ZAMOYSKA, Rose - University of Edinburgh - School of Biological Sciences

个人简介

1981 PhD in Immunology, Department of Pathology, University of Cambridge 1981-1984 Postdoctoral Research Assistant, Department of Pathology, University of Cambridge 1984-1987 Postdoctoral Research Fellow, Dept. of Medicine, Stanford University, U.S.A. 1987-1991 Research Scientist, ICRF, Tumour Immunology Unit, University College London 1991-2007 Senior Research Scientist, MRC National Institute for Medical Research, Mill Hill, London 2007-present Professor of Immune Cell Biology, University of Edinburgh

研究领域

We are interested in understanding how T lymphocytes communicate with their environment both during differentiation in the thymus and subsequently in the periphery to regulate survival, expansion and further differentiation into effector or memory cells, while maintaining tolerance. In particular we are focussed on the role of the Src-kinase family and their modifiers such as the phosphatase, PTPN22, in facilitating responsiveness to antigens while retaining tolerance to self-proteins.

近期论文

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Zamoyska, R., A. Basson, A. Filby, G. Legname, M. Lovatt and B. Seddon (2003) The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activation. Immunol. Rev. 191: 107-118. Lovatt, M., A. Filby, V. Parravicini, G. Werlen, E. Palmer and R. Zamoyska (2006) Lck Regulates the Threshold of Activation in Primary T Cells, While both Lck and Fyn Contribute to the Magnitude of the Extracellular Signal-Related Kinase Response. Mol. Cell. Biol. 26: 8655-8665. Filby, A., B. Seddon, J. Kleczkowska, R. Salmond, P. Tomlinson, M. Smida, J. A. Lindquist, B. Schraven and R. Zamoyska (2007) Fyn regulates the duration of TCR engagement needed for commitment to effector function. J. Immunol. 179: 4635-4644. Salmond, R.J., J. Emery, K. Okkenhaug, and R. Zamoyska. 2009. MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells. J Immunol 183:7388-7397 Salmond, R.J., A. Filby, N. Pirinen, A.I. Magee, and R. Zamoyska. 2010. Mislocalization of Lck impairs thymocyte differentiation and can promote development of thymomas. Blood 117:108-117 Tsun, A., I. Qureshi, J.C. Stinchcombe, M.R. Jenkins, M. de la Roche, J. Kleczkowska, R. Zamoyska, and G.M. Griffiths. 2011. Centrosome docking at the immunological synapse is controlled by Lck signaling. J Cell Biol 192:663-674 Caserta, S., J.G. Borger, and R. Zamoyska. 2012. Central and effector memory CD4 and CD8 T-cell responses to tumor-associated antigens. Crit Rev Immunol 32:97-126 Brownlie, R, Miosge, L, Vassilakos, D, Svensson, L., Cope, A and Zamoyska, R. 2012 Loss of PTPN22 improves murine regulatory T cell function by influencing T cell receptor and integrin signaling. Science Signaling 5:ra87 Brownlie, R.J., and R. Zamoyska. 2013. T cell receptor signalling networks: branched, diversified and bounded. Nat Rev Immunol 13:257-269 Borger, J.G., A. Filby, and R. Zamoyska. 2013. Differential polarisation of Csk between na?ve and antigen-experienced CD8+ T cells. J. Immunol. 190:3089-99