Bradley, Mark - University of Edinburgh

个人简介

Mark Bradley is Professor of Chemical Biology in the School of Chemistry at The University of Edinburgh and holds an Honouree Professorship at the Queens Medical Research Institute with laboratories based in both locations After gaining a First class Honours B. Sc. Degree in Chemistry with Distinction in Biochemistry, he carried out a D. Phil under the supervision of Professor Sir J. E. Baldwin FRS – both at the University of Oxford. On gaining both a Lindemann Trust and SERC/NATO Postdoctoral Fellowships, he continued with postdoctoral work under Professor C. T. Walsh at Harvard Medical School in Boston, USA (1989-1991) before moving to the University of Southampton as a Royal Society University Research Fellow. In 1997 at the age of 34 he was awarded a Professorship in Combinatorial Chemistry where he founded the Combinatorial Centre of Excellence. He continued to direct this Centre until moving to Edinburgh in 2005 where he took up his current position as Professor of Chemical Biology. Since this time his work has become much more focused on the application of chemistry to solving medical problems (chemical medicine) which has resulted, for example in the extensive collaboration between the groups of Bradley, Dhaliwal and Haslett in the area of “smart-probes” for clinical and pre-clinical imaging. More than 60 PhD students have emerged from the Bradley group and overall the group has published more than 20 patents and 300 articles in the form of papers, reviews and book chapters.

研究领域

Microarrays (cells, small molecules, and polymers); cellular delivery (DNA, proteins, peptides); high-throughput chemistry and optical imaging. Polymer Microarrays We have developed a platform where-by we can fabricate polymer microarrays, consisting of thousands of polymers on a single microscope slide. These slides can be interrogated with a variety of cells, with subsequent high-content screening, allowing the identification of a specific polymer that binds or otherwise modulates cellular function. Importantly, once the specific polymer has been identified we have shown that we can seamlessly scale-up to allow much larger scale application. We have used polymer microarrays for the identification of polymers to control stem cell differentiation and global transfection, find polymers for bacterial scavenging and capture and polymer matrices that promote and stabilize hepatocyte function. Cellular Delivery The group has also developed chemical based delivery systems for both small molecule chemical based sensors and macromolecule delivery (PNA, DNA and proteins). Some of these cross the skin barrier and have uses in dermatological applications.

近期论文

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Solid-Phase Synthesis of Fluorescent Probes for Plasma Membrane Labelling S. Zhang, A, Lilienkampf and M. Bradley Molecules, 2021 A fluorogenic peptide-based smartprobe for the detection of neutrophil extracellular traps and inflammation M. R. Rios, G. Garoffolo, G. Rinaldi, A. Megia-Fernandez, S. Ferrari, C. T. Robb, A. G. Rossi, M. Pesce and M. Bradley Chem. Commun., 2021 Bioorthogonal Swarming: In Situ Generation of Dendrimers Y. Zhang, M. Üçüncü, A. Gambardella, A. Baibek, J. Geng, S. Zhang, J. Clavadetscher, I. Litzen, M. Bradley, and A. Lilienkampf J. Am. Chem. Soc., 2021 Optical Detection of Distal Lung Enzyme Activity in Human Inflammatory Lung Disease A. Megia-Fernandez, A. Marshall, A. R. Akram, B. Mills, S. V. Chankeshwara, E. Scholefield, A. Miele, B. C. McGorum, C. Michaels, N. Knighton, T. Vercauteren, F. Lacombe, V. Dentan, A. M. Bruce, J. Mair, R. Hitchcock, N. Hirani, C. Haslett, M. Bradley and K. Dhaliwal Polymyxin-based photosensitizer for the potent and selective killing of Gram-negative bacteria M. Ucuncu, B. Mills, S. Duncan, Matteo Staderini, Kevin Dhaliwal and M. Bradley Chem. Commun., 2020 Rapid fabrication and screening of tailored functional 3D biomaterials A. Conde-Gonzáleza, D. Duttaa, R. Wallace, A. Callanan and M. Bradley Materials Science Eng C., 2019 Wash‐free, peptide‐based fluorogenic probes for microbial imaging A. Baibek, Muhammed Üçüncü, E. A. Blackburn, M. Bradley and A. Lilienkampf Peptide Science, 2020 A matrix metalloproteinase activation probe for painting human tumours B. Mills, D. Norberg, K. Dhaliwal, A. R. Akram, M. Bradley and A. Megia-Fernandez Chem. Commun., 2020 Exploratory Use of Fluorescent SmartProbes for the Rapid Detection of Microbial Isolates Causing Corneal Ulcer R. Gunasekarana, P. Lalithaa, A. Megia-Fernandez, M. Bradley, R. L.Williams, K. Dhaliwald, N. Venkatesh Prajna and B. Mills Am. J. Ophthalmology, 2020 Multifunctional, histidine-tagged polymers: antibody conjugation and signal amplification Y. Zhang, A. Gambardella, M. Üçüncü, J. Geng, J. Clavadetscher, M. Bradley and A. Lilienkampf Chem. Commun., 2020 Time-Resolved Spectroscopy of Fluorescence Quenching in Optical Fibre-Based pH Sensors K. Ehrlich, T. R. Choudhary, M. Ucuncu, A. Megia-Fernandez, K. Harrington, H. A. C. Wood, F. Yu, D. Choudhury, K. Dhaliwal, M. Bradley and M. G. Tanner Sensors, 2020 Radical polymerization inside living cells J. Geng, W. Li, Y. Zhang, N. Thottappillil, J. Clavadetscher, A. Lilienkampf and M. Bradley Nature Chemistry, 2019 Solid-phase synthesis of biocompatible N-heterocyclic carbene–Pd catalysts using a sub-monomer approach D. Cherukaraveedu, P. T. Cowling, G. P. Birch, M. Bradley and A. Lilienkampf Org. Biomol. Chem., 2019 Polymer Microarrays for the Discovery and Optimization of Robust Optical-Fiber-Based pH Sensors J. Gong, S. Venkateswaran, M. G. Tanner, J. M. Stone and M. Bradley ACS Comb. Sci., 2019 High fidelity fibre-based physiological sensing deep in tissue T. R. Choudhary, M. G. Tanner, A. Megia-Fernandez, K. Harrington, H. A. Wood, A. Marshall, P. Zhu, S. V. Chankeshwara, D. Choudhury, G. Monro, M. Ucuncu, F. Yu, R. R. Duncan, R. R. Thomson, K. Dhaliwal and M. Bradley Scientific Reports, 2019 In situ identification of Gram-negative bacteria in human lungs using a topical fluorescent peptide targeting lipid A A. R. Akram, S. V. Chankeshwara, E. Scholefield, T. Aslam, N. McDonald, A. Megia-Fernandez, A. Marshall, B. Mills, N. Avlonitis, T. H. Craven, A. M. Smyth, D. S. Collie, C. Gray, N. Hirani, A. T. Hill, J. R. Govan, T. Walsh, C. Haslett, M. Bradley and K. Dhaliwal Science Translational Medicine, 2019 Photo-controlled one-pot strategy for the synthesis of asymmetric three-arm star polymers Yichuan Zhang, Mark Bradley and Jin Geng Polym. Chem., 2019 A Dual Killing Strategy: Photocatalytic Generation of Singlet Oxygen with Concomitant PtIV Prodrug Activation D. J. Norman, A. Gambardella, A. R. Mount, A. F. Murray and M. Bradley Angew. Chem. Int. Ed., 2019 Enhanced avidity from a multivalent fluorescent antimicrobial peptide enables pathogen detection in a human lung model A. R. Akram, N. Avlonitis, E. Scholefield, M. Vendrell, N. McDonald, T. Aslam, T. H. Craven, C. Gray, D. S. Collie, A. J. Fisher, P. A. Corris, T. Walsh, C. Haslett, M.Bradley and K. Dhaliwal Scientific Reports, 2019 A tripod anchor offers improved robustness of peptide-based electrochemical biosensors M. Staderini, E. González-Fernández, A. F. Murray, A. R. Mount and M. Bradley Sensors and Actuators B: Chemical, 2018 Bimodal fluorogenic sensing of matrix proteolytic signatures in lung cancer A. Megia-Fernandez, B. Mills, C. Michels, S. V. Chankeshwara, N. Krstajić, C. Haslett, K. Dhaliwal and M. Bradley Org. Biomol. Chem., 2018 Super-silent FRET Sensor Enables Live Cell Imaging and Flow Cytometric Stratification of Intracellular Serine Protease Activity in Neutrophils T. H. Craven, N. Avlonitis, N.McDonald, T. Walton, E. Scholefield, A. R. Akram, T. S. Walsh, C. Haslett, M. Bradley & K. Dhaliwal Scientific Reports, 2018