HORSFALL, Louise - University of Edinburgh - School of Biological Sciences

个人简介

2012 Lecturer in Biotechnology, University of Edinburgh 2010 Postdoctoral Research Associate, University of Glasgow 2007 Postdoctoral Research Fellow, University of Leeds 2007 Doctorat en Sciences, Universite de Liege, Belgium 2004 DEA en Sciences, Universite de Liege, Belgium 2002 MChem, University of Oxford

研究领域

Synthetic biology Biotechnology Novel enzymes Protein engineering Directed evolution

近期论文

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Martino C, Kim SY, Horsfall L, Abbaspourrad A, Rosser S, Cooper J and Weitz D. Protein Expression, Aggregation and Triggered Release from Polymersomes, as Artificial Cell-like Structures. Angew. Chem. Int. Ed. Engl. 2012 Jun 25;51(26):6416-6420. Chanasakulniyom M, Martino C, Paterson D, Horsfall L, Rosser S and Cooper J. Expression of Membrane-Associated Proteins within Single Emulsion Cell Facsimiles. Analyst. 2012 Jul 7;137(13):2939-2943. Martino C, Horsfall L, Chen Y, Chanasakulniyom M, Paterson D, Brunet A, Rosser S, Yuan YJ and Cooper JM. Cytoskeletal structural protein expression and its association within the hydrophobic membrane of artificial cell models. ChemBioChem. 2012 Apr 16;13(6);792-795 Horsfall LE, Izougarhane Y, Lassaux P, Selevsek N, Liénard B, Poirel L, Kupper MB, Hoffmann KM, Frère JM, Galleni M and Bebrone C. Broad antibiotic resistance profile of the Subclass B3 Metallo-β-Lactamase GOB-1, a dizinc enzyme. FEBS J. 2011 Apr;278(8):1252-1263 Horsfall LE, Nelson A, Berry A. Identification and characterization of important residues in the catalytic mechanism of CMP-Neu5Ac synthetase from Neisseria meningitidis. FEBS J. 2010 Jul;277(13):2779-2790 Lassaux P, Hamel M, Gulea M, Delbrück H, Mercuri P, Horsfall L, Dehareng D, Kupper M, Frère JM, Hoffmann K, Galleni M, Bebrone C. Mercapto-phosphonate compounds as broad-spectrum inhibitors of the metallo-β-lactamases. J. Med. Chem. 2010 Jul 8;53(13):4862-4876 Liénard BM, Garau G, Horsfall L, Karsisiotis AI, Damblon C, Lassaux P, Papamicael C, Roberts GC, Galleni M, Dideberg O, Frère JM, Schofield CJ. Structural basis for the broad-spectrum inhibition of metallo-β-lactamases by thiols. Org. Biomol. Chem. 2008 Jul 7;6(13):2282-2294 Horsfall LE, Garau G, Liénard BMR, Bebrone C, Dideberg O, Schofield CJ, Frère JM, Galleni M. Competitive inhibitors of the CphA metallo-β-lactamase from Aeromonas hydrophila. Antimicrob. Agents and Chemother. 2007 Jun;51(6):2136-2142. Liénard BM, Horsfall LE, Galleni M, Frère JM and Schofield CJ. Inhibitors of the FEZ-1 metallo-β-lactamase. Bioorg. Med. Chem. Lett. 2007 Feb 15;17(4):964-968 McNeill LA, Hewitson KS, Claridge TD, Seibel JF, Horsfall LE, Schofield CJ. Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803. Biochem J. 2002 Nov 1;367(Pt 3):571-575 McNeill LA, Hewitson KS, Gleadle JM, Horsfall LE, Oldham NJ, Maxwell PH, Pugh CW, Ratcliffe PJ, Schofield CJ. The use of dioxygen by HIF prolyl hydroxylase (PHD1). Bioorg Med Chem Lett. 2002 Jun 17;12(12):1547-1550