TAYLOR, Matthew - University of Edinburgh - School of Biological Sciences

个人简介

1995 Research Assistant, Universtity of Glasgow 1996 Research Assistant, Universidade Federal de Minas Gerais, Brazil 1996-2000 PhD, University of Manchester 2000-2001 Post-Doctoral Fellow, University of British Columbia 2001-2006 Post-Doctoral Researcher, University of Edinburgh 2006-Present MRC Career Development Fellow, University of Edinburgh

研究领域

The orchestration of a successful immune response requires a tight balance between mobilising a sufficient and correct effector response, whilst simultaneously regulating that response to prevent it becoming pathogenic. Helminth parasites excel at subverting this balance, using the host's own immune regulatory mechanisms to prevent effective immunity, resulting in immune suppression and chronic infection in the majority of individuals.

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Taylor M.D., Le Goff. L., Harris A., Malone E., Allen, J.E., and Maizels, R.M. (2005) Removal of regulatory T cell activity reverses hyporesponsiveness and leads to filarial parasite clearance in vivo. J. Immunol., 174: 4924-4933. Taylor, M.D., Harris, A., Babayan, S.A., Bain, O., Culshaw, A., Allen, J.E., and Maizels, R.M. (2007) CTLA-4 and CD4 +CD25 + regulatory T cells inhibit protective immunity to filarial parasites in vivo. J. Immunol. 179: 4626-4634. Wilson M.S., Taylor M.D., Balic A., Finney C.A.M., Lamb J.R., and Maizels R.M. (2005) Suppression of Allergic Airway Inflammation by Helminth-Induced Regulatory T Cells. J. Exp. Med., 202: 1199-1212. Taylor M.D., Harris A., Nair M.G., Maizels R.M., and Allen J.E. (2006) F4/80 + alternatively activated macrophages control CD4 + T cell hypo-responsiveness at sites peripheral to filarial infection. J. Immunol. 176: 6918-6927. Finney, C.A.M., Taylor, M.D., Wilson, M.S., and Maizels, R.M. (2007) Expansion and activation of CD4 +CD25 + regulatory T cells in Heligmosomoides polygyrus infection. Eur. J. Immunol. 37: 1874-1876.