EARNSHAW, Bill - University of Edinburgh - School of Biological Sciences

个人简介

Bill is an elected Fellow of the Academy of Medical Sciences, the Royal Society of Edinburgh and the AAAS and a member of EMBO. He was awarded the Gregor Mendel Medal of the Czech Academy of Sciences in 2002 and an honorary Doctorate of Medicine by Charles University, Prague in 2009.

近期论文

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Carmena M, Wheelock M, Funabiki H, Earnshaw WC. The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis.Nat Rev Mol Cell Biol. 2012 Dec;13(12):789-803. doi: 10.1038/nrm3474. Review. PMID: 23175282; FREE ARTICLE Samejima K, Samejima I, Vagnarelli P, Ogawa H, Vargiu G, Kelly DA, de Lima Alves F, Kerr A, Green LC, Hudson DF, Ohta S, Cooke CA, Farr CJ, Rappsilber J, Earnshaw WC. Mitotic chromosomes are compacted laterally by KIF4 and condensin and axially by topoisimerase IIa.J Cell Biol. 2012 Nov 26;199(5):755-70. doi: 10.1083/jcb.201202155. PMID: 23166350; FREE ARTICLE Kouprina N, Earnshaw WC, Masumoto H, Larionov V. A new generation of human artificial chromosomes for functional genomics and gene therapy. Cell Mol Life Sci. 2013 Apr;70(7):1135-48. doi: 10.1007/s00018-012-1113-3. Epub 2012 Aug 21. Review. PMID: 22907415; FREE ARTICLE Bergmann JH, Martins NM, Larionov V, Masumoto H, Earnshaw WC. HACking the centromere chromatin code: insights from human artificial chromosomes. Chromosome Res. 2012 Jul; 20(5):505-19. doi: 10.1007/s10577-012-9293-0. Review. PMID: 22825423. Ohzeki JI, Bergmann JH, Kouprina N, Noskov VN, Nakano M, Kimura H, Earnshaw WC, Larionov V, Masumoto H. Breaking the HAC Barrier: Histone H3K9 acetyl/methyl balance regulates CENP-A assembly. EMBO J. 2012 May 16;31(10):2391-402. doi: 10.1038/emboj.2012.82. Epub 2012 Apr 3.PubMed PMID: 22473132; FREE ARTICLE Vagnarelli P, Earnshaw WC. Repo-Man-PP1: a link between chromatin remodelling and nuclear envelope reassembly. Nucleus. 2012 Mar 1;3(2):138-42. doi: 10.4161/nucl.19267. Epub 2012 Mar 1. Review. PMID: 22555598; FREE ARTICLE Green LC, Kalitsis P, Chang TM, Cipetic M, Kim JH, Marshall O, Turnbull L, Whitchurch CB, Vagnarelli P, Samejima K, Earnshaw WC, Choo KH, Hudson DF. Contrasting roles of condensin I and II in mitotic chromosome formation. J Cell Sci. 2012 Mar 15;125(Pt 6):1591-1604. Epub 2012 Feb 17. PubMed PMID: 22344259. Bergmann JH, Jakubsche JN, Martins NM, Kagansky A, Nakano M, Kimura H, Kelly DA, Turner BM, Masumoto H, Larionov V, Earnshaw WC. Epigenetic engineering: histone H3K9 acetylation is compatible with kinetochore structure and function. J Cell Sci. 2012 Jan 15;125(Pt 2):411-21. Epub 2012 Feb 13. PubMed PMID: 22331359. Carmena M, Pinson X, Platani M, Salloum Z, Xu Z, Clark A, Macisaac F, Ogawa H, Eggert U, Glover DM, Archambault V, Earnshaw WC. The chromosomal passenger complex activates Polo kinase at centromeres. PLoS Biol. 2012 Jan;10(1):e1001250. Epub 2012 Jan 24. PubMed PMID: 22291575; FREE ARTICLE Kim JH, Kononenko A, Erliandri I, Kim TA, Nakano M, Iida Y, Barrett JC, Oshimura M, Masumoto H, Earnshaw WC, Larionov V, Kouprina N. Human artificial chromosome (HAC) vector with a conditional centromere for correction of genetic deficiencies in human cells. Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20048-53. Epub 2011 Nov 28. PubMed PMID: 22123967; FREE ARTICLE Flors C, Earnshaw WC. Super-resolution fluorescence microscopy as a tool to study the nanoscale organization of chromosomes. Curr Opin Chem Biol. 2011 Dec;15(6):838-44. Epub 2011 Nov 16. Review. PubMed PMID: 22098720. Vagnarelli P, Ribeiro S, Sennels L, Sanchez-Pulido L, de Lima Alves F, Verheyen T, Kelly DA, Ponting CP, Rappsilber J, Earnshaw WC. Repo-Man coordinates chromosomal reorganization with nuclear envelope reassembly during mitotic exit. Dev Cell. 2011 Aug 16;21(2):328-42. Epub 2011 Aug 4. PubMed PMID: 21820363. Ohta S, Bukowski-Wills JC, Wood L, de Lima Alves F, Chen Z, Rappsilber J, Earnshaw WC. Proteomics of isolated mitotic chromosomes identifies the kinetochore protein Ska3/Rama1. Cold Spring Harb Symp Quant Biol. 2010;75:433-8. Epub 2011 Feb 2. PubMed PMID: 21289047. Bergmann JH, Rodriguez MG, Martins NM, Kimura H, Kelly DA, Masumoto H, Larionov V, Jansen LE, Earnshaw WC. Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochore. EMBO J. 2011 Jan 19;30(2):328-40. Epub 2010 Dec 14. PubMed PMID: 21157429; FREE ARTICLE Fant X, Samejima K, Carvalho A, Ogawa H, Xu Z, Yue Z, Earnshaw WC, Ruchaud S. Use of DT40 conditional-knockout cell lines to study chromosomal passenger protein function. Biochem Soc Trans. 2010 Dec;38(6):1655-9. PubMed PMID: 21118143. Ohta S, Wood L, Bukowski-Wills JC, Rappsilber J, Earnshaw WC. Building mitotic chromosomes. Curr Opin Cell Biol. 2011 Feb;23(1):114-21. Epub 2010 Oct 23. Review. PubMed PMID: 20974528; FREE ARTICLE Xu Z, Vagnarelli P, Ogawa H, Samejima K, Earnshaw WC. Gradient of increasing Aurora B kinase activity is required for cells to execute mitosis. J Biol Chem. 2010 Dec 17;285(51):40163-70. Epub 2010 Oct 18. PubMed PMID: 20956539; FREE ARTICLE Ohta S, Bukowski-Wills JC, Sanchez-Pulido L, Alves Fde L, Wood L, Chen ZA, Platani M, Fischer L, Hudson DF, Ponting CP, Fukagawa T, Earnshaw WC, Rappsilber J. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. Cell. 2010 Sep 3;142(5):810-21. PubMed PMID: 20813266; FREE ARTICLE Iida Y, Kim JH, Kazuki Y, Hoshiya H, Takiguchi M, Hayashi M, Erliandri I, LeeHS, Samoshkin A, Masumoto H, Earnshaw WC, Kouprina N, Larionov V, Oshimura M. Human artificial chromosome with a conditional centromere for gene delivery and gene expression. DNA Res. 2010 Oct;17(5):293-301. Epub 2010 Aug 26. PubMed PMID: 20798231; FREE ARTICLE Fernandez-Miranda G, Perez de Castro I, Carmena M, Aguirre-Portoles C, Ruchaud S, Fant X, Montoya G, Earnshaw WC, Malumbres M. SUMOylation modulates the function of Aurora-B kinase. J Cell Sci. 2010 Aug 15;123(Pt 16):2823-33. Epub 2010 Jul 27. PubMed PMID: 20663916; FREE ARTICLE Ribeiro SA, Vagnarelli P, Dong Y, Hori T, McEwen BF, Fukagawa T, Flors C, Earnshaw WC. A super-resolution map of the vertebrate kinetochore. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10484-9. Epub 2010 May 18. PubMed PMID: 20483991; FREE ARTICLE Patzlaff JS, Terrenoire E, Turner BM, Earnshaw WC, Paulson JR. Acetylation of core histones in response to HDAC inhibitors is diminished in mitotic HeLa cells. Exp Cell Res. 2010 Aug 1;316(13):2123-35. Epub 2010 May 7. PubMed PMID: 20452346; FREE ARTICLE Xu Z, Ogawa H, Vagnarelli P, Bergmann JH, Hudson DF, Ruchaud S, Fukagawa T, Earnshaw WC, Samejima K. INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization. J Cell Biol. 2009 Nov 30;187(5):637-53. Erratum in: J Cell Biol. 2010 Feb 22;188(4):611. PubMed PMID: 19951914; FREE ARTICLE Carmena M, Ruchaud S, Earnshaw WC. Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins. Curr Opin Cell Biol. 2009 Dec;21(6):796-805. Review. PubMed PMID: 19836940; FREE ARTICLE Cardinale S, Bergmann JH, Kelly D, Nakano M, Valdivia MM, Kimura H, Masumoto H, Larionov V, Earnshaw WC. Hierarchical inactivation of a synthetic human kinetochore by a chromatin modifier. Mol Biol Cell. 2009 Oct;20(19):4194-204. Epub 2009 Aug 5. PubMed PMID: 19656847; FREE ARTICLE