Desbonnet, Lieve - University of Glasgow

研究领域

Neurodevelopmental disorders and the impact environmental factors (stress, infection, perturbations of the gut microbiota) experienced during early life have on brain development and behaviour, particularly social and cognitive behaviours. The interplay between these environmental factors and identified risk genes, and the mechanisms by which gene-environment interactions alter the trajectory of brain development to increase the risk for schizophrenia and autism

近期论文

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Desbonnet, L., Cox, R., Tighe, O., Lai, D., Harvey, R. P., Waddington, J. L., and O'Tuathaigh, C. M.P. (2017) Altered cytokine profile, pain sensitivity, and stress responsivity in mice with co-disruption of the developmental genes Neuregulin-1 × DISC1. Behavioural Brain Research, 320, pp. 113-118. (doi:10.1016/j.bbr.2016.11.049) (PMID:27916686) O'Tuathaigh, C. M.P. et al. (2017) Epistatic and independent effects on schizophrenia-related phenotypes following co-disruption of the risk factors Neuregulin-1 × DISC1. Schizophrenia Bulletin, 43(1), pp. 214-225. (doi:10.1093/schbul/sbw120) (PMID:27613806) Moran, P., Stokes, J., Marr, J., Bock, G., Desbonnet, L., Waddington, J., and O’Tuathaigh, C. (2016) Gene × environment interactions in schizophrenia: evidence from genetic mouse models. Neural Plasticity, 2016, 2173748. (doi:10.1155/2016/2173748) (PMID:27725886) (PMCID:PMC5048038) Golubeva, A. V. et al. (2015) Prenatal stress-induced alterations in major physiological systems correlate with gut microbiota composition in adulthood. Psychoneuroendocrinology, 60, pp. 58-74. (doi:10.1016/j.psyneuen.2015.06.002) (PMID:26135201) Desbonnet, L., Clarke, G., Traplin, A., O’Sullivan, O., Crispie, F., Moloney, R.D., Cotter, P.D., Dinan, T.G., and Cryan, J.F. (2015) Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour. Brain, Behavior, and Immunity, 48, pp. 165-173. (doi:10.1016/j.bbi.2015.04.004) (PMID:25866195) O’Leary, C., Desbonnet, L., Clarke, N., Petit, E., Tighe, O., Lai, D., Harvey, R., Waddington, J.L., and O’Tuathaigh, C. (2014) Phenotypic effects of maternal immune activation and early postnatal milieu in mice mutant for the schizophrenia risk gene neuregulin-1. Neuroscience, 277, pp. 294-305. (doi:10.1016/j.neuroscience.2014.06.028) O'Tuathaigh, C. M.P., Desbonnet, L., and Waddington, J. L. (2014) Genetically modified mice related to schizophrenia and other psychoses: seeking phenotypic insights into the pathobiology and treatment of negative symptoms. European Neuropsychopharmacology, 24(5), pp. 800-821. (doi:10.1016/j.euroneuro.2013.08.009) Moloney, R. D., Desbonnet, L., Clarke, G., Dinan, T. G., and Cryan, J. F. (2014) The microbiome: stress, health and disease. Mammalian Genome, 25(1-2), pp. 49-74. (doi:10.1007/s00335-013-9488-5) Desbonnet, L., Clarke, G., Shanahan, F., Dinan, T.G., and Cryan, J.F. (2014) Microbiota is essential for social development in the mouse. Molecular Psychiatry, 19(2), pp. 146-148. (doi:10.1038/mp.2013.65) Desbonnet, L., O’Tuathaigh, C. M.P., and Waddington, J. L. (2012) Modeling schizophrenia: uncovering novel therapeutic targets. Expert Review of Clinical Pharmacology, 5(6), pp. 667-676. (doi:10.1586/ecp.12.57) Walsh, J., Desbonnet, L., Clarke, N., Waddington, J.L., and O'Tuathaigh, C.M.P. (2012) Disruption of exploratory and habituation behavior in mice with mutation of DISC1: an ethologically based analysis. Journal of Neuroscience Research, 90(7), pp. 1445-1453. (doi:10.1002/jnr.23024) Desbonnet, L. et al. (2012) Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: a putative model of gene×environment interaction. Brain, Behavior, and Immunity, 26(4), pp. 660-671. (doi:10.1016/j.bbi.2012.02.010) Desbonnet, L., Tighe, O., Karayiorgou, M., Gogos, J. A., Waddington, J. L., and O’Tuathaigh, C. M.P. (2012) Physiological and behavioural responsivity to stress and anxiogenic stimuli in COMT-deficient mice. Behavioural Brain Research, 228(2), pp. 351-358. (doi:10.1016/j.bbr.2011.12.014) O'Tuathaigh, C. M.P. et al. (2012) Genetic vs. pharmacological inactivation of COMT influences cannabinoid-induced expression of schizophrenia-related phenotypes. International Journal of Neuropsychopharmacology, 15(9), pp. 1331-1342. (doi:10.1017/S1461145711001581) O’Tuathaigh, C. M.P., Desbonnet, L., Lee, P., and Waddington, J. L. (2012) Catechol-O-methyl transferase as a drug target for schizophrenia. CNS and Neurological Disorders: Drug Targets, 11(3), pp. 282-291. (doi:10.2174/187152712800672418) O’Tuathaigh, C. M.P., Desbonnet, L., and Waddington, J. L. (2012) Mutant mouse models in evaluating novel approaches to antipsychotic treatment. Handbook of Experimental Pharmacology, 213, pp. 113-145. (doi:10.1007/978-3-642-25758-2_5) Desbonnet, L., Garrett, L., Clarke, G., Kiely, B., Cryan, J.F., and Dinan, T.G. (2010) Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression. Neuroscience, 170(4), pp. 1179-1188. (doi:10.1016/j.neuroscience.2010.08.005) O'Tuathaigh, C. M.P. et al. (2010) Chronic Adolescent Exposure to Δ-9-tetrahydrocannabinol in COMT mutant mice: impact on psychosis-related and other phenotypes. Neuropsychopharmacology, 35(11), pp. 2262-2273. (doi:10.1038/npp.2010.100) O’Tuathaigh, C. M.P., Desbonnet, L., and Waddington, J. L. (2009) Neuregulin-1 signaling in schizophrenia: 'Jack of all trades' or master of some? Expert Review of Neurotherapeutics, 9(1), pp. 1-3. (doi:10.1586/14737175.9.1.1) Desbonnet, L., Waddington, J. L., and O'Tuathaigh, C. M.P. (2009) Mutant models for genes associated with schizophrenia. Biochemical Society Transactions, 37(1), pp. 308-312. (doi:10.1042/BST0370308) Desbonnet, L., Garrett, L., Clarke, G., Bienenstock, J., and Dinan, T. G. (2008) The probiotic Bifidobacteria infantis: an assessment of potential antidepressant properties in the rat. Journal of Psychiatric Research, 43(2), pp. 164-174. (doi:10.1016/j.jpsychires.2008.03.009) Desbonnet, L., Garrett, L., Daly, E., McDermott, K. W., and Dinan, T. G. (2008) Sexually dimorphic effects of maternal separation stress on corticotrophin-releasing factor and vasopressin systems in the adult rat brain. International Journal of Developmental Neuroscience, 26(3-4), pp. 259-268. (doi:10.1016/j.ijdevneu.2008.02.004) Van den Hove, D. L.A., Blanco, C. E., Scheepens, A., Desbonnet, L., Myint, A.-M., Leonard, B. E., Prickaerts, J., and Steinbusch, H. W.M. (2008) Prenatal maternal paroxetine treatment and neonatal mortality in the rat: a preliminary study. Neonatology, 93(1), pp. 52-55. (doi:10.1159/000106433) O'Mahony, S. M., Myint, A.-M., van den Hove, D., Desbonnet, L., Steinbusch, H., and Leonard, B. E. (2006) Gestational stress leads to depressive-like behavioural and immunological changes in the rat. Neuroimmunomodulation, 13(2), pp. 82-88. (doi:10.1159/000096090) Van den Hove, D.L.A., Blanco, C.E., Aendekerk, B., Desbonnet, L., Bruschettini, M., Steinbusch, H.P., Prickaerts, J., and Steinbusch, H.W.M. (2005) Prenatal restraint stress and long-term affective consequences. Developmental Neuroscience, 27(5), pp. 313-320. (doi:10.1159/000086711)