Zare, Richard N. - Stanford University - Department of Chemistry

个人简介

1961 B.A. (Chemistry and Physics), Harvard University 1961-1963 Postgraduate work, University of California at Berkeley 1964 Ph.D. (Chemical Physics), Harvard University, (NSF Predoctoral Fellow) 1964-1965 Postdoctoral Research Associate, Joint Institute for Laboratory Astrophysics (JILA), University of Colorado 1965-1966 Assistant Professor, Department of Chemistry, Massachusetts Institute of Technology 1966-1968 Assistant Professor, Department of Physics and Astrophysics, University of Colorado 1968-1969 Associate Professor, Department of Physics and Astrophysics and Department of Chemistry, University of Colorado 1969-1977 Professor, Department of Chemistry, Columbia University 1975-1977 Higgins Professor of Natural Science, Columbia University 1977- Professor, Department of Chemistry, Stanford University 1980-1985 Shell Distinguished Professor of Chemistry, Stanford University 1982 Christensen Fellow, St. Catherine's College, Oxford University 1984-1986 Stanford University Fellow 1985- Fellow Adjoint, Joint Institute for Laboratory Astrophysics, University of Colorado 1987- Marguerite Blake Wilbur Professor in Natural Science, Stanford University 1992- Professor of Physics, Stanford University 2006-2010 Howard Hughes Medical Institute Professor, Stanford University

研究领域

Quantum control of molecular collisions near 1 kelvin Photon catalysis of gas- and condensed-phase reactions Abiotic production of sugar phosphates and ribonucleosides in aqueous microdroplets Microdroplet chemistry for the synthesis of gold nanostructures Microdroplet reactions Mechanistic study of reaction acceleration and heterogeneous catalytic oil upgrading in microdroplets Non-invasive diagnosis by mass spectrometry and machine learning Artificial intelligence enabled innovations and discoveries in chemistry Investigations in human sweat & breath for new biomarker discovery Electrically controlled drug release from drug-loaded polymer nanocomposite films Surgical margin evaluation of clear cell renal cell carcinoma (ccRCC) using desorption electrospray ionization mass spectrometry imaging (DESI-MSI) Biochemical reactions in microdroplets from a theta tip capillary Mass spectrometry imaging for biomedical applications Design of nanoparticles for biomedical applications In situ measurement of ligand-receptor interactions at the cell surface by ambient ionization mass spectrometry Monitoring of neurochemical release from PC-12 cells using ambient ionization mass spectrometry Discovery of potent inhibitors against GPAT (glycerol-3-phosphate acyltransferase) for treatment of cancer and other diseases In-situ ambient ionization mass spectrometry for mechanistic studies of organometallic catalysis Biosensors for Detection of Pathogenic Microorganisms Composite silane-based polymers as substrate material and electrospray emitter for ambient ionization mass spectrometry

近期论文

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S. Banerjee, A. C.-Y. Wong, X. Yan, B. Wu, R. J. Tibshirani, J. D. Brooks, and R. N. Zare, "Early Detection of Unilateral Ureteral Obstruction by Desorption Electrospray Ionization Mass Spectrometry," Sci. Rep. 9, 11007 (2019). P. Zhao, R. N. Zare, and H. Chen, "Absolute Quantification of Peptides by Coulometric Mass Spectrometry," J. Am. Soc. Mass Spec. 30, 2398-2407 (2019). J. K. Lee, K. L. Walker, H. S. Han, J. Kang, F. B. Prinz, R. M. Waymouth, H. G. Nam, and R. N. Zare, "Spontaneous Generation of Hydrogen Peroxide from Aqueous Microdroplets," Proc. Nat. Acad. Sci (US) 116, 19294-19298 (2019). C. Liu, J. Li , H. Chen, and R. N. Zare, "Scale-Up of Microdroplet Reactions by Heated Ultrasonic Nebulization," Chem. Sci. 10, 9367 - 9373 (2019). S. Banerjee and R. N. Zare, "Influence of Inlet Capillary Temperature on the Microdroplet Chemistry Studied by Mass Spectrometry," J. Phys. Chem. 123, 7704-7709 (2019). X. Wu, H. Yue, Y. Zhang, X. Gao, X. Li, L. Wang, Y. Cao, M. Hou, H. An, L. Zhang, S. Li, J.-Y. Ma, H. Lin, Y. Fu, H. Gu, W.-Y. Lou, W. Wei, R. N. Zare, and J. Ge, "Packaging and delivering enzymes by amorphous metal-organic frameworks," Nat. Comm. 10, 5165 (2019). D. Gao, F. Jin, J. K. Lee, and R. N. Zare, "Aqueous Microdroplets Containing Only Ketones or Aldehydes Undergo Dakin and Baeyer-Villiger Reactions," Chem. Sci. 10, 10974-10978 (2019). E. Gnanamani, X. Yan, and R. N. Zare, "Chemoselective N-Alkylation of Indoles in Aqueous Microdroplets," Angew. Chemie Int. Ed. 59, 1-5 (2020). Z. Zhou, D. Alvarez, C. Milla, and R. N. Zare, "Identification of Cystic Fibrosis from Specific Signatures in Perspiration Samples: A Proof of Concept," Proc. Nat. Acad. Sci. (USA) 116, 24408-24412 (2019). R. Narayanan, X. Song, H. Chen, and R. N. Zare, "Teflon Spray Ionization Mass Spectrometry," J. Am. Soc. Mass Spec. 31, 234-239 (2020) . K. Margulis, A. Honkala, I. Kalashnikova, S. E. Noll, M. Hill, R. N. Zare, and B. R. Smith, "Nanoparticles Decorated with Granulocyte-Colony Stimulating Factor for Targeting Myeloid Cells," Nanoscale 12, 2752-2763 (2020). K. J. Wert, J. D.Sengillo, G.l Velez, Kanchustambham Vijayalakshmi, V. Shankar, R. N. Zare, A. G. Bassuk, S. H. Tsang, and V. B. Mahajan, "Metabolite Therapy Guided by Liquid Biopsy Proteomics Delays Retinal Neurodegeneration," EBioMedicine 52, 102636 (2020). X. Zhong, H. Chen, and R. N. Zare, "Ultrafast Enzymatic Digestion of Proteins by Microdroplet Mass Spectrometry," Nat. Comm. 11, 1049 (2020). K. Luo, J. Li , Y. Cao, C. Liu , J. Ge , H. Chen , R. N. Zare, "Reaction of Chloroauric Acid with Histidine in Microdroplets Yields a Catalytic Au-(His)2 complex," Chem. Sci. 11, 2558 (2020). V. Kanchustambham, V. Shankar, R. M. Bain, R. Nolley, G. A. Sonn, C.-S. Kao, H. Zhao, R. Tibshirani, R. N. Zare, and J. D. Brooks, "Identiﬁcation of Diagnostic Metabolic Signatures in Clear Cell Renal Cell Carcinoma using Mass Spectrometry Imaging," Int. J. Cancer 147, 256-265 (2020). J. van den Berg, Y.-H. Lai, G. Wadsworth, W. Lamberti, H. Woo, S. Raman, and R. N. Zare. "Spraying model PAHs on charged TiO2 surface for high-efficiency degradation," Energy & Fuels 34, 4289-4295 (2020). M. T. Dulay, J. K. Lee, A. C. Mody, R. Narasimhan, D. M. Monack, and R. N. Zare, "Spraying Small Water Droplets Acts as a Bacteriocide," QRB Discovery (in press, 2020). M. Zhang, Y. Zou, X. Xu, X. Zhang, M. Gao, J. Song, P. Huang, Q. Chen, Z. Zhu, W. Lin, R. N. Zare, and C. Yang, "Highly Parallel and Efficient Single Cell mRNA with Paired Picoliter Chambers," Nat. Comm. 11, 2118 (2020). W. E. Perreault, H. Zhou, N. Mukherjee, and R. N. Zare, "Harnessing the power of adiabatic passage to prepare the highly vibrationally excited H2 (v = 7, j = 0) level," Phys. Rev. Lett. 124, 163202 (2020). X. Song, X. Yang, R. Narayanan, V. Shankar, S. Ethiraj, X. Wang, N. Duan, Y.-H. Ni, Q. Hu, and R. N. Zare, "Oral Squamous Cell Carcinoma Diagnosed from Saliva Metabolic Profiling," Proc. Nat. Acad. Sci. (USA) (in press, 2020).