-65. (doi:10.1016/j.pharmthera.2013.01.001) Watt, J., Kennedy, S., McCormick, C., Agbani, E.O., McPhaden, A., Mullen, A., Czudaj, P., Behnisch, B., Wadsworth, R.M., and Oldroyd, K.G. (2013) Succinobucol-eluting stents increase neointimal thickening and peri-strut inflammation in a porcine coronary model. Catheterization and Cardiovascular Interventions, 81(4), pp. 698-708. (doi:10.1002/ccd.24473) Ewart, M.-A., and Kennedy, S. (2012) Diabetic cardiovascular disease AMP-activated protein kinase (AMPK) as a therapeutic target. Cardiovascular and Hematological Agents in Medicinal Chemistry, 10(3), pp. 190-211. (doi:10.2174/187152512802651015) Watt, J., Ewart, M.-A., Greig, F. H., Oldroyd, K. G., Wadsworth, R. M., and Kennedy, S. (2012) The effect of reactive oxygen species on whole blood aggregation and the endothelial cell-platelet interaction in patients with coronary heart disease. Thrombosis Research, 130(2), pp. 210-215. (doi:10.1016/j.thromres.2012.03.024) Greig, F. H., Kennedy, S., and Spickett, C. M. (2012) Physiological effects of oxidized phospholipids and their cellular signaling mechanisms in inflammation. Free Radical Biology and Medicine, 52(2), pp. 266-280. (doi:10.1016/j.freeradbiomed.2011.10.481) Watt, J., Ewart, M.-A., Greig, F.H., Oldroyd, K.G., Wadsworth, R.M., and Kennedy, S. (2012) The effect of reactive oxygen species on whole blood aggregation and the enothelial cell-platelet interaction in patients with coronary heart disease. Thrombosis Research, 130(2), pp. 210-215. (doi:10.1016/j.thromres.2012.03.024) Ialenti, A. et al. (2011) Inhibition of in-stent stenosis by oral administration of bindarit in porcine coronary arteries. Arteriosclerosis, Thrombosis, and Vascular Biology, 31(11), pp. 2448-2454. (doi:10.1161/ATVBAHA.111.230078) (PMID:21852559) Ewart, M.-A., and Kennedy, S. (2011) AMPK and vasculoprotection. Pharmacology and Therapeutics, 131(2), pp. 242-253. (doi:10.1016/j.pharmthera.2010.11.002) Wu, J., Wadsworth, R.M., and Kennedy, S. (2011) Inhibition of inducible Nitric Oxide synthase promotes vein graft neoadventitial inflammation and remodelling. Journal of Vascular Research, 48(2), pp. 141-149. (doi:10.1159/000316968)