GORYACHEV, Andrew - University of Edinburgh - School of Biological Sciences

个人简介

1999 Ph.D., University of Toronto 1999 - 2001 NSERC Postdoctoral Fellow, Bunting and Best Department of Medical Research, University of Toronto 2001 -2003 Senior Scientist, Genedata AG, Basel, Switzerland 2003 - 2006 Research Scientist and Team Leader, Bioinformatics Institute, Singapore 2006 - 2011 RCUK Academic Fellow, School of Biological Sciences, University of Edinburgh 2010 - 2011 Lecturer in Computational Cell Biology, School of Biological Sciences, University of Edinburgh 2011 - 2016 Reader in Computational Cell Biology, School of Biological Sciences, University of Edinburgh 2016 - Professor of Computational Cell Biology, School of Biological Sciences, University of Edinburgh

研究领域

My group studies biophysical principles of cellular morphogenesis and intracellular pattern formation. Specifically, we are interested in understanding the mechanisms of symmetry breaking in space and time. In particular, we study cellular developmental programs controlled by small Rho GTPases: Cdc42, Rho and Rac. These include many vital cellular processes, such as the establishment of cell polarity and formation of the cytokinetic furrow.

近期论文

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W. Bement, M. Leda, A. Moe, A. Kita, M. Larson, A. Golding, C. Pfeuti, K-C. Su, A. Miller, A. Goryachev, G. von Dassow, The cell cortex is an excitable medium, Nature Cell Biol., 17(11), 1471 – 1483 (2015). C. Reyes, M. Jin, E. Breznau, R. Espino, R. Delgado-Gonzalo, A. Goryachev, A. Miller, Anillin regulates cell-cell junction integrity by organizing junctional accumulation of Rho-GTP and actomyosin, Curr. Biol. 24(11), 1263 – 1270 (2014). S. Okada, M. Leda, J. Hanna, N. Savage, E. Bi, A. Goryachev, Daughter cell identity emerges from the interplay of Cdc42, septins and exocytosis. Dev. Cell, 26(2) 148 – 161 (2013). A. Goryachev, A. Lichius, G. Wright, N. Read, Excitable behavior can explain the “ping-pong” mode of communication between cells using the same chemoattractant. BioEssays, 34(4), 259 - 266 (2012). N. Zuleger, D. A. Kelly, A. C. Richardson, A. W. Kerr, M. W. Goldberg, A. Goryachev, E. C. Schirmer, A systems analysis reveals different phases of nuclear envelope transmembrane protein mobility. J. Cell Biol., 193(1), 109 - 123 (2011). C. Bicho, D. A. Kelly, H. A. Snaith, A. Goryachev, K. E. Sawin, A catalytic role for Mod5 in the formation of the Tea1 cell polarity landmark. Curr. Biol. 20(19), 1752 - 1757 (2010). A. S. Howell, N. S. Savage, S. A. Johnson, I. Bose, A. W. Wagner, T. R. Zyla, H. F. Nijhout, M. C. Reed, A. Goryachev, and D. J. Lew, Singularity in polarization: re-wiring yeast cells to make two buds, Cell 139(4), 731 – 743 (2009). A. Goryachev, A. Pokhilko, Dynamics of Cdc42 network embodies a Turing-type mechanism of yeast cell polarity. FEBS Letters, 582(10), 1437 - 1443 (2008). A. Goryachev, A. Pokhilko, Computational model explains high activity and rapid cycling of Rho GTPases within protein complexes. PLoS Comput. Biol., 2(12), 1511 - 1521: e172 (2006).