研究领域

Bioorganic Chemistry/Natural Product Chemistry

Our research interest is focused on the chemistry and biochemistry of secondary metabolites, in particular lipid substances, including terpenoids and steroids. The structures, biosynthetic pathway and physiological roles of these substances are subjects of our studies. Knowledge of synthetic organic chemistry, biochemistry, molecular biology and ecology will be useful in our study. For further detail, visit our homepage and enjoy outlines of each project. Research Topics : Study on a membrane receptor of the molting hormone, 20-hydroxyecdysone. Study on the chemistry and physiological roles of secondary metabolites secreted from glandular trichomes of plants. Fundamental study on the utilization of the enzymes that catalyze the conversion of phytosterols to cholesterol in insects. Study on the biosynthesis of 20-hydroxyecdysone in insects as well as plants. Study on the biosynthesis of ecdysteroid side chain in plants. Study on a novel acid-catalyzed Meerwein-Wagner rearrangement of ecdysteroids. Isolation and structure elucidation of new natural products of plant origin. Study on the biosynthetic mechanism of steroidal backbone in plants. Study on the biosynthesis of steroidal alkaroids in Solanaseae plants. Message from the LaboratoryWe would like to broaden our understanding of the secondary metabolites from various standpoints, e.g., structure, biosynthesis, physiological role, and possible utilization. Many students from other universities affiliate with our laboratory. We welcome students with high motivation in higher education and research. Start line is the same almost for all newcomers who may have little knowledge in this field. Then, you will be experts in our fields after several months. Let's join us to see an interesting world developed by natural products!

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Cyclic fatty acyl glycosides in the glandular trichome exudate of Cerastium glomeratum, T. Asai, Y. Nakamura, Y. Hirayama, K. Ohyama, Y. Fujimoto, Chemistry & Biodiv., in press. Malonylated glycerolipids from the glandular trichome exudate of Ceratotheca triloba, A. Ohkawa, T. Sakai, K. Ohyama, Y. Fujimoto, Chemistry & Biodiv., in press. Epi-α-bisabolol 6-deoxy-β-D-gulopyranoside, from glandular trichome exudates of Brillantaisia lamiumr, T. Asai, Y. Hirayama, Y. Moriguchi, Y. Fujimoto, Phytochemistry Lett., 5, 376-378 (2012). Revison of the stereochemistry of elisabethatriene, a putative biosynthetic intermediate of pseudopterosin, M. Nasuda, M. Ohmori, K. Ohyama, Y. Fujimoto, Chem. Pharm. Bull., 60, 681-685 (2012). Antioxidant flavonol glycosides from Elaecarpus serratus and Filicium decipiens, L. Jayasinghe, M. Lakdusinghe, Y. Fujimoto, Nat. Prod. Res., 26, 717-721(2012). Phenolic constituents from the fruit juice of Flacourtia inermis, L. Jayasinghe, M. Lakdusinghe, Y. Fujimoto, Nat. Prod. Res., 26, 278-281 (2012). Isolation and identification of two sterols and a triterpene from dry fruiting bodies of Ganoderma lucidum caltivated in Colombia, H. P. Moreno, A. M. Martinez, Y. Fujimoto, Vitae, 18, 11-15 (2011). n-Octyl α-L-rhamnopyranosyl-(1-2)-β-D-glucopyranoside derivatives from the glandular trichome exudate of Ganoderma carolinianum, T. Asai, T. Sakai, Y. Fujimoto, Chem. Pharm. Bull., 59, 747-752 (2011). C-24 Stereochemistry of marine sterols: (22E)-24-ethyl-24-methylcholesta-5,22-dien-3β-ol and 24-ethyl-24-methylcholest-5-en-3β-ol , S. Echigo, L. Castellano, C. Duque, H. Uekusa, N. Hara, Y. Fujimoto, J. Braz. Chem. Soc., 22, 995-1002 (2011). Flavonols and anthocyanins from Sicana odorifea fruit peel, K. Jaramillo, C. David, T. Hofmann, Y. Fujimoto, C. Osorio, J. Nat. Prod., 100, 111-114 (2011). 2-Acetyl-1-(3-glycosyloxyoctadecanoyl)glycerol and dammarane triterpenes in the exudates from glandular trichome-like secretory organs on the stuples and leaves of Cerasus yedoenesis, T. Asai, Y. Fujimoto, Phytochemistery Lett., 4, 38-42 (2011). Non-molting glossylshroud encodes a short-chain dehydrogenase/reductase that functions in the "Black Box" of the ecdysteroid biosynthesis pathway, R. Niwa, T. Namiki, K. Ito, Y. Shimada-Niwa, M. Kikuchi, S. Kawaoka, T. Kayukawa, Y. Banno, Y. Fujimoto, S. Shigenobu, S. Kobayashi, T. Shimada, S. Katsuma, T. Shinoda, Development, 137, 1991-1999 (2010). Artabotryols A-E, new lanostanetriterpenes from the seeds of Artabotrys odoratissimus, C. Gupta, S. Prasad, M. Sahai, T. Asai, N. Hara, Y. Fujimoto, Helv. Chim. Acta, 93, 000-000 (2010). Cyclic fatty acyl glucosides from the glandular trichome exudate of Silene gallica, T. Asai, Y. Fujimoto, Phytochemistry, 71, 1410-1417 (2010). Fatty acid derivatives and dammarane triterpenes from the glandular trichome exudates of Ibicella lutea and Proboscidea louisiana, T. Asai, N. Hara, Y. Fujimoto, Phytochemistry, 71, 877-894 (2010).