Kemi, Ole - University of Glasgow - School of Life Sciences

研究领域

Cell biology and molecular physiology of the heart and muscle. We study the cardiac, skeletal, and vascular muscle under normal conditions, during pathological conditions such as myocardial infarction, heart failure, and cardiac myopathies, and after exercise training in both health and disease. This includes studying the cellular and molecular mechanistic events that underlie and translate into improved function and clinical outcome in health and disease, with the use of experimental exercise and disease models and biophysical, biochemical, molecular, physiology, and pharmacological methods

近期论文

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H?ydal, M. A. et al. (2016) Exercise training reverses myocardial dysfunction induced by CaMKIIδC overexpression by restoring Ca2+-homeostasis. Journal of Applied Physiology, 121(1), pp. 212-220. (doi:10.1152/japplphysiol.00188.2016) (PMID:27231311) Wisl?ff, U., Bye, A., St?len, T., Kemi, O. J., Pollott, G. E., Pande, M., McEachin, R. C., Britton, S. L., and Koch, L. G. (2015) Blunted cardiomyocyte remodeling response in exercise-resistant rats. Journal of the American College of Cardiology, 65(13), pp. 1378-1380. (doi:10.1016/j.jacc.2015.01.041) (PMID:25835453) Ghouri, I. A., Kelly, A., Burton, F. L., Smith, G. L., and Kemi, O. J. (2015) 2-photon excitation fluorescence microscopy enables deeper high-resolution imaging of voltage and Ca2+in intact mice, rat, and rabbit hearts. Journal of Biophotonics, 8(1-2), pp. 112-123. (doi:10.1002/jbio.201300109) Devlin, J., Paton, B., Poole, L., Sun, W., Ferguson, C., Wilson, J., and Kemi, O. J. (2014) Blood lactate clearance after maximal exercise depends on active recovery intensity. Journal of Sports Medicine and Physical Fitness, 54(3), pp. 271-278. Kemi, O.J., Haram, P.M., H?ydal, M.A., Wisl?ff, U., and Ellingsen, ?. (2013) Exercise training and losartan improve endothelial function in heart failure rats by different mechanisms. Scandinavian Cardiovascular Journal, 47(3), pp. 160-167. (doi:10.3109/14017431.2012.754935) Ferguson, C., Wilson, J., Birch, K.M., and Kemi, O.J. (2013) Application of the speed-duration relationship to normalize the intensity of high-intensity interval training. PLoS ONE, 8(11), e76420. (doi:10.1371/journal.pone.0076420) Kelly, A., Ghouri, I.A., Kemi, O.J., Bishop, M.J., Bernus, O., Fenton, F.H., Myles, R.C., Burton, F.L., and Smith, G.L. (2013) Subepicardial action potential characteristics are a function of depth and activation sequence in isolated rabbit hearts. Circulation: Arrhythmia and Electrophysiology, 6(4), pp. 809-817. (doi:10.1161/CIRCEP.113.000334) Kaurstad, G., Alves, M. N., Kemi, O. J., Rolim, N., H?ydal, M. A., Wisl?ff, H., St?len, T. O., and Wisl?ff, U. (2012) Chronic CaMKII inhibition blunts the cardiac contractile response to exercise training. European Journal of Applied Physiology, 112(2), pp. 579-588. (doi:10.1007/s00421-011-1994-0) Kemi, O. J., MacQuaide, N., Hoydal, M. A., Ellingsen, O., Smith, G. L., and Wisloff, U. (2012) Exercise training corrects control of spontaneous calcium waves in hearts from myocardial infarction heart failure rats. Journal of Cellular Physiology, 227(1), pp. 20-26. (doi:10.1002/jcp.22771) Koch, L. G. et al. (2011) Intrinsic aerobic capacity sets a divide for aging and longevity. Circulation Research, 109(10), pp. 1162-1172. (doi:10.1161/CIRCRESAHA.111.253807) Kemi, O. J., Hoydal, M. A., MacQuaide, N., Haram, P. M., Koch, L. G., Britton, S. L., Ellingsen, O., Smith, G. L., and Wisloff, U. (2011) The effect of exercise training on transverse tubules in normal, remodeled, and reverse remodeled hearts. Journal of Cellular Physiology, 226(9), pp. 2235-2243. (doi:10.1002/jcp.22559) Helgerud, J., Rodas, G., Kemi, O.J., and Hoff, J. (2011) Strength and endurance in elite football players. International Journal of Sports Medicine, 32(9), pp. 677-682. (doi:10.1055/s-0031-1275742) Kemi, O.J., Rognmo, O., Amundsen, B.H., Stordahl, S., Richardson, R.S., Helgerud, J., and Hoff, J. (2011) One-arm maximal strength training improves work economy and endurance capacity but not skeletal muscle blood flow. Journal of Sports Sciences, 29(2), pp. 161-170. (doi:10.1080/02640414.2010.529454) Kemi, O.J., and Wisl?ff, U. (2010) Mechanisms of exercise-induced improvements in the contractile apparatus of the mammalian myocardium. Acta Physiologica, 199(4), pp. 425-439. (doi:10.1111/j.1748-1716.2010.02132.x) Menzies, P., Menzies, C., McIntyre, L., Paterson, P., Wilson, J., and Kemi, O.J. (2010) Blood lactate clearance during active recovery after an intense running bout depends on the intensity of the active recovery. Journal of Sports Sciences, 28(9), pp. 975-982. (doi:10.1080/02640414.2010.481721) Kemi, O. J., and Wisl?ff, U. (2010) High-intensity aerobic exercise training improves the heart in health and disease. Journal of Cardiopulmonary Rehabilitation and Prevention, 30(1), pp. 2-11. (doi:10.1097/HCR.0b013e3181c56b89) (PMID:20040880) Smith, G., Reynolds, M., Burton, F.L., and Kemi, O.J. (2010) Confocal and multiphoton imaging of intracellular Ca2+. Methods in Cell Biology, 99(10), pp. 255-261. (doi:10.1016/B978-0-12-374841-6.00009-8) Wang, Y., Wisloff, U., and Kemi, O.J. (2010) Animal models in the study of exercise-induced cardiac hypertrophy. Physiological Research, 59(5), pp. 633-644. Wisloff, U., Ellingsen, O., and Kemi, O.J. (2009) High-intensity interval training to maximize cardiac benefits of exercise training? Exercise and Sport Sciences Reviews, 37(3), pp. 139-146. (doi:10.1097/JES.0b013e3181aa65fc) Kemi, O.J. (2009) Experimental evidence may inform the debate. Journal of Applied Physiology, 106(1), p. 345. Haram, P.M. et al. (2009) Aerobic interval training vs. continuous moderate exercise in the metabolic syndrome of rats artificially selected for low aerobic capacity. Cardiovascular Research, 81(4), pp. 723-732. (doi:10.1093/cvr/cvn332) St?len, T.O. et al. (2009) Interval training normalizes cCardiomyocyte function, diastolic Ca2+ control, and SR Ca2+ release synchronicity in a mouse model of diabetic cardiomyopathy. Circulation Research, 105(6), pp. 527-536. (doi:10.1161/CIRCRESAHA.109.199810) Bye, A., Hoydal, M.A., Catalucci, D., Langaas, M., Kemi, O.J., Beisvag, V., Koch, L.G., Britton, S.L., Ellingsen, O., and Wisloff, U. (2008) Gene expression profiling of skeletal muscle in exercise-trained and sedentary rats with inborn high and low VO2max. Physiological Genomics, 35(3), pp. 213-221. (doi:10.1152/physiolgenomics.90282.2008) Adamson, M., MacQuaide, N., Helgerud, J., Hoff, J., and Kemi, O.J. (2008) Unilateral arm strength training improves contralateral peak force and rate of force development. European Journal of Applied Physiology, 103(5), pp. 553-559. (doi:10.1007/s00421-008-0750-6) (PMID:18443814) Kemi, O.J., Ellingsen, O., Smith, G.L., and Wisloff, U. (2008) Exercise-induced changes in calcium handling in left ventricular cardiomyocytes. Frontiers in Bioscience, 13, pp. 356-368. (doi:10.2741/2685)