THOMPSON, Joanne - University of Edinburgh - School of Biological Sciences

个人简介

1989 PhD. Institute of Neurology. University of London 1989-1992 Postdoc: ICRF Developmental Biology Unit, Oxford 1992-1996 Department of Biology, Imperial College, London 1996-1998 EMBL, Heidelberg, Germany 1999-2001 Leiden University Medical Centre, The Netherlands 2001-2010 MRC Research Fellow: University of Edinburgh 2010-Present Lecturer in Molecular Parasitology, University of Edinburgh

研究领域

The malaria parasite has a surprisingly complex life cycle in its vertebrate host and mosquito vector and is capable of interacting with and invading a range of host tissues. In establishing a long-lasting infection in mammalian hosts, the parasite must also detect and respond to changes in its cellular environment and modulate the development of an effective host immune response. My primary research interest lies in exploring these host-parasite interactions at the molecular and cellular level; in particular carrying out functional analyses of parasite integral-membrane proteins that share features with G-Protein Coupled Receptors and Tumour Necrosis Factor Receptors and so are implicated in signal transduction and immunomodulation. These studies have also recently led to the development of gene transformation technologies in Plasmodium chabaudi; the experimental malaria parasite model that most closely resembles human malaria infection. This has opened the way to directly visualize host immune cell-parasite interactions and to investigate immune responses to parasites in which candidate immunomodulatory genes have been deleted.

近期论文

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Medeiros MM, da Silva HB, Reis AS, Barboza R, Thompson J, Lima MR, Marinho CR, Tadokoro CE. (2013) Liver Accumulation of Plasmodium chabaudi-Infected Red Blood Cells and Modulation of Regulatory T Cell and Dendritic Cell Responses. PLoS One. Nov 27;8(11):e81409. Brugat T, Cunningham D, Sodenkamp J, Coomes S, Wilson M, Spence PJ, Jarra W, Thompson J, Scudamore C, Langhorne J. (2013) Sequestration and histopathology in Plasmodium chabaudi malaria are influenced by the immune response in an organ-specific manner. Cell Microbiol. 2013 Sep 5 Douradinha B, Augustijn KD, Moore SG, Ramesar J, Mota MM, Waters AP, Janse CJ and Thompson J (2011) Plasmodium berghei Cysteine Repeat Modular Proteins 3 and 4 are essential for parasite transmission from the mosquito to the host. Malaria J. 10:71 Spence PJ, Cunningham D, Jarra W, Lawton J, Langhorne JL and Thompson J. (2011) Transformation of the rodent malaria parasite, Plasmodium chabaudi. Nature Protocols. 6: 553-561 Brown DE, Belyaev NN, Garcia Diaz A-I, Foster KE, Rae A, Jarra W, Koernig S, Thompson J, Langhorne J and Potocnik AJ. (2010) Induction of a novel population of IL 7Ra + myelolymphoid progenitors during acute malaria infection Nature Immunology. 11: 477-85 Sponaas A-M, Mastelic B, Voisine C, Potocnik A, Thompson J, Koernig S, Jarra W, Renia L, Mauduit M, and Langhorne J (2009) Migrating monocytes recruited to the spleen play an important role in early control of blood stage malaria. Blood. 114(27): 5522-31. Reece SE & Thompson J (2008) Transfection of the rodent malaria, Plasmodium chabaudi: a constitutively fluorescent reference line. Malaria Journal. 7; 183-189 Thompson J, Millington O, Garside P and Brewer J (2008) What Can Transgenic Parasites Tell Us About The Development Of Plasmodium-Specific Immune Responses? Parasite Immunology. 30: 223-33 Dixon MWA, Thompson J, Gardiner DL and Trenholme KR. (2008) Sex In Plasmodium A Sign of Commitment. Trends in Parasitology. 24: 168-75 Thompson J, Fernandez-Reyes D, Sharling L, Kyes S, Newbold CI, Eling W, Kafatos FC, Janse CJ and AP Waters. (2007) Plasmodium Cysteine Repeat Modular Proteins 1-4: complex proteins with roles throughout the parasite lifecycle. Cellular Microbiology. 9:1466-1480