GRANNEMAN, Sander - University of Edinburgh - School of Biological Sciences

个人简介

2003 PhD, University of Nijmegen,The Netherlands 2003 - 2006 Post-doctoral fellow at the Department of Molecular Biophysics and Biochemistry, Yale University, New Haven 2006 - 2011 Post-doctoral fellow at the Wellcome Trust Centre for Cell Biology, Edinburgh, UK 2011 - Present Wellcome Trust Research Career Development Fellow and PI at the Centre for Systems and Synthetic Biology (SynthSys), Institute for Structural and Molecular Biology Edinburgh University, UK

研究领域

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My lab is interested in the role of RNA structure and RNA binding proteins in the regulation of gene expression. Most of our research has focussed on the assembly of large macromolecular complexes, such as the yeast ribosome. However, more recently, we have also been working on understanding the role of RNA surveillance factors in the regulation of mRNA transcription and translation in both yeast and bacteria. The goal of our research is to obtain detailed insights into the strategies that organisms use for regulating ribonucleoprotein assembly and mRNA synthesis. For our research we use state-of-the-art methodologies such as CRAC/CLIP, a method to identify RNA substrates for RNA binding proteins in vivo. In addition, my lab has developed a technique dubbed ChemModSeq, a high-throughput structure probing method that makes it possible to quantitatively measure RNA flexibility transcriptome-wide. Using these approaches, we obtained new mechanistic insights into the role of RNA binding proteins into the assembly of the 40S and 60S subunits in yeast.