个人简介

A.B., Barnard College, 1974; Ph.D., Columbia University, 1978; D.Sc.h.c., New Jersey Institute; Kenyon College; Yale University; Hamilton College; Williams College; Lawrence University; Columbia University; D.L.h.c., Skidmore College. Visiting Associate, Caltech, 1989; Professor, 1989-; Hanisch Professor, 1997-. Chair, 2009-.

研究领域

In the Barton group, we examine the chemical and physical properties of DNA and the biological implications of those properties. Our research has shown that DNA is more than just the library of the cell, existing only to hold genetic information; on the contrary, DNA is a molecule rich in complexity and full of surprises. Previously, the Barton group has shown that the overlapping π system of stacked DNA bases can mediate the transfer of electrical charge (electrons and holes) over long distances. This DNA-mediated charge transfer (DNA CT) occurs in a variety of sequence contexts and between various types of charge donors and acceptors, shows a shallow distance dependence, and is exquisitely sensitive to perturbations to the base stack such as chemical damage and base pair mismatches. Our current research is focused in three areas: Using the unique binding environment of DNA to develop specific probes for DNA mismatches and lesions Examining the biological implications of DNA CT Designing electrochemical devices which can be used to sense DNA damage or report on DNA and protein binding events.

Biochemistry and Molecular Biophysics; Chemistry

近期论文

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"DNA Charge Transport within the Cell" M. A. Grodick, N. B. Muren, and J. K. Barton Biochemistry 54 962-973(2015). "Oxidation of p53 through DNA Charge Transport Involves a Network of Disulfides within the DNA-Binding Domain" K. N. Schaefer, W. M. Geil, M. J. Sweredoski, A. Moradian, S. Hess, and J. K. Barton Biochemistry 54 932-941(2015). "Electrocatalysis in DNA Sensors" A. L. Furst, M. G. Hill and J. K. Barton Polyhedron 84 150-159(2014). "Targeted Chemotherapy with Metal Complexes" A. G. Weidmann, A. C. Komor and J. K. Barton Comments on Inorganic Chemistry 34 114-123(2014). "An Unusual Ligand Coordination Gives Rise to a New Family of Rhodium Metalloinsertors with Improved Selectivity and Potency" A. C. Komor and J. K. Barton J. Am. Chem. Soc. 136 14160-14712(2014). "Label-free electrochemical detection of human methyltransferase from tumors" A. L. Furst, N. B. Muren, M. G. Hill and J. K. Barton Proc. Natl. Acad. Sci. USA 111 14985-14989(2014). "Construction and Application of a RhÐPt DNA Metalloinsertor Conjugate" A. G. Weidmann and J. K. Barton Inorg. Chem. 53 7812-7814(2014). "DNA-Mediated Oxidation of p53" K. N. Schaefer and J. K. Barton Biochemistry 53 3467-3475(2014). "DNA-Mediated Signaling by Proteins with 4Fe-4S Clusters Is Necessary for Genomic Integrity" M. A. Grodick, H. M. Segal, T. J. Zwang and J. K. Barton J. Am. Chem. Soc. 136 6470-6478(2014). "DNA-Modified Electrodes Fabricated Using Copper-Free Click Chemistry for Enhanced Protein Detection" A. L. Furst, M. G. Hill and J. K. Barton Langmuir 29 16141(2013). "Electrochemical Patterning and Detection of DNA Arrays on a Two-Electrode Platform" A. L. Furst, S. Landfield, M. G. Hill and J. K. Barton J. Am. Chem. Soc. 135 19099(2013). "An Inducible, Isogenic Cancer Cell Line System for Targeting the State of Mismatch Repair Deficiency" J. M. Bailis, M. L. Gordon, J. L. Gurgel, A. C. Komor, J. K. Barton and I. R. Kirsch PLOS ONE 8 e78726(2013) "Luminescence of [Ru(bpy)2(dppz)]2+ Bound to RNA Mismatches" A. J. McConnell, H. G. Song and J. K. Barton Inorg. Chem. 52 10131(2013). "DNA Protection by the Bacterial Ferritin Dps via DNA Charge Transport" A. R. Arnold and J. K. Barton J. Am. Chem. Soc. 135 15726(2013). "Electrochemical Assay for the Signal-On Detection of Human DNA Methyltransferase Activity" N. B. Muren and J. K. Barton J. Am. Chem. Soc. 135 16632(2013). "Intraduplex DNA-Mediated Electrochemistry of Covalently Tethered Redox-Active Reporters" C. G. Pheeney and J. K. Barton J. Am. Chem. Soc. 135 14944(2013). "Multiplexed Electrochemistry of DNA-Bound Metalloproteins" C. G. Pheeney, A. R. Arnold, M. A. Grodick and J. K. Barton J. Am. Chem. Soc. 135 11869(2013). "Biological effects of simple changes in functionality on rhodium metalloinsertors" A. G. Weidmann, A. C. Komor and J. K. Barton Philosophical Transactions of the Royal Society A 371 20120177(2013). "The path for metal complexes to a DNA target" A. C. Komor and J. K. Barton Chem. Commun. 49 3617-3630(2013). "Luminescent Properties of Ruthenium(II) Complexes with Sterically Expansive Ligands Bound to DNA Defects" A. J. McConnell , M. H. Lim , E. D. Olmon , H. Song , E. E. Dervan , and J. K. Barton Inorg. Chem. 51 12511-12520(2012).