STANCHEVA, Irina - University of Edinburgh - School of Biological Sciences

个人简介

Irina graduated from University of Sofia, Bulgaria, and did her PhD at the Institute of Cell Biology, ETH Zurich, Switzerland, with Dr Jose M. Sogo. She joined Richard Meehan's laboratory at the University of Edinburgh in 1997 as a postdoctoral scientist and in 2002 became a Carcer Research UK Senior Research Fellow and established her lab at the School of Biomedical Sciences. In 2004, she joined the Wellcome Trust Centre for Cell Biology and became University Reader in 2012. Irina has been studying the role of chromatin and DNA methylation in epigenetic regulation of gene expression since she started her PhD. When she is not in the lab, Irina plays tennis or hikes in the mountains.

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Termanis, A., Torrea, N., Culley, J., Kerr, A., Ramsahoye, B. and Stancheva, I. (2016) The SNF2 family ATPase LSH promotes cell-autonomous de novo DNA methylation in somatic cells, Nucleic Acids Res - published online 13 May Zhang, T., Termanis, A., Ozkan, B., Bao, X.X., Culley, J., de Lima Alves, F., Rappsilber, J., Ramsahoye, B. and Stancheva, I. (2016) G9a/GLP complex maintains imprinted DNA methylation in embryonic stem cells, Cell Reports 15, 77-85 Stancheva, I. and Schirmer, E.C. (2014) Nuclear envelope: connecting structural genome organization to regulation of gene expression, Adv Exp Med Biol 773, 209-244 - a chapter in e-book "Cancer Biology and the Nuclear Envelope", Springer Gordon, K., Clouaire, T., Bao, X.X., Kemp, S.E., Xenophontos, M., de las Heras, J.I. and Stancheva, I. (2014) Immortality, but not oncogenic transformation, of primary human cells leads to epigenetic reprogramming of DNA methylation and gene expression, Nucleic Acids Res 42: 3529-3541 Monnier,P., Pontis, J., Martinet, C., Stancheva, I., Ait-Si-Ali, S. and Dandolo, L. (2013) H19 lncRNA controls gene transcription of the Imprinted Gene Network by recruiting MBD1, Proc Natl Acad Sci USA 110: 20693-20698 Burrage, J., Termanis, A., Geissner, A., Myant, K., Gordon, K. and Stancheva, I. (2012) The SNF2 family ATPase LSH promotes phosphorylation of H2AX and efficient repair of DNA double-strand breaks in mammalian cells, J Cell Science 125: 5524-5534 Gendrel, A.V., Apedaile, A., Coker, H., Termanis, A., Zvetkova, I., Godwin, J., Tang, A., Huntley, D., Montana, G., Taylor, S., Giannoulatou, E., Heard, E., Stancheva, I. and Brockdorff, N. (2012) Smchd1-dependent and -independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome, Developmental Cell 23: 265-279 Myant, K., Termanis, A., Sundaram, Y.M.A., Boe. T., Merusi, C., Li, C., de las Heras, J.I. and Stancheva, I. (2011) LSH and G9a/GLP complex are required for developmentally programmed DNA methylation, Genome Research 21: 83–94 Stancheva, I. (2011) Revisiting heterochromatin in embryonic stem cells, PLoS Genetics 7(6), e1002093 Defossez, P.A. and Stancheva, I. (2011) Biological Functions of Methyl-CpG-Binding Proteins. Prog Mol Biol Transl Sci 101: 377-398 Clouaire, I, de las Heras J.I., Merusi, C. and Stancheva, I. (2010) Recruitment of MBD1 to target genes requires sequence-specific interaction of the MBD domain with methylated DNA, Nucleic Acids Res 14: 4620-4634 Athanasiadou R., de Sousa D., Myant K., Merusi C., Stancheva I. and Bird, A. (2010) Targeting of de novo DNA methylation throughout the Oct-4 gene regulatory region in differentiating embryonic stem cells., PLOS One 5(4): e9937 Clouaire, T. and Stancheva, I. (2008) Methyl-CpG binding proteins: specialized transcriptional repressors or structural components of chromatin? Cell. Mol. Life Sci. 65: 1509-1522 Myant, K. and Stancheva, I. (2008) LSH cooperates with DNA methyltransferases to repress transcription., Mol Cell Biol, 28: 215-226 Lyst, M.J. and Stancheva, I. (2007) A role for SUMO modification in transcriptional repression and activation., Biochem Soc Trans. 35:1389-92. Lyst, M.J., Nan, X. and Stancheva, I. (2006) Regulation of MBD1-mediated transcriptional repression by SUMO and PIAS proteins., EMBO J. 25: 5317- 2328 Klose, R.J., Sarraf, S.A., Schmiedeberg, L., McDermott, S.M., Stancheva, I. and Bird, A.P. (2005) DNA binding selectivity of MeCP2 due to a requirement for A/T sequences adjacent to methyl-CpG, Molecular Cell 19: 667-678 Stancheva, I. (2005) Caught in conspiracy: cooperation between DNA methylation and histone H3K9 methylation in the establishment and maintenance of heterochromatin, Biochemistry and Cell Biology 83: 385-95. Ruzov,A., Dunican,D.S., Prokhortchouk,A., Pennings,S., Stancheva,I., Prokhortchouk,E. and Meehan, R.R. (2004) Kaiso is a genome-wide repressor of transcription that is essential for amphibian development., Development 131: 6185-6194 Sarraf, S.A. and Stancheva, I. (2004) Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly, Molecular Cell 15: 595-605. Zlatanova, J, Stancheva, I. and Ciaiafa, P. (2004) “DNA Methylation and chromatin structure” book chapter in “Chromatin structure and dynamics: State-of-the-Art”, Elsevier Press Stancheva, I., Collins, A.L., Van der Veyver, I.B., Zoghbi, H and Meehan, R.R. (2003) A mutant form of MeCP2 protein associated with human Rett syndrome cannot be displaced from methylated DNA by Notch in Xenopus embryos., Molecular Cell 12: 425-435 Stancheva, I, El Maari, O., Walter, J., Nivelau, A. and Meehan, R.R. (2002) DNA methylation at promoter regions regulates the timing of gene activation in Xenopus laevis embryos., Developmental Biology 343: 155-165. Meehan, R.R., Pennings, S. and Stancheva, I. (2001) Lashings of DNA methylation, forkfuls of chromatin remodelling., Genes and Development 15: 3231-3236. Meehan, R.R. and Stancheva, I. (2001) Methylation in the control of gene expression in vertebrate development., Essays in Biochemistry 37: 59-70.