ROSSER, Susan - University of Edinburgh - School of Biological Sciences

个人简介

Susan is Professor of Synthetic Biology at the University of Edinburgh. She is Director of the Edinburgh Mammalian Synthetic Biology Research Centre, Co-director of the Edinburgh Genome Foundry for synthetic DNA synthesis and assembly. She also holds a prestigious EPSRC Leadership Fellowship in Synthetic Biology. Her research focuses on developing tools for synthetic biology approaches for pathway and genome engineering in bacteria, yeast and mammalian cell systems. The applications of her work include rapid strain engineering for production of high value secondary metabolites, cell lines for protein production, engineering bacteria to generate electricity and developing genetic tools for bio-computation: engineering cells to sense, process and memorise information. Previously Susan was a lecturer in Biotechnology at the Institute of Molecular, Cell and Systems Biology at the University of Glasgow before being promoted to Professor in 2012. Susan studied microbiology and genetics at the University of Dundee before doing a PhD on the mechanisms of multiple antibiotic resistance. She then moved to the Institute of Biotechnology at the University of Cambridge to work on the biotransformation of cocaine and high explosives.

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Jensen MV, Horsfall LE, Wardrope C, Togneri PD, Marles-Wright J, Rosser SJ. Characterisation of a New Family of Carboxyl Esterases with an OsmC Domain. PLoS One. 2016 Nov 16;11(11):e0166128. doi: 10.1371/journal.pone.0166128. PubMed PMID: 27851780. Boeke JD, Church G, Hessel A, Kelley NJ, Arkin A, Cai Y, Carlson R, Chakravarti A, Cornish VW, Holt L, Isaacs FJ, Kuiken T, Lajoie M, Lessor T, Lunshof J, Maurano MT, Mitchell LA, Rine J, Rosser S, Sanjana NE, Silver PA, Valle D, Wang H, Way JC, Yang L. GENOME ENGINEERING. The Genome Project-Write. Science. 2016 Jul 8;353(6295):126-7. doi: 10.1126/science.aaf6850. PubMed PMID: 27256881. Fletcher L, Rosser S, Elfick A. Exploring Synthetic and Systems Biology at the University of Edinburgh. Biochem Soc Trans. 2016 Jun 15;44(3):692-5. doi: 10.1042/BST20160006. Review. PubMed PMID: 27284029. Bowyer J, Zhao J, Subsoontorn P, Wong W, Rosser S, Bates D. Mechanistic Modeling of a Rewritable Recombinase Addressable Data Module. IEEE Trans Biomed Circuits Syst. 2016 May 24. [Epub ahead of print] PubMed PMID: 27244749. Yu N, Nützmann HW, MacDonald JT, Moore B, Field B, Berriri S, Trick M, Rosser SJ, Kumar SV, Freemont PS, Osbourn A. Delineation of metabolic gene clusters in plant genomes by chromatin signatures. Nucleic Acids Res. 2016 Mar 18;44(5):2255-65. doi: 10.1093/nar/gkw100. PubMed PMID: 26895889. Olorunniji FJ, Rosser SJ, Stark WM. Site-specific recombinases: molecular machines for the Genetic Revolution. Biochem J. 2016 Mar 15;473(6):673-84. doi: 10.1042/BJ20151112. Review. PubMed PMID: 26965385. Kanigowska P, Shen Y, Zheng Y, Rosser S, Cai Y. Smart DNA Fabrication Using Sound Waves: Applying Acoustic Dispensing Technologies to Synthetic Biology. J Lab Autom. 2016 Feb;21(1):49-56. doi: 10.1177/2211068215593754. Epub 2015 Jul 10. PubMed PMID: 26163567; PubMed Central PMCID: PMC4814025. Bowyer J, Jia Zhao, Rosser S, Colloms S, Bates D. Development and experimental validation of a mechanistic model of in vitro DNA recombination. Conf Proc IEEE Eng Med Biol Soc. 2015 Aug;2015:945-8. doi: 10.1109/EMBC.2015.7318519. PubMed PMID: 26736419. Fogg PC, Colloms S, Rosser S, Stark M, Smith MC. New applications for phage integrases. J Mol Biol. 2014 Jul 29;426(15):2703-16. doi: 10.1016/j.jmb.2014.05.014. Epub 2014 May 22. Review. PubMed PMID: 24857859; PubMed Central PMCID: PMC4111918. Kemen AC, Honkanen S, Melton RE, Findlay KC, Mugford ST, Hayashi K, Haralampidis K, Rosser SJ, Osbourn A. Investigation of triterpene synthesis and regulation in oats reveals a role for β-amyrin in determining root epidermal cell patterning. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8679-84. doi: 10.1073/pnas.1401553111. Epub 2014 May 27. PubMed PMID: 24912185; PubMed Central PMCID: PMC4060722. Colloms SD, Merrick CA, Olorunniji FJ, Stark WM, Smith MC, Osbourn A, Keasling JD, Rosser SJ. Rapid metabolic pathway assembly and modification using serine integrase site-specific recombination. Nucleic Acids Res. 2014 Feb;42(4):e23. doi: 10.1093/nar/gkt1101. Epub 2013 Nov 12. PubMed PMID: 24225316; PubMed Central PMCID: PMC3936721. Mugford ST, Louveau T, Melton R, Qi X, Bakht S, Hill L, Tsurushima T, Honkanen S, Rosser SJ, Lomonossoff GP, Osbourn A. Modularity of plant metabolic gene clusters: a trio of linked genes that are collectively required for acylation of triterpenes in oat. Plant Cell. 2013 Mar;25(3):1078-92. doi: 10.1105/tpc.113.110551. Epub 2013 Mar 26. Erratum in: Plant Cell. 2013 Sep;25(9):3632. PubMed PMID: 23532069; PubMed Central PMCID: PMC3634678. Olorunniji FJ, Buck DE, Colloms SD, McEwan AR, Smith MC, Stark WM, Rosser SJ. Gated rotation mechanism of site-specific recombination by ?C31 integrase. Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19661-6. doi: 10.1073/pnas.1210964109. Epub 2012 Nov 12. PubMed PMID: 23150546; PubMed Central PMCID: PMC3511744. Osbourn AE, O'Maille PE, Rosser SJ, Lindsey K. Synthetic biology. 4th New Phytologist Workshop, Bristol, UK, June 2012. New Phytol. 2012 Nov;196(3):671-7. doi: 10.1111/j.1469-8137.2012.04374.x. PubMed PMID: 23043589. Martino C, Kim SH, Horsfall L, Abbaspourrad A, Rosser SJ, Cooper J, Weitz DA. Protein expression, aggregation, and triggered release from polymersomes as artificial cell-like structures. Angew Chem Int Ed Engl. 2012 Jun 25;51(26):6416-20. doi: 10.1002/anie.201201443. Epub 2012 May 29. PubMed PMID: 22644870. Chanasakulniyom M, Martino C, Paterson D, Horsfall L, Rosser S, Cooper JM. Expression of membrane-associated proteins within single emulsion cell facsimiles. Analyst. 2012 Jul 7;137(13):2939-43. doi: 10.1039/c2an35047e. Epub 2012 Mar 22. PubMed PMID: 22441306. Martino C, Horsfall L, Chen Y, Chanasakulniyom M, Paterson D, Brunet A, Rosser S, Yuan YJ, Cooper JM. Cytoskeletal protein expression and its association within the hydrophobic membrane of artificial cell models. Chembiochem. 2012 Apr 16;13(6):792-5. doi: 10.1002/cbic.201200038. Epub 2012 Mar 12. PubMed PMID: 22411693. Seth-Smith HM, Edwards J, Rosser SJ, Rathbone DA, Bruce NC. The explosive-degrading cytochrome P450 system is highly conserved among strains of Rhodococcus spp. Appl Environ Microbiol. 2008 Jul;74(14):4550-2. doi: 10.1128/AEM.00391-08. Epub 2008 May 16. PubMed PMID: 18487400; PubMed Central PMCID: PMC2493155. Hannink NK, Subramanian M, Rosser SJ, Basran A, Murray JA, Shanks JV, Bruce NC. Enhanced transformation of tnt by tobacco plants expressing a bacterial nitroreductase. Int J Phytoremediation. 2007 Sep-Oct;9(5):385-401. doi: 10.1080/15226510701603916. PubMed PMID: 18246725. Travis ER, Bruce NC, Rosser SJ. Short term exposure to elevated trinitrotoluene concentrations induced structural and functional changes in the soil bacterial community. Environ Pollut. 2008 May;153(2):432-9. Epub 2007 Nov 1. PubMed PMID: 17935846. Travis ER, Hannink NK, Van der Gast CJ, Thompson IP, Rosser SJ, Bruce NC. Impact of transgenic tobacco on trinitrotoluene (TNT) contaminated soil community. Environ Sci Technol. 2007 Aug 15;41(16):5854-61. PubMed PMID: 17874797. Travis ER, Bruce NC, Rosser SJ. Microbial and plant ecology of a long-term TNT-contaminated site. Environ Pollut. 2008 May;153(1):119-26. Epub 2007 Sep 6. PubMed PMID: 17825462. Seth-Smith HM, Rosser SJ, Basran A, Travis ER, Dabbs ER, Nicklin S, Bruce NC. Cloning, sequencing, and characterization of the hexahydro-1,3,5-Trinitro-1,3,5-triazine degradation gene cluster from Rhodococcus rhodochrous. Appl Environ Microbiol. 2002 Oct;68(10):4764-71. PubMed PMID: 12324318; PubMed Central PMCID: PMC126434. Larsen NA, Turner JM, Stevens J, Rosser SJ, Basran A, Lerner RA, Bruce NC, Wilson IA. Crystal structure of a bacterial cocaine esterase. Nat Struct Biol. 2002 Jan;9(1):17-21. PubMed PMID: 11742345.