CHAMBERS, Ian - University of Edinburgh - School of Biological Sciences

个人简介

1983 - BSc (Honours, 1st Class): Biochemistry, Strathclyde, Glasgow 1987 - PhD: Beatson Institute for Cancer Research, Glasgow 1987 - 1991: Postdoc with Nobel Laureate Paul Berg, Stanford, USA 1991 - 2006: Senior Postdoc with Austin Smith, Edinburgh 2007 - 2010: Reader, Edinburgh 2010 - present: Professor of Pluripotent Stem Cell Biology, Edinburgh

近期论文

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The pluripotency factor Nanog regulates pericentromeric heterochromatin organization in mouse embryonic stem cells.Novo, Clara Lopes, Tang Calvin, Ahmed Kashif, Djuric Ugljesa, Fussner Eden, Mullin Nicholas P., Morgan Natasha P., Hayre Jasvinder, Sienerth Arnold R., Elderkin Sarah, et al. , Genes Dev, 2016 May 1, Volume 30, Issue 9, p.1101-15, (2016) Distinct Signaling Requirements for the Establishment of ESC Pluripotency in Late-Stage EpiSCs.Illich, Damir Jacob, Zhang Miao, Ursu Andrei, Osorno Rodrigo, Kim Kee-Pyo, Yoon Juyong, Araúzo-Bravo Marcos J., Wu Guangming, Esch Daniel, Sabour Davood, et al. , Cell Reports, 2016 Apr 14, Issue 15, p.1-14, (2016) Reprogramming Roadblocks Are System Dependent.Chantzoura, Eleni, Skylaki Stavroula, Menendez Sergio, Kim Shin-Il, Johnsson Anna, Linnarsson Sten, Woltjen Knut, Chambers Ian, and Kaji Keisuke , Stem Cell Reports, 2015 Sep 8, Volume 5, Issue 3, p.350-64, (2015) Selective influence of Sox2 on POU transcription factor binding in embryonic and neural stem cells.Mistri, Tapan Kumar, Devasia Arun George, Chu Lee Thean, Ng Wei Ping, Halbritter Florian, Colby Douglas, Martynoga Ben, Tomlinson Simon R., Chambers Ian, Robson Paul, et al. , EMBO Rep, 2015 Aug 11, (2015) Lessons in learning: An effective process for engaging 12- to 14-year-olds in stem cell biology.Kemp, Emma, and Chambers Ian , EMBO Rep, 2015 Jan, Volume 16, Issue 1, p.7-13, (2015) Transcription factor heterogeneity in pluripotent stem cells: a stochastic advantage.Torres-Padilla, Maria-Elena, and Chambers Ian , Development, 2014 Jun, Volume 141, Issue 11, p.2173-81, (2014) A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.Gagliardi, Alessia, Mullin Nicholas P., Tan Zi Ying, Colby Douglas, Kousa Anastasia I., Halbritter Florian, Weiss Jason T., Felker Anastasia, Bezstarosti Karel, Favaro Rebecca, et al. , EMBO J, 2013 Aug 14, Volume 32, Issue 16, p.2231-47, (2013) The role of pluripotency gene regulatory network components in mediating transitions between pluripotent cell states.Festuccia, Nicola, Osorno Rodrigo, Wilson Valerie, and Chambers Ian , Curr Opin Genet Dev, 2013 Oct, Volume 23, Issue 5, p.504-11, (2013) Hes1 desynchronizes differentiation of pluripotent cells by modulating STAT3 activity.Zhou, Xinzhi, Smith Andrew J. H., Waterhouse Anna, Blin Guillaume, Malaguti Mattias, Lin Chia-Yi, Osorno Rodrigo, Chambers Ian, and Lowell Sally , Stem Cells, 2013 Aug, Volume 31, Issue 8, p.1511-22, (2013) Reduced Oct4 expression directs a robust pluripotent state with distinct signaling activity and increased enhancer occupancy by Oct4 and Nanog.Karwacki-Neisius, Violetta, G?ke Jonathan, Osorno Rodrigo, Halbritter Florian, Ng Jia Hui, Wei?e Andrea Y., Wong Frederick, Gagliardi Alessia, Mullin Nicholas P., Festuccia Nicola, et al. , Cell Stem Cell, 2013 May 2, Volume 12, Issue 5, p.531-45, (2013) The pluripotent genome in three dimensions is shaped around pluripotency factors.de Wit, Elzo, Bouwman Britta A. M., Zhu Yun, Klous Petra, Splinter Erik, Verstegen Marjon J. A. M., Krijger Peter H. L., Festuccia Nicola, Nora Elphège P., Welling Maaike, et al. , Nature, 2013 Sep 12, Volume 501, Issue 7466, p.227-31, (2013)