ARNOT, David - University of Edinburgh - School of Biological Sciences

个人简介

1981 Ph.D., MRC Biochemical Parasitology Unit, Cambridge. 1980-1983 Postdoctoral Fellow, Department of Biochemistry and Molecular Biology, Harvard University. 1983-1989 Assistant Professor, Department of Medical and Molecular Parasitology, New York University. 1989 Joined University of Edinburgh

研究领域

My research interests are in the area of infection and immunity to human malaria, particularly where this field interacts with the genetics and molecular biology of the major human malaria parasite species, Plasmodium falciparum. My research work is strongly oriented towards the study of human malaria infection in Africa. Long established field research in Sudan has involved analysis of the micro-epidemiology of disease transmission and on trying to understand normal human immune responses to genetically characterised natural malaria infections, studies carried out in close collaboration with other groups in Edinburgh University and researchers at the University of Copenhagen and the University of Khartoum. New, European Union funded research initiatives are extending these studies to different malaria epidemiological situations in West Africa, in collaboration with the Noguchi Institute for Medical Research at the University of Ghana. More molecular biological research in the laboratory involves studies of signal transduction during the cell cycle of the malaria parasite and collaboration with the Malaria Genome Project for establishing the complete genomic sequence of the malaria parasite. My teaching interests are in parasitology and infectious disease research, parasite molecular biology and vaccinology. I am also interested in the history of genetics and tropical medicine and African and Islamic studies.

近期论文

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Sowa K.M.P, Cavanagh, D.R, Creasey, A.M., Raats, J., McBride J.S., Sauerwein, R. Roeffen, W.F., & Arnot, D.E. (2001). Isolation of a monoclonal antibody from a malaria patient-derived phage display library recognising the Block 2 epitope of Plasmodium falciparum merozoite surface protein-1. Molecular & Biochemical Parasitology, 112, 143-149. Binks, R.H., Baum, J., Oduola, A.M.J., Arnot, D.E., Babiker, H.A., Kremsner, P., Roper, C., Greenwood, B.M. & Conway, D.J. (2001). Population genetic analysis of the Plasmodium falciparum erythrocyte binding antigen-175 (eba-175) gene. Molecular & Biochemical Parasitology, 114 , 63-71. Ofusu-Okyere, A., Mackinnon, M., Sowa, M.P.K., Koram, K.A., Nkrumah, F., Osei, Y.D., Hill, W.G., Wilson, M.D. & Arnot, D.E. (2001). A positive relationship between clinical malaria episodes and increased number of Plasmodium falciparum clones in Ghanaian children during the transition into the malaria transmission season. Parasitology, 123, 113-123. Arnot, D.E. (2001). Training mothers to give anti-malarial drugs reduces deaths in Ethiopia. Evidence-Based Healthcare, 5, 165-6 Arnot, D.E. (2002). The influence of genetic complexity in Plasmodium falciparum infections on the epidemiology of malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene. 96, S 1, 131-136 Salanti, A., Jensen, A.T. R., Zornig, H.D., Staalso, T., Jorgensen, L., Neilsen, M.A., Khattab, A., Arnot, D.E., Klinkert, M.Q., Hviid, L. & Theander, T.G. (2002). A sub-family of common and highly conserved Plasmodium falciparum var genes. Molecular & Biochemical Parasitology, 122, 111-116 Hamad, A.A., Nuguud, A., Arnot, D.E., Abdel-Muhsin, A., Giha, H.A., Satti, G.M.H., Theander, T.G., Creasey, A.M., Babiker, H.A., & El Niem, D. (2002). A marked seasonality of malaria transmission in two rural sites in Eastern Sudan. Acta Tropica. 83. 71-82. Staalsoe, T., Hamad, A.A., Hviid, L., El Hassan, I.M., Arnot, D.E. & Theander, T.G. (2002). In vivo switching between variant surface antigen genes in human Plasmodium falciparum infection. Journal of Infectious Diseases, 186:719-722. Salanti, A., Staalsoe, T., Lavstsen, T., Jensen, A.T.R., Sowa, M.P. K. Arnot, D.E., Hviid, L. & Theander, T.G. (2003). Selective up-regulation of a single distinctly structures var gene in chondroitin sulphate A- adhering Plasmodium falciparum involved in pregnancy-associated malaria. Molecular Microbiology, 49, 179-191. Creasey, A.R., Staalsoe, T., Raza, A., Arnot, D.E., & Rowe, A. (2003). Non-specific IgM and Chondroitin Sulphate A binding are linked phenotypes of Plasmodium falciparum isolates implicated in malaria during pregnancy. Infection & Immunity, 71, 4767-4771. Lavstsen, T., Salanti, A., Jensen, A.T.R., Arnot, D.E., & Theander, T.G. (2003). Sub grouping of Plasmodium falciparum 3D7 var genes based on sequence analysis of coding and non-coding regions. Malaria Journal, 2, 27. (URL http://www.malariajournal.com/content/2/1/27) Kordai Sowa, M.P., Sharling, L., Humphreys, G., Cavanagh, D.R., Gregory, W.B., Fenn, K., Wiltshire, A., Creasey A.R. & Arnot, D.E. (2004). High throughput immuno-screening of cDNA expression libraries produced by in vitro recombination; exploring the Plasmodium falciparum proteome. Molecular & Biochemical Parasitology,133, 267-274, Creasey, A.M. Giha, H.,Hamad, A.A., El Hassan,I.M., Theander, T.G & Arnot, D.E. (2004). 11 years of malaria surveillance in a Sudanese village highlights unexpected variation in individual disease susceptibility and outbreak severity. Parasitology, 129, 263-271. Sharling, L., Envold, A., Sowa, K.M.P., Staalsoe, T., & Arnot, D.E. (2004). Antibodies from malaria?exposed pregnant women recognise trypsin resistant epitopes on the surface of Plasmodium falciparum infected erythrocytes selected for adhesion to chondroitin sulphate A. Malaria Journal, 2, 27( URL http:/www.malariajournal.com/content/3/1/31) 1-8. Further definition of PfEMP-1 DBL-1alpha domains mediating resetting adhesion of Plasmodium falciparum. Russell, C., Mercereau-Puijalon,O., Le Scanf, C., Steward, M., & Arnot, D.E. (2005). Molecular & Biochemical Parasitology, 144, 109-113. Generation of cross-protective antibodies against Plasmodium falciparum sequestration by immunization with an erythrocyte membrane protein-1 Duffy binding-like alpha domain. Moll, K., Pettersen, F., Vogt, A.M., Jonsson, C., Rasti, N., Ahuja, S., Spangberg, M., Mercereau-Puijalon, O., Arnot, D.E., Wahlgren, M. & Chen, Q. (2007). Infection and Immunity, 75, 211-9. Rapid and specific biotin labelling of the erythrocyte surface antigens of both cultured and ex-vivo Plasmodium parasites. Sharling, L., Sowa, K.M., Thompson, J., Kyriacou, H.M. & Arnot, D.E. Malaria Journal 2007, 6:66 22nd May 2007. The dog that did not bark: malaria vaccines without antibodies. Heppner, D.G., Schwenk, R.J., Arnot, D., Sauerwein, R.W. & Luty, A.J.F. (2007). Trends in Parasitology, 23, 293-296. Changes in var gene mRNA levels during erythrocyte development in two phenotypically distinct Plasmodium falciparum parasites. Dahlback, M., Lavstsen, T., Salanti, A., Hviid, L., Arnot, D.E., Theander, T. and Nielsen, M. Malaria Journal 2007, 6, 78 (12th June 2007). Comparative testing of the antigenicity, immunogenicity and in vitro culture growth inhibition capacity of near-production variants of Plasmodium falciparum merozoite proteins in malaria vaccine development. Arnot, D.E., Cavanagh, D., Creasy, A.M., Kordai Sowa, M.P., Remarque, E., Holder, A.M., Longacre, S., & Thomas, A. (2007). Infection and Immunity, in press.