Prunet, Joelle - University of Glasgow

研究领域

The main research interest of the Prunet group is the synthesis of biologically active natural products, such as taxol, a powerful antitumor agent, or dolabelide C and hexacyclinic acid, molecules with cytotoxic activity. In our approaches towards the target molecules, we uncover problems that cannot be easily solved by known reactions, and to overcome these difficulties we try to develop new methodologies that can also be applied to other syntheses

近期论文

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Ma, C., Letort, A., Aouzal, R., Wilkes, A., Maiti, G., Farrugia, L. J., Ricard, L., and Prunet, J. (2016) Cascade metathesis reactions for the synthesis of taxane and isotaxane derivatives. Chemistry: A European Journal, 22(20), pp. 6891-6899. (doi:10.1002/chem.201600592) (PMID:27062670) Letort, A., Aouzal, R., Ma, C., Long, D.-L., and Prunet, J. (2014) Highly efficient synthesis of the tricyclic core of Taxol by cascade metathesis. Organic Letters, 16(12), pp. 3300-3303. (doi:10.1021/ol501304j) Chevalley, A., Prunet, J., Mauduit, M., and Ferezou, J.-P. (2013) Model studies for a ring-closing metathesis approach to the Bafilomycin macrolactone core from a 2,2-dimethoxy tetraenic ester precursor. European Journal of Organic Chemistry, 2013(36), pp. 8265-8278. (doi:10.1002/ejoc.201300559) Redon, S., Wierzbicki,, M., and Prunet, J. (2013) A new oxa-michael reaction and a gold-catalysed cyclisation en route to C-glycosides. Tetrahedron Letters, 54(16), pp. 2089-2092. (doi:10.1016/j.tetlet.2013.02.022) Prunet, J. (2011) Progress in metathesis through natural product synthesis. European Journal of Organic Chemistry, 2011(20-21), pp. 3634-3647. (doi:10.1002/ejoc.201100442) Braun, M.G., Vincent, A., Boumediene, M., and Prunet, J. (2011) Highly demanding cross metathesis in the synthesis of the C16-C30 fragment of dolabelide C. Journal of Organic Chemistry, 76(12), pp. 4921-4929. (doi:10.1021/jo200466t) Gamba-Sanchez, D., and Prunet, J. (2010) Synthesis of modified methyl furanosides by intramolecular oxa-Michael reaction followed by Pummerer rearrangement. Journal of Organic Chemistry, 75(9), pp. 3129-3132. (doi:10.1021/jo100241e)